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Database: UniProt
Entry: G8YFN8_PICSO
LinkDB: G8YFN8_PICSO
Original site: G8YFN8_PICSO 
ID   G8YFN8_PICSO            Unreviewed;      1079 AA.
AC   G8YFN8;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   05-JUN-2019, entry version 40.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   Name=Piso0_002676 {ECO:0000313|EMBL:CCE81987.1};
GN   ORFNames=GNLVRS01_PISO0I15364g {ECO:0000313|EMBL:CCE81987.1};
OS   Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 /
OS   NBRC 10061 / NRRL Y-12695) (Hybrid yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Millerozyma.
OX   NCBI_TaxID=559304 {ECO:0000313|EMBL:CCE81987.1, ECO:0000313|Proteomes:UP000005222};
RN   [1] {ECO:0000313|Proteomes:UP000005222}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL
RC   Y-12695 {ECO:0000313|Proteomes:UP000005222};
RX   DOI=10.1534/g3.111.000745;
RA   Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA   Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA   Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA   Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M.,
RA   Mallet S., Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J.,
RA   Seret M.L., Talla E., Samson G., Jubin C., Poulain J., Vacherie B.,
RA   Barbe V., Pelletier E., Sherman D.J., Westhof E., Weissenbach J.,
RA   Baret P.V., Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT   "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps
RT   of genome resolution following polyploidization.";
RL   G3 (Bethesda) 2:299-311(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
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DR   EMBL; FO082051; CCE81987.1; -; Genomic_DNA.
DR   STRING; 4920.XP_004200106.1; -.
DR   EnsemblFungi; CCE81987; CCE81987; GNLVRS01_PISO0I15364g.
DR   Proteomes; UP000005222; Chromosome I.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005222};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005222};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      118    454       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      518    947       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      985   1057       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     54       Disordered. {ECO:0000256|MobiDB-lite:
FT                                G8YFN8}.
FT   COMPBIAS     16     43       Polar. {ECO:0000256|MobiDB-lite:G8YFN8}.
SQ   SEQUENCE   1079 AA;  123499 MW;  C44128460AEA3137 CRC64;
     MSQTKRAYDT AHQEQAHSLP AASQDMLSSQ VELSSSQKQL LKKIKRPNGT EEPSEFEQEL
     LEMTQASGRI GNEEVQSWKR PPLPADFDAS TTDITFQQLD AEESMIDGLS SARFFGITEE
     GYSVLCEVRN FLHYFYVPVP KGFFRDSHLT QFENYLKNNY QGVCKAEICL KESIWGFNNN
     VKSPFLKIYV DNSKNISKIR GSFERGEIRF ENLFPPQNVT YDNINYLLRL MVDCKISGMS
     WLTLPKGKYG MISDFEKVST CQLECFIDYR DIISHPPDGE WLKLAPLRVL SFDIECSGRK
     GIFPEADQDS VIQIANVVSK TGESKPFVRN VFTVNTCASI IGSQIFEHET EEEMLMHWRD
     FIVDVDPDII IGYNIANFDL PYLIDRAKAL GLSDFPFFGR LPSVKQEVKD TVFSSRAYGT
     RENKVVNIDG RMQLDLLQFI QREYKLRSYT LNSVSAHFLG EQKEDVQHSI ITDLQNGNRE
     TRRRLAVYCL KDAYLPLRLM EKLMCLVNYT EMARVTGVPF SYLLARGQQI KVISQLFRKC
     LEDNIVIPNM KSEGTNEDYE GAIVIEPVRG YYDVPIATLD FSSLYPSIMM AHNLCYTTLL
     NKQTINTLNL KEDDYTLTPN GDYFVKDHKR KGILPTILKE LLTARKKAKA DLKKETDPFK
     KDVLNGRQLA LKISANSVYG FTGATIGKLP CLAISSSVTA FGREMIEKTK NEVQEHYSIK
     NGFPFDSQVI YGDTDSVMVR FGFNDLETCM KYGEEAANYV STKFKDPIKL EFEKVYFPYL
     LINKKRYAGL YWTNPQKFDK MDTKGIETVR RDNCRLVQNV ITKVLEYILE ERDVAKAEHY
     VKQTIADLLQ NRIDLSQLVI TKAYSKHDYA AKQAHIELAE RMKKRDPGSA PTLGDRVAYV
     IINSASSKNY EKSEDPLYVL EHSLPIDVKY YLDNQLSNPL MRIFEPILGE KKAKELLAGS
     HTRTIKMSAP KTGGLMKFAK KAELCKNCKS PLKPTNKGAL CENCLPMAPK LYGDALAQMN
     YLENKFSRLW TECQRCQGSL HQEVLCSNKD CPIFYMRKKA QKDVAAQAKD LHKWNETLW
//
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