ID G8YH32_PICSO Unreviewed; 398 AA.
AC G8YH32;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Piso0_003062 protein {ECO:0000313|EMBL:CCE80734.1};
GN Name=Piso0_003062 {ECO:0000313|EMBL:CCE80734.1};
GN ORFNames=GNLVRS01_PISO0G04054g {ECO:0000313|EMBL:CCE79969.1},
GN GNLVRS01_PISO0H04055g {ECO:0000313|EMBL:CCE80734.1};
OS Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC
OS 10061 / NRRL Y-12695) (Hybrid yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Millerozyma.
OX NCBI_TaxID=559304 {ECO:0000313|EMBL:CCE80734.1, ECO:0000313|Proteomes:UP000005222};
RN [1] {ECO:0000313|EMBL:CCE80734.1}
RP NUCLEOTIDE SEQUENCE.
RA Genoscope - CEA;
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000005222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL
RC Y-12695 {ECO:0000313|Proteomes:UP000005222};
RX DOI=10.1534/g3.111.000745;
RA Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J., Seret M.L.,
RA Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT genome resolution following polyploidization.";
RL G3 (Bethesda) 2:299-311(2012).
CC -!- SIMILARITY: Belongs to the eIF-2-beta/eIF-5 family.
CC {ECO:0000256|ARBA:ARBA00010397}.
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DR EMBL; FO082053; CCE79969.1; -; Genomic_DNA.
DR EMBL; FO082052; CCE80734.1; -; Genomic_DNA.
DR AlphaFoldDB; G8YH32; -.
DR STRING; 559304.G8YH32; -.
DR eggNOG; KOG2767; Eukaryota.
DR HOGENOM; CLU_026663_1_0_1; -.
DR InParanoid; G8YH32; -.
DR OMA; CMHQAHL; -.
DR Proteomes; UP000005222; Chromosome G.
DR Proteomes; UP000005222; Chromosome H.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd11561; W2_eIF5; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.20.25.350; -; 1.
DR Gene3D; 3.30.30.170; -; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045196; IF2/IF5.
DR InterPro; IPR002735; Transl_init_fac_IF2/IF5_dom.
DR InterPro; IPR016189; Transl_init_fac_IF2/IF5_N.
DR InterPro; IPR016190; Transl_init_fac_IF2/IF5_Zn-bd.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23001; EUKARYOTIC TRANSLATION INITIATION FACTOR; 1.
DR PANTHER; PTHR23001:SF7; EUKARYOTIC TRANSLATION INITIATION FACTOR 5; 1.
DR Pfam; PF01873; eIF-5_eIF-2B; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00653; eIF2B_5; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF100966; Translation initiation factor 2 beta, aIF2beta, N-terminal domain; 1.
DR SUPFAM; SSF75689; Zinc-binding domain of translation initiation factor 2 beta; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000005222}.
FT DOMAIN 237..398
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 138..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 398 AA; 43988 MW; AFF538447E924F37 CRC64;
MSFVNICRDN TDPFYRYKMP LIQSKVEGRG NGIKTAIVNL PEVARALGRP TSYLIKYFGY
ELGAQTNEER NLVNGSHNAN ELQDSLDGFI SKFVLCPKCR NPETQIQIKD KNILLRNCQA
CGNIADIDPR HKLSSYILKN PPDGAKGGKK GKKSATATAN VVGGGKSISD IASGQANEDG
SQPLATEDDD DALTKKINAE AAALGNDTIE VNDDDWAVDM SKEAIEARAR ELEALSLNDG
QSKFNDLGEW LLNTGKDSKD DLPSDVEIYK KIAELDIIES PETIQVLAQV LFDDDILEQI
EEHLGLLAKL INHNEKSEKA FLGGLERYLG LENPSLIPVL PKVLVKVYDK DLISEEVILE
WGSKVSKKYV PKDVSKKVRK AAKPFINWLK EADEEDSE
//
