ID   G8YM46_PICSO            Unreviewed;       235 AA.
AC   G8YM46;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 42.
DE   SubName: Full=Piso0_001947 protein {ECO:0000313|EMBL:CCE88442.1};
GN   Name=Piso0_001947 {ECO:0000313|EMBL:CCE88442.1};
GN   ORFNames=GNLVRS01_PISO0F01391g {ECO:0000313|EMBL:CCE88442.1};
OS   Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC
OS   10061 / NRRL Y-12695) (Hybrid yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Millerozyma.
OX   NCBI_TaxID=559304 {ECO:0000313|EMBL:CCE88442.1, ECO:0000313|Proteomes:UP000005222};
RN   [1] {ECO:0000313|Proteomes:UP000005222}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL
RC   Y-12695 {ECO:0000313|Proteomes:UP000005222};
RX   DOI=10.1534/g3.111.000745;
RA   Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA   Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA   Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA   Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA   Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J., Seret M.L.,
RA   Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA   Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA   Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT   "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT   genome resolution following polyploidization.";
RL   G3 (Bethesda) 2:299-311(2012).
CC   -!- SIMILARITY: Belongs to the FAH family. {ECO:0000256|ARBA:ARBA00010211}.
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DR   EMBL; FO082054; CCE88442.1; -; Genomic_DNA.
DR   AlphaFoldDB; G8YM46; -.
DR   STRING; 559304.G8YM46; -.
DR   eggNOG; KOG1535; Eukaryota.
DR   HOGENOM; CLU_028458_5_0_1; -.
DR   InParanoid; G8YM46; -.
DR   OMA; MKKQGRP; -.
DR   Proteomes; UP000005222; Chromosome F.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.850.10; Fumarylacetoacetase-like, C-terminal domain; 1.
DR   InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR   InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR   PANTHER; PTHR11820; ACYLPYRUVASE; 1.
DR   PANTHER; PTHR11820:SF7; ACYLPYRUVASE FAHD1, MITOCHONDRIAL; 1.
DR   Pfam; PF01557; FAA_hydrolase; 1.
DR   SUPFAM; SSF56529; FAH; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005222}.
FT   DOMAIN          12..206
FT                   /note="Fumarylacetoacetase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01557"
SQ   SEQUENCE   235 AA;  25799 MW;  DD8FBE8B9DDC58B2 CRC64;
     MSGLKYIGQA GKILCIGRNY AAHIKELNNA TPSEPFFFLK PRSSVLKPGE GPFLVPKGVV
     VHHEVELAFI LSKTLKNLSP SFSREEALDA IEGYALAVDM TARNVQDEAK KKGLPWTIGK
     GFDTFLPLSN FIPKSSIPDP YNVELSLSVN GSIRQQDKTN LMLFPIHKIL SYMSSIMTLE
     KGDLILTGTP KGVGPINPGD NFKATLSIDD KVLDDATIEL EAQEKPGFYD FSKKV
//