ID   G8YQ62_PICSO            Unreviewed;       699 AA.
AC   G8YQ62;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Piso0_000826 protein {ECO:0000313|EMBL:CCE78797.1};
GN   Name=Piso0_000826 {ECO:0000313|EMBL:CCE78797.1};
GN   ORFNames=GNLVRS01_PISO0D04975g {ECO:0000313|EMBL:CCE78797.1};
OS   Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC
OS   10061 / NRRL Y-12695) (Hybrid yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Millerozyma.
OX   NCBI_TaxID=559304 {ECO:0000313|EMBL:CCE78797.1, ECO:0000313|Proteomes:UP000005222};
RN   [1] {ECO:0000313|Proteomes:UP000005222}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL
RC   Y-12695 {ECO:0000313|Proteomes:UP000005222};
RX   DOI=10.1534/g3.111.000745;
RA   Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA   Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA   Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA   Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA   Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J., Seret M.L.,
RA   Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA   Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA   Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT   "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT   genome resolution following polyploidization.";
RL   G3 (Bethesda) 2:299-311(2012).
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766}.
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DR   EMBL; FO082056; CCE78797.1; -; Genomic_DNA.
DR   AlphaFoldDB; G8YQ62; -.
DR   STRING; 559304.G8YQ62; -.
DR   MEROPS; M24.A10; -.
DR   eggNOG; KOG2413; Eukaryota.
DR   HOGENOM; CLU_011781_2_6_1; -.
DR   InParanoid; G8YQ62; -.
DR   OMA; VHEYPPS; -.
DR   Proteomes; UP000005222; Chromosome D.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   CDD; cd01085; APP; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR033740; Pept_M24B.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005222}.
FT   DOMAIN          74..213
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          412..627
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          638..698
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
SQ   SEQUENCE   699 AA;  78849 MW;  52494C71C41AAA93 CRC64;
     MKKVSRAQCA NCTCSPGLLS RSNRRTSWLA KQVNIKRGSV SGSPRSLSRN GSVYTIDAAS
     LCLPEVKEVN TSDRLTRLRQ LMAEYDVGVY IVPSEDEHQS EYVAPGDQKR SFISGFSGSA
     GFAIITRDVM CMNDTPEGLA ALSTDSRYFS QATNELDFNW TLLRQGAKDQ PSWEEWAVLQ
     AINLSLDSGH KISIGVDPRL ITYSLFQKFD GIIRENLAQS KYSRAEVELT PIADNLIANI
     WKEFEEEPPK PDTIIKLLDT KYTGQDVTAK IENTVSIMRK NGCTGLVVSA LDEIAWLLNM
     RGSDIDYNPV FFSYLLLGAD NTATLFADNK RFDTPVRDFL QKHKVNVKPY EQFWTELESF
     SRDLNMKNEK LLVPKNASWE IVRNIKCTFE QPLISPIEDL KSVKNEVELK GAREAHFKDG
     RALCRFFAWL EYELKYNCEL IDEIQADEKL TEFRKMEKNF IGLSFASISA TGANGAMIHY
     KPMKGACSVI NPNKLYLNDS GSQFLEGTTD VTRTVHVGVP TEDEILKYTL VLKGHVALAQ
     LKFPENTTGS SVDVIARQYL WSHGLDYGHG TSHGVGAFLN VHEGPIGIGS RPSASNKLVP
     GHLISNEPGY YEDSEFGIRI ENVMYVKDSG YICNGKRFLE FDTLTRVPFC RDLIKPELLS
     PSEKEWINKY HSTIWNELSP SFVKCTVEYA WLKRQTMPF
//