ID G8YUP8_PICSO Unreviewed; 726 AA.
AC G8YUP8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE SubName: Full=Piso0_000167 protein {ECO:0000313|EMBL:CCE72581.1};
GN Name=Piso0_000167 {ECO:0000313|EMBL:CCE72581.1};
GN ORFNames=GNLVRS01_PISO0A03410g {ECO:0000313|EMBL:CCE72581.1};
OS Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC
OS 10061 / NRRL Y-12695) (Hybrid yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Millerozyma.
OX NCBI_TaxID=559304 {ECO:0000313|EMBL:CCE72581.1, ECO:0000313|Proteomes:UP000005222};
RN [1] {ECO:0000313|Proteomes:UP000005222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL
RC Y-12695 {ECO:0000313|Proteomes:UP000005222};
RX DOI=10.1534/g3.111.000745;
RA Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J., Seret M.L.,
RA Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT genome resolution following polyploidization.";
RL G3 (Bethesda) 2:299-311(2012).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO082059; CCE72581.1; -; Genomic_DNA.
DR AlphaFoldDB; G8YUP8; -.
DR STRING; 559304.G8YUP8; -.
DR eggNOG; KOG1979; Eukaryota.
DR HOGENOM; CLU_004131_2_0_1; -.
DR InParanoid; G8YUP8; -.
DR OMA; ANYHVKK; -.
DR Proteomes; UP000005222; Chromosome A.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000005222}.
FT DOMAIN 232..364
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 422..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 726 AA; 82023 MW; 403B56B03DA57043 CRC64;
MEQSLSKDST DARRIKRLDD SVVNRIAAGE IIVQPANALK ELLENSIDAG STMIEILVKE
GGLKLLQITD NGHGIDKDDM NILCERFTTS KIEKYDDLER ISTYGFRGEA LASISHISRL
SVTSKTKASP LAYKCQYVNG QLANSNGRSD PNAEPKPVAG KDGTQITVED LFYNVPSRLK
SFRSKSDEFS KIVDVVTRYA VHTKRVGFSC KKFGEPYLVL STRPQATTED KIRTLYGSEI
ASELLSINLT GDELSGTEGS PAQDFGLLEV TGFVSNASYL NKKKITHIFF INDRLVSCNP
LKRIINSVYQ FFLPKGSHPF VYLSLKIKPE NIDVNIHPTK RELRFLHEDD IMELIRDKLH
SLLAATDYSR KFRSQNAISS IKRRPDLEET DGSSYASQQR IKKYRQENRL VRVDASQAKL
ESFLNKEPST TEDTQSPGGD QNLSTGKQDD EMNVGPDASI SQSSYSYNDT EWTDVKLSSI
IALKKSVSES VDRDLTSIFS SSSYVGIVDE KKRLCCFQSD VRLYVCDYGA VLNELFYQVA
LENFMNYGEI HLGDGVALEQ VLLALYQSTN EQLKPIEEVI LQIWDMKEMF EAYFKIKVYE
HEGEHRVSCL PLIAKDITFT MSKLPFFFYR LGSLIDYEDE KTCLEGIIRE LALLHIPEPL
ATDEGSEDSS VEHDNNLLSK KEALEHYLEH RVFPLIKQKF LAPKEVDSAV VQIADLPGLY
KVFERC
//
