ID G8YUW1_PICSO Unreviewed; 823 AA.
AC G8YUW1;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Peptide hydrolase {ECO:0000256|RuleBase:RU361240};
DE EC=3.4.-.- {ECO:0000256|RuleBase:RU361240};
GN Name=Piso0_000233 {ECO:0000313|EMBL:CCE72644.1};
GN ORFNames=GNLVRS01_PISO0A04862g {ECO:0000313|EMBL:CCE72644.1};
OS Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC
OS 10061 / NRRL Y-12695) (Hybrid yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Millerozyma.
OX NCBI_TaxID=559304 {ECO:0000313|EMBL:CCE72644.1, ECO:0000313|Proteomes:UP000005222};
RN [1] {ECO:0000313|Proteomes:UP000005222}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL
RC Y-12695 {ECO:0000313|Proteomes:UP000005222};
RX DOI=10.1534/g3.111.000745;
RA Leh Louis V., Despons L., Friedrich A., Martin T., Durrens P.,
RA Casaregola S., Neuveglise C., Fairhead C., Marck C., Cruz J.A.,
RA Straub M.L., Kugler V., Sacerdot C., Uzunov Z., Thierry A., Weiss S.,
RA Bleykasten C., De Montigny J., Jacques N., Jung P., Lemaire M., Mallet S.,
RA Morel G., Richard G.F., Sarkar A., Savel G., Schacherer J., Seret M.L.,
RA Talla E., Samson G., Jubin C., Poulain J., Vacherie B., Barbe V.,
RA Pelletier E., Sherman D.J., Westhof E., Weissenbach J., Baret P.V.,
RA Wincker P., Gaillardin C., Dujon B., Souciet J.L.;
RT "Pichia sorbitophila, an interspecies yeast hybrid reveals early steps of
RT genome resolution following polyploidization.";
RL G3 (Bethesda) 2:299-311(2012).
CC -!- SIMILARITY: Belongs to the peptidase M28 family.
CC {ECO:0000256|RuleBase:RU361240}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FO082059; CCE72644.1; -; Genomic_DNA.
DR AlphaFoldDB; G8YUW1; -.
DR STRING; 559304.G8YUW1; -.
DR eggNOG; KOG2195; Eukaryota.
DR HOGENOM; CLU_005688_2_0_1; -.
DR InParanoid; G8YUW1; -.
DR OMA; YYSYDWL; -.
DR Proteomes; UP000005222; Chromosome A.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU361240};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|RuleBase:RU361240};
KW Protease {ECO:0000256|RuleBase:RU361240};
KW Reference proteome {ECO:0000313|Proteomes:UP000005222};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|RuleBase:RU361240}.
FT TRANSMEM 63..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 407..492
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 823 AA; 94551 MW; BFE69E336C19DFB2 CRC64;
MSESRDEARG SVGEATSLLS PYEGDANSNY GSMEGNQSHD ASEVSSKLDE FQKKVFRFSK
RRFWWSCFLG MVCLLIMHLS FLPRTSLSRD LRRLHGMRLT KSDVQFNFLY FTGLGYADGN
RNEEYVNSWL KDLSTKSGSA SVNYAGCNND ELVNYVERVF RDLGFTPTKQ VFTNKKLKKP
VHSSLRLIDK VSGQIIYDAP MLEKGHDTPA FFTFGKSGKT QQEYIYVNEG TVKDYETLKN
RGFSIEGKIV ISKVSELPTF EKLRIAERSG AVGALFYIPP SNSDIFSRRA FARDYGGARN
TSDLDNIITA NIPAAPISYE SIEPILETLG SNDIANFDGW NFYPEEVKKS FVLELSTEFD
DKSETKMVNI EGTIKGIFED GEIIIGASRD SLTNSNPLSN HAVLFDILRN IQKIRKLGWK
PWRTIRFISW DGSHSALSGS THFLQHFQGK SPILAYVNLD SSVVAGSNFQ VDATPYFNQI
LMKTSRYIPL EFSLDKRDAE SDNNKNLNSA GKIFEKASES PESILTLYDY WKRQDNITIS
NLISQNLKNN DAVNFQNAFN TPIINVKFSN NALRDPFFQE GSNYFSYNWF FQRNVDPFFI
LHGSLIRYIG LLILTLAEQE VIRYDLTSYS LAIEGYYKDF LDKNNHTLNE WYSRPIDEKV
IEDTKLLSDL KGRDSDSIIT LLKVSRMFSN LLSEVSKSAK VFDAYRKNLE LEYTQDFAWY
TSIKKLKIYA QLKLTNYKFL RLEKELTLNQ NDFEFLDMTC GKTCFNHIIY GVDSLYYRES
PQNEKLSAFA YLYSRVQNND FDGLVKYLAI LYEKMTYYNK RLT
//
