ID G9EQ56_9GAMM Unreviewed; 422 AA.
AC G9EQ56;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=GTP cyclohydrolase II {ECO:0008006|Google:ProtNLM};
GN ORFNames=LDG_7402 {ECO:0000313|EMBL:EHL30631.1};
OS Legionella drancourtii LLAP12.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=658187 {ECO:0000313|EMBL:EHL30631.1, ECO:0000313|Proteomes:UP000002770};
RN [1] {ECO:0000313|EMBL:EHL30631.1, ECO:0000313|Proteomes:UP000002770}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LLAP12 {ECO:0000313|EMBL:EHL30631.1,
RC ECO:0000313|Proteomes:UP000002770};
RX PubMed=22047552; DOI=10.1186/1471-2164-12-542;
RA Gimenez G., Bertelli C., Moliner C., Robert C., Raoult D., Fournier P.E.,
RA Greub G.;
RT "Insight into cross-talk between intra-amoebal pathogens.";
RL BMC Genomics 12:542-542(2011).
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DR EMBL; JH413828; EHL30631.1; -; Genomic_DNA.
DR RefSeq; WP_006871311.1; NZ_JH413828.1.
DR AlphaFoldDB; G9EQ56; -.
DR STRING; 658187.LDG_7402; -.
DR eggNOG; COG0807; Bacteria.
DR HOGENOM; CLU_029639_1_0_6; -.
DR InParanoid; G9EQ56; -.
DR OrthoDB; 5482269at2; -.
DR UniPathway; UPA00275; -.
DR Proteomes; UP000002770; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003935; F:GTP cyclohydrolase II activity; IEA:InterPro.
DR GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00641; GTP_cyclohydro2; 1.
DR Gene3D; 3.40.50.10990; GTP cyclohydrolase II; 1.
DR InterPro; IPR022163; GTP_CH_N.
DR InterPro; IPR032677; GTP_cyclohydro_II.
DR InterPro; IPR000926; RibA.
DR InterPro; IPR036144; RibA-like_sf.
DR PANTHER; PTHR47259; -; 1.
DR PANTHER; PTHR47259:SF2; URACIL-REGULATED PROTEIN 1; 1.
DR Pfam; PF12471; GTP_CH_N; 1.
DR Pfam; PF00925; GTP_cyclohydro2; 1.
DR SUPFAM; SSF142695; RibA-like; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002770}.
FT DOMAIN 13..201
FT /note="GTP cyclohydrolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12471"
FT DOMAIN 228..377
FT /note="GTP cyclohydrolase II"
FT /evidence="ECO:0000259|Pfam:PF00925"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 422 AA; 46789 MW; 63ACB1B5315D973A CRC64;
MTHEDVKKKS KRHIVLSSHP SGQTAPSLKI KWGAENAKER GPIIASLTNI RNRNAVGTHS
GSYSVYRALA VAAGVLDPEH VPDLTDTTPP VAIGPHPQWH DAQKIISLDP WGHLVATEFA
DEIKAGYDIR PTIAVTKAHI NIPELHTAMQ QGRLKPDGKI LKESGDVTVT KAAIEPVWYL
PGIAERFAIS ESFLRRTLFE QTAGMFPELV TRTDLDVFLP PIGGLTAYFF GDVTTIHDPK
IELTCRIHDE CNGSDVFGSD ICTCRPYLTH GIELCIESAQ KGGAGLIVYN RKEGRALGEV
TKFLVYNARK RQKGGDTAAK YFERTECVAG VQDMRFQELM CDVLHWLGIT KIHRFVSMSN
MKFDSLQKSG INVIERVKIP DELVPPDAQV EMSAKRAAGY YSPDRIVDIN ELAETKGREL
HE
//
