ID G9KX46_MUSPF Unreviewed; 1264 AA.
AC G9KX46;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Valine--tRNA ligase {ECO:0000256|ARBA:ARBA00024407};
DE EC=6.1.1.9 {ECO:0000256|ARBA:ARBA00013169};
DE AltName: Full=Valyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00029936};
DE Flags: Fragment;
GN Name=VARS1 {ECO:0000313|Ensembl:ENSMPUP00000010733.1,
GN ECO:0000313|RefSeq:XP_004780995.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|EMBL:AES09475.1};
RN [1] {ECO:0000313|EMBL:AES09475.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Lungs {ECO:0000313|EMBL:AES09475.1};
RX PubMed=23236062; DOI=10.1128/JVI.02476-12;
RA Leon A.J., Banner D., Xu L., Ran L., Peng Z., Yi K., Chen C., Xu F.,
RA Huang J., Zhao Z., Lin Z., Huang S.H., Fang Y., Kelvin A.A., Ross T.M.,
RA Farooqui A., Kelvin D.J.;
RT "Sequencing, annotation, and characterization of the influenza ferret
RT infectome.";
RL J. Virol. 87:1957-1966(2013).
RN [2] {ECO:0000313|Ensembl:ENSMPUP00000010733.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_004780995.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004780995.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR EMBL; AEYP01101422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JP020877; AES09475.1; -; mRNA.
DR RefSeq; XP_004780995.1; XM_004780938.3.
DR STRING; 9669.ENSMPUP00000010733; -.
DR Ensembl; ENSMPUT00000010912.1; ENSMPUP00000010733.1; ENSMPUG00000010821.1.
DR GeneID; 101671544; -.
DR CTD; 7407; -.
DR eggNOG; KOG0432; Eukaryota.
DR eggNOG; KOG0867; Eukaryota.
DR GeneTree; ENSGT00940000157775; -.
DR HOGENOM; CLU_001493_0_1_1; -.
DR OMA; LDTWMDS; -.
DR OrthoDB; 5473263at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004832; F:valine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0006438; P:valyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07962; Anticodon_Ia_Val; 1.
DR CDD; cd10294; GST_C_ValRS_N; 1.
DR CDD; cd00817; ValRS_core; 1.
DR Gene3D; 1.20.1050.10; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR Gene3D; 1.10.287.380; Valyl-tRNA synthetase, C-terminal domain; 1.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR HAMAP; MF_02004; Val_tRNA_synth_type1; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033705; Anticodon_Ia_Val.
DR InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR InterPro; IPR036282; Glutathione-S-Trfase_C_sf.
DR InterPro; IPR004046; GST_C.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR037118; Val-tRNA_synth_C_sf.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR InterPro; IPR002303; Valyl-tRNA_ligase.
DR NCBIfam; TIGR00422; valS; 1.
DR PANTHER; PTHR11946:SF115; VALINE--TRNA LIGASE; 1.
DR PANTHER; PTHR11946; VALYL-TRNA SYNTHETASES; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00043; GST_C; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR PRINTS; PR00986; TRNASYNTHVAL.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF47616; GST C-terminal domain-like; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
DR PROSITE; PS50405; GST_CTER; 1.
PE 2: Evidence at transcript level;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715}.
FT DOMAIN 89..224
FT /note="GST C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50405"
FT REGION 218..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1201..1263
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 233..249
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..276
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AES09475.1"
FT NON_TER 1264
FT /evidence="ECO:0000313|EMBL:AES09475.1"
SQ SEQUENCE 1264 AA; 140330 MW; DDDA3426177ACF0B CRC64;
MSILYVSPHP DAFPSLRALI AARYGEAGEG PGWGGAHPRI CLQPPPTSRA PFPPPRLPAL
EQGPGGLWVW GATAVAQLLW PAGLGGPGGS RAAVLVQQWV SYADTELIPA ACGATLPALG
LRTSTQDPQA ALGALGRALS PLEEWLRLHT YLAGEAPTLA DLAAVTALLL PFRYVLDPSA
RRIWGNVTRW FITCVQQPEF RAVLGEVVLY SGARPLSQQP GPEVLVPPKT ATQLKKEAKK
REKLEKFQQK QKTQQQQPPP AEKKPKPEKR GKRDPGVITY DLPTPAGEKK DVSGTMPDSY
SPQYVEAAWY PWWEQQGFFK PEYGRSSVSA PNPRGIFMMC IPPPNVTGSL HLGHALTNAI
QDSLTRWHRM RGETTLWNPG CDHAGIATQV VVEKKLWREQ GLSRHQLGRE AFLQEVWKWK
EEKGDRIYHQ LKKLGSSLDW NRACFTMDPK LSTAVTEAFV RLHEEGVIYR STRLVNWSCT
LNSAISDIEV DKKELTGRTL LSVPGYKEKV EFGVLVSFAY KIQGSDSDEE VVVATTRIET
MLGDVAVAVH PKDPRYQNLK GRSVIHPFLS RSLPIVFDDF VDMEFGTGAV KITPAHDQND
YEVGQRHGLE AVSIMDSRGA LVNVPPPFLG LPRFEARKAV LAALKERGLF RGVEDNPMVV
PLCNRSKDVV EPLLRPQWYV RCGEMAQAAS AAVTRGDLRI LPEAHQRTWH TWMDNIRDWC
ISRQLWWGHR IPAYFVTVSD PAVPPGEDPD ERYWVSGRSE AEAREKAAKE FGVSPDKISL
QQDEDVLDTW FSSGLFPFSI FGWPNQSEDL SVFYPGTLLE TGHDILFFWV ARMVMLGLKL
TGKLPFREVY LHAIVRDAHG RKMSKSLGNV IDPLDVIHGV SLQGLHDQLL SSNLDPSEVE
KAKEGQKADF PAGIPECGTD ALRFGLCAYT SQGRDINLDV NRILGYRHFC NKLWNATKFA
LRGLGKGFVP SPTSKPGGHE SLVDRWIRSR LTEAVRLSNQ GFQAYDFSAV TTAQYSFWLY
ELCDVYLECL KPVLNGVDQV VAECARQTLY TCLDVGLRLL SPFMPFVTEE LFQRLPRRTP
QAPPSLCITP YPEPSECSWK DPDAEAAMEL ALSITRAVRS LRADYNLTRI RPDCFLEVAD
EATGALASAV SGYVQALASA GVVAVLALGA PVPQGCAVAL ASDRCSVHLQ LQGLVDPARE
LGKLQAKRSE AQRQAQRLRE RRAASGYPSK VPLDVQEADR TKLQQTEAEL RKVDEAIALF
QKML
//
