ID G9M9P0_ORYLA Unreviewed; 2706 AA.
AC G9M9P0; H2LH67;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Filamin C {ECO:0000313|EMBL:BAL41502.1, ECO:0000313|Ensembl:ENSORLP00000005322.2};
GN Name=flnc {ECO:0000313|EMBL:BAL41502.1,
GN ECO:0000313|Ensembl:ENSORLP00000005322.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|EMBL:BAL41502.1};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000005322.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005322.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|EMBL:BAL41502.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Qurt {ECO:0000313|EMBL:BAL41502.1};
RA Fujita M., Mitsuhashi H., Isogai S., Nakata T., Kawakami A., Nonaka I.,
RA Noguchi S., Hayashi Y.K., Nishino I., Kudo A.;
RT "Filamin C plays the essential role in the maintenance of the structural
RT integrity of cardiac and skeletal muscles, revealed by the medaka mutant,
RT zacro.";
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSORLP00000005322.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000005322.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR EMBL; AB639344; BAL41502.1; -; mRNA.
DR RefSeq; XP_011474170.1; XM_011475868.1.
DR Ensembl; ENSORLT00000005323.2; ENSORLP00000005322.2; ENSORLG00000004247.2.
DR GeneID; 101165476; -.
DR CTD; 2318; -.
DR eggNOG; KOG0518; Eukaryota.
DR GeneTree; ENSGT00940000153588; -.
DR HOGENOM; CLU_000783_0_0_1; -.
DR OrthoDB; 298396at2759; -.
DR TreeFam; TF313685; -.
DR Proteomes; UP000001038; Chromosome 6.
DR Bgee; ENSORLG00000004247; Expressed in heart and 10 other cell types or tissues.
DR GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 24.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF00630; Filamin; 24.
DR SMART; SM00033; CH; 2.
DR SMART; SM00557; IG_FLMN; 24.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF81296; E set domains; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50194; FILAMIN_REPEAT; 24.
PE 2: Evidence at transcript level;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 43..149
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 166..269
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 282..375
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 377..475
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 476..572
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 573..665
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 669..765
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 766..868
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 869..967
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 968..1063
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1064..1156
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1157..1251
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1252..1351
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1352..1444
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1445..1540
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1541..1637
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1650..1739
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1755..1826
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1826..1918
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1923..2006
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2009..2101
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2196..2281
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2284..2376
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2378..2471
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2475..2567
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2611..2705
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 1770..1791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2706 AA; 290390 MW; 545868CD6FF5A264 CRC64;
MMANNYDDQL PPQYYQATDF GDEEEDEMPA TEKDLAEDAP WKKIQQNTFT RWCNEHLKCV
NKTITDLQKD FSDGLKLISL LEVLSQKKMY RKHHTRPNFR QMKLENVSVA LEFLDREHIK
LVSIDSKAIV DGNLKLILGL IWTLILHYSI SMPMWDDEDD EETKKLTPKQ RLLGWIQNKV
PQLPINNFNR DWRDGKALGA LVDNCAPGLC PDWVDWDPNQ PVQNAKEAMQ QADDWLGVPQ
VIAPEEIVDP DVDEHSVMTY LSQFPKAKLK PGAPLRPKQL FPDKVKAYGP GIEPHGNKVL
HPAVFTVETL EAGSGEVLVF VEDPEGHKEE AKVKPNKDKR GTYTVTYTPK VEGVHKVKVL
FAGQDIDKSP YTVNVDKDMG DPSKVHARGP GLEATGNVAN KPTYFDIYTA GAGNGDISVV
IVDPRGKKDT VELILENKGD SVFRCTYHPV LEGPHTIHIL FAGQEIPRSP FHVNIAEAIN
PNACRATGRG LQPKGVRIRE VADFKVFTKG AGSGTLNVSV KGPTGAEEQV KVRDAGNGVY
ECEYYPLKAG KYTVSITWGG QPIPRSPFEV EVGEEAGFQK VRAWGPGLKT GMVGKSADFV
VEAIGTEVGT LGFSIEGPSQ AKIECDDKGD GSCDVHYWPT EPGDYAVHVI CDDEDIKDSP
FMAHILPAVN NVFPEKVKAY GPGLQPTGVI VNKPTEFTID ARMAGKGHLR IYAQDVEGCT
IDIKITDRGD GTFMCVYTPV KPIKHTIIIT WGEVNVPNSP FRVLVGEGSH PDKVKVFGPG
VEKTGLKANE PTYFTVDCSE AGQGDISIGI KCAPGVVGPA EADIDFDIIK NDNDTFTVKY
TPPAPGRFTI MVLFADQEIP ISPFKVKVDP SHDAGKVRAE GPGLNKTGVE VGTPTHFTIY
TKGAGKAKPE VHFAASGPGE AVRDFEIIDN HDYSYTVKYT ALQQGNMAIS IALGGDTIPK
SPFHITVAPA MDLAKVKVEG LDTKVEVGKD QEFTVNTKGA GGLGNVGVKM TSPSGRPIPC
KLESDKAKGN HSVKYIPPEE GQYKVDVNYD GNPVLGSPFG VEAVMPADPS KVRAFGPGLQ
GGIVGKPAPF TIDTKGAGAG GLGLTVEGPC EAKIECQDNG DGTCSVSYLP TEPGEYAINI
LFAEQHISGS PFKAAIRPAL DPIKVVASGP GLERAKAGEP ATFTVDCSRA GDAELTIEIV
SETGVKAEVH IQKTAEGTFS VTYIPSFQGT HTITIKYGGH TIPHFPRVLQ VEPSVDTSGV
HVYGPGVEPR GVLREVTTHF IVDARALIKI GGGHVKVHII NPSGSNTDAY ITDKGDGTYR
VEYTAFEDGI HLIEVLYDDA PVPKSPFRVS VVEGCDPTRV RAFGPGLEGG ITNKPNRFTV
ETRGAGTGGL GLTIEGASEA KISCKDNKDG SCSVEYVPFT PGDYDVNINY GGQPIPGSPF
RVPVKDPVDP TKVKCSGPGL GTGVRAHVPQ NFTVDCTQAG QAPLDVKLYG PTGTVEPVGV
KNNGDGTHTV HYTPAQDGPY TVSVKYSDQE VPHSPFKVMS QPGHDASKVR ASGPGLDIKG
VPASLPVEFT IDARDAGEGL LTVQILDPEG KPKNATIQDN RDGTYTVSYV PDSTGPYTIT
IKYGGDEIPY SPYRIQSLPT GDASKCLLTV SVGGHGMSSL QKLQTSEDTV ITVDAKAAGK
GKVTCKVLTP QGMELDMDVV ENRDGTFDIY YTAPEPGKYV ITIRFGGQNI PKSPFQVMAT
NEPVVPRDTV DPLFRPVNFL VPFTPQQGEI TGEVKMPSGK TARPHITDNK DGTITIKYQP
TERGLHEMDI KYDGNHIPGS PLQFYVDAVN SGVVTAYGPG LSYGMVNKSA TFTVVTKNAG
EGGLSLAVEG PSKAEITCKD NKDGTCTVSY LPTAPGDYNI IVKFDNKHIP GSPFTAKITG
DDSITRTSQL NVGTATDVSL KITETDLSCL TASIRAPSGN EEPCLLKRLP NRHLGISFTP
KEVGEHEVSV RKDGIHVANS PFKIMVGQSE IGEASRVKAF GKGLIEAHTF EMAEFFVDTR
NAGYGGLALS IEGPSKVDIN CEDMEDGTCR VTYCPTEPGS YTVNIKFAEK HIPGSPFAVK
VTGEGRIKES ITRKRQASSL ASVGSTCGLN LKIPGNWFQM VSAQERLTRT FTRSSHTYTR
TERTEISKTR GGETKREVRV EESTQVGGGG SPFRDVFGDF LGRESLSSFA GLTARPEVES
GSQAMTAQVT SPSGKTVDAD IVDGGSSTYS VRFIPQEIGP HTVNVKYRGQ HVPGSPFQFT
VGPMGEGGAH KVRAGGPGLE RGVAGAPSEF SIWTREAGAG GLSIAVEGPS KAEITFEDRK
DGSCGVSYIV KEPGDYEVSI KFNNEHIPDS PFIVPIATLS DEARRLTVTS LQEKDLKVNQ
EASFMVQRNG PRGVVDAKVH TPSGSTEECY VSELDSDKSA IRFIPRENGV HSIDVKFNGC
HIPGSPFNVR VGDPGLIGDP GMVTAHGPGL QGGTTGIPSE FVVKTCNAGS GTLSVNIDGP
SKVKMDCREC PEGYRITYTP MAPGNYLITI KYGGPQHIVG SPFKAKVTGT RLSGGHSLHE
TSSVLVETVT KTSKVGGAYS ASSSSSTTST KLTSDASKVV CRGQGLSKAV VGQKNNFSVD
CSKAGTNMLM VGVHGPHAPC EEVYVKHMGN KLYNVTYTVK DKGSYTVIVK WGDDNVPGSP
YKVSAP
//
