ID G9MDH7_HYPVG Unreviewed; 4871 AA.
AC G9MDH7;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Putative non-ribosomal peptide synthetase {ECO:0000313|EMBL:EHK26839.1};
GN ORFNames=TRIVIDRAFT_85582 {ECO:0000313|EMBL:EHK26839.1};
OS Hypocrea virens (strain Gv29-8 / FGSC 10586) (Gliocladium virens)
OS (Trichoderma virens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=413071 {ECO:0000313|EMBL:EHK26839.1, ECO:0000313|Proteomes:UP000007115};
RN [1] {ECO:0000313|EMBL:EHK26839.1, ECO:0000313|Proteomes:UP000007115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Gv29-8 / FGSC 10586 {ECO:0000313|Proteomes:UP000007115};
RX PubMed=21501500; DOI=10.1186/gb-2011-12-4-r40;
RA Kubicek C.P., Herrera-Estrella A., Seidl-Seiboth V., Martinez D.A.,
RA Druzhinina I.S., Thon M., Zeilinger S., Casas-Flores S., Horwitz B.A.,
RA Mukherjee P.K., Mukherjee M., Kredics L., Alcaraz L.D., Aerts A., Antal Z.,
RA Atanasova L., Cervantes-Badillo M.G., Challacombe J., Chertkov O.,
RA McCluskey K., Coulpier F., Deshpande N., von Doehren H., Ebbole D.J.,
RA Esquivel-Naranjo E.U., Fekete E., Flipphi M., Glaser F.,
RA Gomez-Rodriguez E.Y., Gruber S., Han C., Henrissat B., Hermosa R.,
RA Hernandez-Onate M., Karaffa L., Kosti I., Le Crom S., Lindquist E.,
RA Lucas S., Luebeck M., Luebeck P.S., Margeot A., Metz B., Misra M.,
RA Nevalainen H., Omann M., Packer N., Perrone G., Uresti-Rivera E.E.,
RA Salamov A., Schmoll M., Seiboth B., Shapiro H., Sukno S.,
RA Tamayo-Ramos J.A., Tisch D., Wiest A., Wilkinson H.H., Zhang M.,
RA Coutinho P.M., Kenerley C.M., Monte E., Baker S.E., Grigoriev I.V.;
RT "Comparative genome sequence analysis underscores mycoparasitism as the
RT ancestral life style of Trichoderma.";
RL Genome Biol. 12:R40.1-R40.15(2011).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK26839.1}.
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DR EMBL; ABDF02000001; EHK26839.1; -; Genomic_DNA.
DR RefSeq; XP_013961058.1; XM_014105583.1.
DR STRING; 413071.G9MDH7; -.
DR EnsemblFungi; EHK26839; EHK26839; TRIVIDRAFT_85582.
DR GeneID; 25798606; -.
DR VEuPathDB; FungiDB:TRIVIDRAFT_85582; -.
DR eggNOG; KOG1176; Eukaryota.
DR eggNOG; KOG1178; Eukaryota.
DR HOGENOM; CLU_000092_2_0_1; -.
DR InParanoid; G9MDH7; -.
DR OMA; HHIVTEG; -.
DR OrthoDB; 1778695at2759; -.
DR Proteomes; UP000007115; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR CDD; cd05918; A_NRPS_SidN3_like; 2.
DR CDD; cd19542; CT_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 7.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 3.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 6.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF00668; Condensation; 6.
DR Pfam; PF00550; PP-binding; 6.
DR SMART; SM00823; PKS_PP; 6.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 6.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 12.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 6.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 6.
PE 4: Predicted;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007115}.
FT DOMAIN 529..602
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1591..1668
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2134..2210
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3214..3288
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3758..3834
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4317..4390
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 4871 AA; 539683 MW; 25AD2AD3AAADB9ED CRC64;
MEAPADLSVL NPHPTLLPGP DLLHHLIREP DDSIALDYTG RNKRVSLSYR QLHDAADALA
SRICRAFGET KDQFVVPVLV HQSPHLYIAL LAILKAGGAF CPLNVDAPPD RVNFIFNDVS
AAVVVASAEL ASRIPPQSAV KVLLVDEDEE EKSLDIEPAN CRAPSTKDLA YVMYTSGSTG
VPKGVGISHS AVTQALLAHN QHVPTFSRFL QFAAPTFDVS VFEIFFPLFR GSTLISVDRK
EMLNDLPEVI SSMGVDACEL TPTVAASLLR KRENVPTLQL LLTIGEMLNE PVIREFGGSQ
DRESILWAMY GPTEATIHCT VQEAFSSTSS IKNIGVQLPT VSCFIIEPAE TAEASRNAKI
LPKGEIGELA VGGYQLADGY LNRQEQTASS FIPSPYGLIY RTGDKARISS DGTIEIYGRL
SEGQVKLRGQ RLELGEVQSA VLKTPGCHLA VGAVIDSILV VFCVADTGVT EDLIMNQCRS
WLPQFMMPGE LVLMDEFPRL PSGKVDTKRL KAEFIEQKAA GRGQSDSSIA LSDTEKTILR
VISDTLGAEA NYDMTLASAG IDSLVAIKLA SSLRSSGFSV SVAELLSMQT IAQLCSAVRP
LSSLTHYEAS LIDIHLMDNL DSIAESNAAL QKDLELVEDV LQCSPLQVAM LSETVQRLEA
YWNEIELEAN PGITATEIQD AFHLLARQRD ILRAGFVNWQ GSFVSPIFKS LRSDQIEVVE
EFHQLELSGD ETLLRPLRIQ IQQARSDAGP RLLINIHHAI YDGWSMDIIL SDLSTVLYGR
PLPPRPQFSN LLAYTSNIPR DQMDSARAFW AEYLVDWNKP SRPKLSARPA EFDETLVVKT
QLDIPAEAAQ EVFTNTRYGA QVYFQAALAI IWGSMVGTSD VLLGSVTSGR TIPVEDVEEI
VGPSIASLPL RVGIDNSATM SDVLRNINES NRKIMEHCLL PLSEIKKLSS LQVTESLYDV
LFVYQESLYT KNRKEAAIRE TRHLDHLETK LLLEVEPNDA GFSMQATYHT EWFPSEMVEI
LVEQVKAAFQ HIIQYPDGLI RTAKDAIATE ASVANTNPEK LQDEVDLATL FEAAAAKTPD
ADAICFSKLL SEVPIIADTM SYESLNHLSN RIARFLLEQG AEPGQVIAIV MQKSPLLYAS
ILGIVKARCA YLPLLPSTPI ERVEDIFKSG SIERCVVDKD SIQSFQGVTD VQFLDVESAS
LDGFANNNLD IPMDMSRLAY VIYTSGTTGV PKGVAVSQKN IVNNVTYLAS VYPSAQRNPA
RLLQACSQAF DVSVFEIFFA WHAGMCLCAA ANDDLFEDLE HSIRQFQITH LSLTPTVASL
IDPKNVPNVE FLVTAGEPMT LSVLDTWGEL LWQGYGPSET TNICSVKRMK PGEYIEHLGW
CFSNTSIFVL SPDGLSTVPI GWIGEFCFGG EQVADGYLNM PDLTAEKFIN HPDYGLIYRS
GDMGRMLPDK SLLILGRIDD QLKLKGQRIE AGEVNSVITS DPSIHAAVTT LVRRESGATN
QLASFYTFSQ GAVDEVLQTL DPDAESHRSL YATLISKLPS YMVPSYLIPV SRIPLTSSGK
VDRRKLQSCF EALSQEYLES VSSTVTMQDD AEWSKAEIMI AEAIARSLNV SRSDIGRWTP
FATIGLDSIS AIGVSRNLNS QLGYRVPISA ILQHSSVAQL ARFLQERSER DGPVKDVVFF
SDSFIHGVHE TFEQAPYSIT GILPCSPLQE AMLSQGSYYN RILLRLHRPV DEMKGYWDEM
TRRHSILRTC FITTDSVQFP IAQVVLDNWT IQWKEFAVTT ASLDEAAHQH VICLSDPLDT
KVPPLSFAII QQEDSIFLSF ICHHALYDGV AMENLWREVE ALAHGEALPP PVSYTPFLQA
ALSLPDDVEK FWSNHFRGYD PLNLFMQPSG SQIVQCAHRE TLDVSYGEIK TRLRSLGVSL
LSICQAAWAT TLSVCSTSTD VCFGLVMNGR TLDIEGLDRL VAPCFNTIPV RKDVSTSSRN
IDLAKSFQRL NSDVQSYQFS PLRLIQKLGT KEGRRLFDTL LLLQSPLQDM DSGIWTLEAD
DGEMDIPVVC EVIPHSSLNA IAINMHYDKS ALSEDIALAL AEIFKSFFQT ILDHPSSALP
DRSHLQPAQL SVLNTVTAKK NTLAASEKPQ ISDAEWTEPE KKIRQVLSSL SGTSIQKIHP
ETSIFQLGLD SINAVQVAAM LRREGFVVSA SDVIECQNCT RLAQRISQTS EDSETTPGYN
FEKFSKEISA QIADKALDAT DIEAVLPSTP LQCAMLVSFI QSQGQNYLNL LSYAVDNIVL
KDDLIAAWKA LQVHHPMLRT GFAAVQHQYS SFAMLRYSSS SDSTESFKHI FHMESQDDLQ
EWKEKEAATI LNNLHIPPWR VSLADINGGI MMNILIHHAL YDARSLDQMM GDLSTLLSGQ
DIAHIRPIEP ALNEILSRSL SDRSTAQEFW TEKAEMAVVN TFPVMTPLRE DERTMLSFEI
RSSATLSSLQ MATMKQGVSI QAIIQAAWTR ILSSYLGEES VVFGVILSGR SMDETKDAPF
PCMNTIPVIA VNQPSNTELT RYMMEYNADA HRHQHTPLTQ IQKWLGHPAT PVFDTLLVYQ
KLETESNITK RWRLVNDDAT VDYPVSLEVK PMDNGEIQLC ITFFSDILPI EQAELLVRQF
DAMMIHIATE PDGDEDGIYQ SKPDLFAITP PFSPELHAPV QFLHHFVEQR AVSHPNDTAL
EFVGKFEGSR PVKQVWTYAE FDAMGDKLAN LLSDVAAIGS IVAIHFDKCP EAYISILGIL
KAGCAFVALD PSAPKDRKEF ILKDSLAPCL LTTSEGNIDF DTDVKVIRID LESVKLLSSE
KRNLGANFTP DATCYCLYTS GTTGTPKGCE ITHDNCVQAM MAFQELFKGH WSDDSRWLQF
AALHFDVSVL EQYWSWSVGI TVVAAPRDLI LDDLIASINN LEITHIDLTP SLARLTHPDE
VPGLCKGVFI TGGEQLKQEI LDAWGPKAVI YNAYGPTEAT IGVTMYQRVP INGRPSNIGK
QFLNVGSYVF RNGTEIPVLR GAVGELCVSG RLVGKGYLNR EELTKERFPT LSEFGEKIYR
TGDLVRILHD GCFDFLGRAD DQVKLRGQRL EIGEINHVIR TGASEIKDVA TIVIKHASSG
KDVLVSFLVG QQRSKAVLAP LVDETNLGAK AKEACRAKLP GYMIPTYFLV LPFIPLSPNN
KVEAKELKKL FNGLSHEQLM DLTAPKAPLR SVNGETGYKV IQVLSDFTCV SSDNIDGETS
IFDLGVDSIS ALQLSTLFKD RGFVACSPAI ILRNPIIADL TTTLFEKLSS SLKDSRVKES
QQMIQAYHHR YRALACSILN LRGEDIEYIA PCSALQQGII SKSVTDEIRG TYFNSFVLKL
NGDAAEERMK AAWSELIVSE SILRTKFVNT TEGYIQVALK NQDLRWIDST VQNEVDAKAF
LDNRWQEWVQ QNSEHITAPI EVIFIKGPDF KKLVIHVFHA IYDGNSFDLM LQKLKSIYEG
NPMASSPTFI EALSHGPLWR HDDCRGFWEN HLQGWKSSTL QLSSPHNPAA SQTRVISGAI
LEDARKKHKV TLQPVILALW TSVLQKYYPE GLTLGLIVSG RSIDLPGVEN TIGPLFNTVP
FFNKALSGQT WASLILRCSE FSTSILPFQH VPLKSIQKWC VGGRQLFDNL FVFEVEQQAA
KDELTLWEIE DGPLNPDYPL ALEAKRLLNG DVQLTLVAQR NVADAPKLQE ILDELDENIR
LLVADVPFPR SIEEDEIPLS VKQNGFKSGD HETDDEVFEW TDQALGIRDA IASLSGLDDA
EISAAKTILE LGLDSIDVIQ LSARLKQRGI LLPASQIMRQ QTIAKMATSI QTQQSDELSN
GNTDWSFEEL EHKLWSYANK VGLSASDIEA VLPPTPLQES MAAGMIHSDF EWYFNHDLLE
ISAGIDVEKL RKAFLVVIDR SPILRTGFLE VDDLQLEMAY CQVVRKHWNH AIESVEVQDL
TEMGDLVEDA KRIAKESSGA DALFQLKFVM CKEKTFILVS IAHALYDGWS LSLLYRDLET
AYYGDLQPRM SAKPFLQKIL ASATDDASRF WAGYLDGVAP SILPASSDDR MTNTLHRKEY
SASKRMSEIS SFCKKQGISL QVLCQACWAL VLAHRIKALD VTFGVVMSGR DFEGAEDLMF
ATINTVALRC ILHGSSVSFL RYLEASMADI REYQSYPLRK IQNAVQLSSS ELFNTLFMLQ
KFPYNSSVNP LLKSVDGASA VDYPVSVEAE AVGDDLVWRV ACQWQFISED GAEKLLEDLN
RVLEFLTNSE EVEILSFQEN GVSIGGLPHI SLTEDVALPD GGEEQSLAIE DEEDEIDETA
LIIRRILSHV SYIPEESIRP QSNLYHLGLD SISAIKLTSL LRKEGIYLNP RDFIRATSIR
QMAQLTTPLQ TNGSTVHPRE TAWAPEGDVD VEKLFASAHI SKEDVEVILP ALPMQVYMVS
AWQNAEGHVF YPEFRYLVEG NVSVEDVYSA WRSLVVQTPI LRTVFIATDD PQQPFLQIIL
KANSLPSDNS AVKPMVRLEA ARREDNKIAI RLKIHHALYD GVSIPIILNR LSELLNGRTL
MVEQGIEEWS RYAIQPPLED SRQSRRAFWI SYLQGCSSDG DSSALVMAGK HRVSHLRKSA
VSDIAYLQTS AKEKGISLQA LFFAAYAKIL ATGSSGVANV DGKKTVVFGI YLANRADEAL
PLAFPALNLV PLRVHLASSD NILEVASMIQ DDIHLIAADG HADVGLWEVA AWTGVTITSF
VNFLSLPDTP SEAPNDISNN IELIPVQSDE HVAQDAFTNG DKEKEEAVSH LCLIKNPVRD
AFPAAIDIEA SIKGKGLDIG IFGSQKRLSD EGAIHLIEEI VSYLEELDDK DGAEMAAWAS
TWLTGNSKKN C
//
