ID G9MI70_HYPVG Unreviewed; 949 AA.
AC G9MI70;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=isoleucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013165};
DE EC=6.1.1.5 {ECO:0000256|ARBA:ARBA00013165};
DE AltName: Full=Isoleucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00032665};
GN ORFNames=TRIVIDRAFT_84998 {ECO:0000313|EMBL:EHK25187.1};
OS Hypocrea virens (strain Gv29-8 / FGSC 10586) (Gliocladium virens)
OS (Trichoderma virens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=413071 {ECO:0000313|EMBL:EHK25187.1, ECO:0000313|Proteomes:UP000007115};
RN [1] {ECO:0000313|EMBL:EHK25187.1, ECO:0000313|Proteomes:UP000007115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Gv29-8 / FGSC 10586 {ECO:0000313|Proteomes:UP000007115};
RX PubMed=21501500; DOI=10.1186/gb-2011-12-4-r40;
RA Kubicek C.P., Herrera-Estrella A., Seidl-Seiboth V., Martinez D.A.,
RA Druzhinina I.S., Thon M., Zeilinger S., Casas-Flores S., Horwitz B.A.,
RA Mukherjee P.K., Mukherjee M., Kredics L., Alcaraz L.D., Aerts A., Antal Z.,
RA Atanasova L., Cervantes-Badillo M.G., Challacombe J., Chertkov O.,
RA McCluskey K., Coulpier F., Deshpande N., von Doehren H., Ebbole D.J.,
RA Esquivel-Naranjo E.U., Fekete E., Flipphi M., Glaser F.,
RA Gomez-Rodriguez E.Y., Gruber S., Han C., Henrissat B., Hermosa R.,
RA Hernandez-Onate M., Karaffa L., Kosti I., Le Crom S., Lindquist E.,
RA Lucas S., Luebeck M., Luebeck P.S., Margeot A., Metz B., Misra M.,
RA Nevalainen H., Omann M., Packer N., Perrone G., Uresti-Rivera E.E.,
RA Salamov A., Schmoll M., Seiboth B., Shapiro H., Sukno S.,
RA Tamayo-Ramos J.A., Tisch D., Wiest A., Wilkinson H.H., Zhang M.,
RA Coutinho P.M., Kenerley C.M., Monte E., Baker S.E., Grigoriev I.V.;
RT "Comparative genome sequence analysis underscores mycoparasitism as the
RT ancestral life style of Trichoderma.";
RL Genome Biol. 12:R40.1-R40.15(2011).
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK25187.1}.
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DR EMBL; ABDF02000003; EHK25187.1; -; Genomic_DNA.
DR RefSeq; XP_013959400.1; XM_014103925.1.
DR AlphaFoldDB; G9MI70; -.
DR STRING; 413071.G9MI70; -.
DR EnsemblFungi; EHK25187; EHK25187; TRIVIDRAFT_84998.
DR GeneID; 25798567; -.
DR VEuPathDB; FungiDB:TRIVIDRAFT_84998; -.
DR eggNOG; KOG0433; Eukaryota.
DR HOGENOM; CLU_001493_7_2_1; -.
DR InParanoid; G9MI70; -.
DR OMA; HCWRCKT; -.
DR OrthoDB; 656at2759; -.
DR Proteomes; UP000007115; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:EnsemblFungi.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR GO; GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
DR GO; GO:0032543; P:mitochondrial translation; IEA:EnsemblFungi.
DR CDD; cd07960; Anticodon_Ia_Ile_BEm; 1.
DR Gene3D; 1.10.730.20; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR Gene3D; 1.10.10.830; Ile-tRNA synthetase CP2 domain-like; 1.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR033708; Anticodon_Ile_BEm.
DR InterPro; IPR002301; Ile-tRNA-ligase.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR NCBIfam; TIGR00392; ileS; 1.
DR PANTHER; PTHR42765:SF1; ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR42765; SOLEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR PRINTS; PR00984; TRNASYNTHILE.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000007115}.
FT DOMAIN 35..659
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 700..783
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 949 AA; 105340 MW; AFB50FE0086A4725 CRC64;
MSKSWKSTLR LPRSSFPARP NPKLQQQLLR DCTDSFYQWQ TNNRPKENPF VLHDGPPYAN
GPLHAGHAIN KTLKDMINRI QVQGGRRVMY RPSWDCHGLP IEMKALGESG TKGLSPPKIR
ESARRLASKT ILDQMKGFQS FAVMSEWDNK WTTMDRAFEI RQLRVFQKMV RSGLIYRKHK
PVYWSTSSRT ALAEAELEYR DDHVSTAAYV RFPIMSDWSS IPGLSEFKGQ LYAAIWTTTP
WTLPANKAIA VHNELDYVLL QVGNDGILVA ESRVEEIQKN IPSAAVIAKS IPGSQLTGLL
YRNKLRGSAS SLQPIVHAEF VSADSGTGLV HMAPGHGQED YQACSALGIE AFAPITDEGH
FTPEAYPDDP EKLTSGPSIL DGGSQAVLEL VGQDVLWTHK LQHKYPYDWR TKKPVVIRAT
AQWFADVGSI KEDALQALGQ VRFVPESGRV RLESFVKGRS EWCISRQRSW GVPIPALYDE
SGNAVMTDES IEHIISVMEQ KTSDAWFSDA PDDAAWIAPS LKGTYRRGTD TMDVWFDSGS
SWTEIGRPVD VYLEGSDQHR GWFQSSLLTF VAAQKADGKA GADIAPPFGT LITHGFTLDA
QGKKMSKSLG NTIVPSEIME GKLLPPLKSK GNDAATRFDA LGTDALRLWA ASSDFTSDIL
VGASILQPIH SALIKYRTTL KMLLGSLHQS ALEAPLTKLD QIAILQLQDV MAQVWEAYSN
YEFHKAAGLI NRWIATDLSA FYLEGLKDRL YCGDGGDVLV PILVGFLRML APITPMLVEE
AWSHRPSWMV EDASFEHPAR QLYNSHVIDP ARLTLDQAQL RLHLPILSAV HDAVKAGLEQ
GRESKALGSS LQCSLNISVT DDRLAAVLKE YLDELDAMFV VSSVELNSPL SPDNHDWCYS
KEFTVDGMQG VVHVLPPKQS KCSRCWRYVA EEEDGLCGRC EDVTAATAS
//
