ID G9MXV2_HYPVG Unreviewed; 1373 AA.
AC G9MXV2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Dicer-like protein 1 {ECO:0000256|ARBA:ARBA00020797};
DE Flags: Fragment;
GN ORFNames=TRIVIDRAFT_171147 {ECO:0000313|EMBL:EHK20713.1};
OS Hypocrea virens (strain Gv29-8 / FGSC 10586) (Gliocladium virens)
OS (Trichoderma virens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=413071 {ECO:0000313|EMBL:EHK20713.1, ECO:0000313|Proteomes:UP000007115};
RN [1] {ECO:0000313|EMBL:EHK20713.1, ECO:0000313|Proteomes:UP000007115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Gv29-8 / FGSC 10586 {ECO:0000313|Proteomes:UP000007115};
RX PubMed=21501500; DOI=10.1186/gb-2011-12-4-r40;
RA Kubicek C.P., Herrera-Estrella A., Seidl-Seiboth V., Martinez D.A.,
RA Druzhinina I.S., Thon M., Zeilinger S., Casas-Flores S., Horwitz B.A.,
RA Mukherjee P.K., Mukherjee M., Kredics L., Alcaraz L.D., Aerts A., Antal Z.,
RA Atanasova L., Cervantes-Badillo M.G., Challacombe J., Chertkov O.,
RA McCluskey K., Coulpier F., Deshpande N., von Doehren H., Ebbole D.J.,
RA Esquivel-Naranjo E.U., Fekete E., Flipphi M., Glaser F.,
RA Gomez-Rodriguez E.Y., Gruber S., Han C., Henrissat B., Hermosa R.,
RA Hernandez-Onate M., Karaffa L., Kosti I., Le Crom S., Lindquist E.,
RA Lucas S., Luebeck M., Luebeck P.S., Margeot A., Metz B., Misra M.,
RA Nevalainen H., Omann M., Packer N., Perrone G., Uresti-Rivera E.E.,
RA Salamov A., Schmoll M., Seiboth B., Shapiro H., Sukno S.,
RA Tamayo-Ramos J.A., Tisch D., Wiest A., Wilkinson H.H., Zhang M.,
RA Coutinho P.M., Kenerley C.M., Monte E., Baker S.E., Grigoriev I.V.;
RT "Comparative genome sequence analysis underscores mycoparasitism as the
RT ancestral life style of Trichoderma.";
RL Genome Biol. 12:R40.1-R40.15(2011).
CC -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC {ECO:0000256|PROSITE-ProRule:PRU00657}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK20713.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABDF02000078; EHK20713.1; -; Genomic_DNA.
DR RefSeq; XP_013954908.1; XM_014099433.1.
DR STRING; 413071.G9MXV2; -.
DR EnsemblFungi; EHK20713; EHK20713; TRIVIDRAFT_171147.
DR GeneID; 25788768; -.
DR VEuPathDB; FungiDB:TRIVIDRAFT_171147; -.
DR eggNOG; KOG0701; Eukaryota.
DR HOGENOM; CLU_000907_4_3_1; -.
DR InParanoid; G9MXV2; -.
DR OMA; YHVNRMC; -.
DR OrthoDB; 342391at2759; -.
DR Proteomes; UP000007115; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0050688; P:regulation of defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd00593; RIBOc; 2.
DR Gene3D; 3.30.160.380; Dicer dimerisation domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 2.
DR InterPro; IPR038248; Dicer_dimer_sf.
DR InterPro; IPR005034; Dicer_dimerisation_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000999; RNase_III_dom.
DR InterPro; IPR036389; RNase_III_sf.
DR PANTHER; PTHR14950:SF62; DICER-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR14950; DICER-RELATED; 1.
DR Pfam; PF03368; Dicer_dimer; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00636; Ribonuclease_3; 2.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00535; RIBOc; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF69065; RNase III domain-like; 2.
DR PROSITE; PS51327; DICER_DSRBF; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS00517; RNASE_3_1; 1.
DR PROSITE; PS50142; RNASE_3_2; 2.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Antiviral protein {ECO:0000256|ARBA:ARBA00022721};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007115};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00657}.
FT DOMAIN 1..154
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 275..444
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 477..568
FT /note="Dicer dsRNA-binding fold"
FT /evidence="ECO:0000259|PROSITE:PS51327"
FT DOMAIN 884..1024
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT DOMAIN 1074..1246
FT /note="RNase III"
FT /evidence="ECO:0000259|PROSITE:PS50142"
FT NON_TER 1373
FT /evidence="ECO:0000313|EMBL:EHK20713.1"
SQ SEQUENCE 1373 AA; 153857 MW; EEED572D4A410E57 CRC64;
MRHVLQTELE NRAEGSEHKI AFFLVEKVAL CFQQHAVLTT NLEFPIGKFF GEMTGVVRSQ
EYWDRQFAEN MAFVCTAQIL LDLLACGFIS MGQINLMVFD EAHHAKKSHP YARIIKDHYL
RSRDERPRIL GMTASPVDAL TKDVRYAAAE LESMLCSKIA TISDEALMQN PEFSKTRLCD
LISRCVRSNP QFRRHLEFAA SASSILGTWC ADRYWQLLTT DNEMLRIEAR TGRDNLELDV
SAGDEAMAAI AKVKGIIRDH VFGPIQAGSP ELSSKVKTLY EVLEDAFCKR QAKRCIVFVE
ARSTAFLLAD LFQQPGMEIP GMKAAYMIGS HTSTASAAYM SYRDQIMSLQ KFRYGETNCL
FATSVAEEGI DIPECDVIIR FDLYTSAIQY IQSKGRARQK SSLYVSMMEE GNLEHMRKLR
RATRDAHALR QFCSALPEDR KVPDFVIGPD VLAAQEQVTQ KRYTVAGTGA QLTFITSLEV
LAKYASSFPN NAIDGLLPLE YIVTSIGKKF VARVILPDAS PIKMFPGEVQ KSKQLARCSA
AFEACVHLIG KKYINGNLQP AFTKKLPDMR NARLALSSDK KSEYDMRIKP DFWSSCLAPE
PPTSLYQTII ALDQPEALGR ASRPLILLTR KPLPDIPSTP LFFGGGQTSI MRLSNSQTSF
EVLPHEIEAL ASFTLRLFAD VFSKEYDAKS HEIPYFVAPS KLSPSRGDDA EIDWEAVQYA
HDNEQLRWEN APSEFFKDKL ATDPWDGSRK FILHGINAEL KPSDPTPKGV PQPKSLGYRK
VEQNIKEYSN SLSIKSRQRR NWRNDQPVVN AELLPIRRNF LDEFFVDDEC DGTCYVILEP
LRVSPIPVDV VSIALVLPVV IYRVDSVLIA LETCSLFDLA ICSDLALEAV TKDSFNTEEH
GEHQIDFQPG MGKNYERLEF LGDTFLKMAT TISVYTIAPD ADEFHYHVGR MMMLCNKNLF
EHAVEKGMPA YIRTKAFDRR TWYPSNMTLK RGKAARTETK HCLSHKSIAD VCEALIGAAY
MTSTTENMDM AVKAVTAMVC SEHHTMLEYK DYFATFQVPK WHGNHVSAAQ RLTVDKVAEI
TGYRFQCAPL ARSAFRHPSY VFETNIPDYQ QLEFLGDGLL DMAVVDFLFK RFPEADPKWL
TEHKTAMVSN QFLGCLCVKL GLHKHILLAT SALLGDIGRY ATQLEQAEEI ARQKSQGGDL
GYTSGGCFQA GAQPTPQDFW IEVPQPPKAL ADVVEALVGA MFVDSGYSFS VVLNFFTKFI
QPFFEDMALY SSFASNHPVT ALAHRLQTDF CCTQWRLHVA NVPVPMEAGY AVMSDNELLC
ALMVHGKVIA HATSSKSGMA AKVAVAKLAL EKLALIQDAA HFRGEMECDC SGG
//
