ID G9N2L2_HYPVG Unreviewed; 1208 AA.
AC G9N2L2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=TRIVIDRAFT_81241 {ECO:0000313|EMBL:EHK19322.1};
OS Hypocrea virens (strain Gv29-8 / FGSC 10586) (Gliocladium virens)
OS (Trichoderma virens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=413071 {ECO:0000313|EMBL:EHK19322.1, ECO:0000313|Proteomes:UP000007115};
RN [1] {ECO:0000313|EMBL:EHK19322.1, ECO:0000313|Proteomes:UP000007115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Gv29-8 / FGSC 10586 {ECO:0000313|Proteomes:UP000007115};
RX PubMed=21501500; DOI=10.1186/gb-2011-12-4-r40;
RA Kubicek C.P., Herrera-Estrella A., Seidl-Seiboth V., Martinez D.A.,
RA Druzhinina I.S., Thon M., Zeilinger S., Casas-Flores S., Horwitz B.A.,
RA Mukherjee P.K., Mukherjee M., Kredics L., Alcaraz L.D., Aerts A., Antal Z.,
RA Atanasova L., Cervantes-Badillo M.G., Challacombe J., Chertkov O.,
RA McCluskey K., Coulpier F., Deshpande N., von Doehren H., Ebbole D.J.,
RA Esquivel-Naranjo E.U., Fekete E., Flipphi M., Glaser F.,
RA Gomez-Rodriguez E.Y., Gruber S., Han C., Henrissat B., Hermosa R.,
RA Hernandez-Onate M., Karaffa L., Kosti I., Le Crom S., Lindquist E.,
RA Lucas S., Luebeck M., Luebeck P.S., Margeot A., Metz B., Misra M.,
RA Nevalainen H., Omann M., Packer N., Perrone G., Uresti-Rivera E.E.,
RA Salamov A., Schmoll M., Seiboth B., Shapiro H., Sukno S.,
RA Tamayo-Ramos J.A., Tisch D., Wiest A., Wilkinson H.H., Zhang M.,
RA Coutinho P.M., Kenerley C.M., Monte E., Baker S.E., Grigoriev I.V.;
RT "Comparative genome sequence analysis underscores mycoparasitism as the
RT ancestral life style of Trichoderma.";
RL Genome Biol. 12:R40.1-R40.15(2011).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK19322.1}.
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DR EMBL; ABDF02000084; EHK19322.1; -; Genomic_DNA.
DR RefSeq; XP_013953519.1; XM_014098044.1.
DR AlphaFoldDB; G9N2L2; -.
DR STRING; 413071.G9N2L2; -.
DR EnsemblFungi; EHK19322; EHK19322; TRIVIDRAFT_81241.
DR GeneID; 25798242; -.
DR VEuPathDB; FungiDB:TRIVIDRAFT_81241; -.
DR eggNOG; KOG0217; Eukaryota.
DR HOGENOM; CLU_002472_1_0_1; -.
DR InParanoid; G9N2L2; -.
DR OMA; TPMMAQY; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000007115; Unassembled WGS sequence.
DR GO; GO:0032301; C:MutSalpha complex; IEA:EnsemblFungi.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:EnsemblFungi.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0000400; F:four-way junction DNA binding; IEA:EnsemblFungi.
DR GO; GO:0032137; F:guanine/thymine mispair binding; IEA:EnsemblFungi.
DR GO; GO:0032138; F:single base insertion or deletion binding; IEA:EnsemblFungi.
DR GO; GO:0036297; P:interstrand cross-link repair; IEA:EnsemblFungi.
DR GO; GO:0043570; P:maintenance of DNA repeat elements; IEA:EnsemblFungi.
DR GO; GO:0000710; P:meiotic mismatch repair; IEA:EnsemblFungi.
DR GO; GO:0043111; P:replication fork arrest; IEA:EnsemblFungi.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677, ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000007115}.
FT DOMAIN 1046..1062
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 789..820
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 23..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..125
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..192
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1208 AA; 135144 MW; 9108FEBA3E475BD8 CRC64;
MPSDKPAASA ARTPAKATRP AAAAPSSTKQ KSIMSFFQKS SPVSASSAAR EKVSSANQHS
SPLKETKANS LPKTKSSAKF STPVPSSDAP EPASSQENME STVKRSKGKA SASLKDEESE
VAPSSPIRKG KKAINYAESS DEDEPFAYGA ASQSRRRGRA ARNIVNDEDD YGESDTAEQE
EEDDMDDFIV SDESDGETSR SRKRKRPSKP QSARKRTNLS SSPKRDAEQN MTSLDDDIDM
EDIPAASTAK QWSYDPDSTE KQPVVKPTER VATKDPKVKE KAYMKEPDER YTWLANIRDK
EKRSPTDPDY DPRTLYIPPI AWNKFSPFEK QYWEIKQDLW DTIVFFKKGK FYELYEKDAT
IGHQEFDFKM TDRVNMRMVG VPEGSLDHWV NQFIAKQYKV ARVEQMETNL GKEMRERQDK
TKKADKVISR KLGCILTAGT LVDGSMLQDD MAAYCVSIKE SVVDDLPAFG IAFTDTATGR
FFLSGFVDDI DRTKFETLVA QIGPRELLLE KSGLSTKSLR ILKNNTSPTT IWTNLKPGTE
FWDADTTRRE LDCAKYFVRE EDGEDIWPEA LKELKDDDLV MSAIGGLVSY LRFLKLEGPL
LSQGNFEVYN PIQKNSTLVL DGQTLTNLEL FANTVNGNSD GTLFGLLNKC ITPFGKRLFR
QWVAHPLCNI DRINERLDAV ELLNDDPSVR EQFASQLVKM PDLERLISRI HAGACKPEDF
VRVLEGFEQI EYTMTLVGAF KGGNGLIDRL ITSMPNLEEP LAYWSTAFDR QKAKEEKLMI
PESGVDEDFD ASVARIEEVK NQLNDLLAEK KAELKCKTLK FTDIGKEIYQ IEAPKSVKIP
SSWRQMSATK DVKRWYFTEL TGLVRELQEA EETHSQLIRE VASRFCKKFD VDYETWLKAI
KIIAQLDCLV SLAKASMSLG EPSCRPQFVD EERSVLEFEE LRHPCMINTV DDFIPNDIKL
GGDQAKINLL TGANAAGKST VLRMSCIAVI MAQVGCFVPA KSARLTPVDR IMSRLGANDN
IFAAQSTFFV ELSETKKILS EATPRSLVIL DELGRGTSSY DGVAVAQAVL HHVATHIGCI
GFFATHYHSL ATEFENHPEI RARRMQIHVD DEERRITFLY KLEDGVAEGS FGMHCAAMCG
ISDRVIKRAE IAAKEWEHTS RLKDSLDKAK TGCYIPLGIL SDVGSLLGNK GDVGAKGVEV
LLKAIESL
//
