ID G9N3I3_HYPVG Unreviewed; 876 AA.
AC G9N3I3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
GN ORFNames=TRIVIDRAFT_76275 {ECO:0000313|EMBL:EHK18867.1};
OS Hypocrea virens (strain Gv29-8 / FGSC 10586) (Gliocladium virens)
OS (Trichoderma virens).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=413071 {ECO:0000313|EMBL:EHK18867.1, ECO:0000313|Proteomes:UP000007115};
RN [1] {ECO:0000313|EMBL:EHK18867.1, ECO:0000313|Proteomes:UP000007115}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Gv29-8 / FGSC 10586 {ECO:0000313|Proteomes:UP000007115};
RX PubMed=21501500; DOI=10.1186/gb-2011-12-4-r40;
RA Kubicek C.P., Herrera-Estrella A., Seidl-Seiboth V., Martinez D.A.,
RA Druzhinina I.S., Thon M., Zeilinger S., Casas-Flores S., Horwitz B.A.,
RA Mukherjee P.K., Mukherjee M., Kredics L., Alcaraz L.D., Aerts A., Antal Z.,
RA Atanasova L., Cervantes-Badillo M.G., Challacombe J., Chertkov O.,
RA McCluskey K., Coulpier F., Deshpande N., von Doehren H., Ebbole D.J.,
RA Esquivel-Naranjo E.U., Fekete E., Flipphi M., Glaser F.,
RA Gomez-Rodriguez E.Y., Gruber S., Han C., Henrissat B., Hermosa R.,
RA Hernandez-Onate M., Karaffa L., Kosti I., Le Crom S., Lindquist E.,
RA Lucas S., Luebeck M., Luebeck P.S., Margeot A., Metz B., Misra M.,
RA Nevalainen H., Omann M., Packer N., Perrone G., Uresti-Rivera E.E.,
RA Salamov A., Schmoll M., Seiboth B., Shapiro H., Sukno S.,
RA Tamayo-Ramos J.A., Tisch D., Wiest A., Wilkinson H.H., Zhang M.,
RA Coutinho P.M., Kenerley C.M., Monte E., Baker S.E., Grigoriev I.V.;
RT "Comparative genome sequence analysis underscores mycoparasitism as the
RT ancestral life style of Trichoderma.";
RL Genome Biol. 12:R40.1-R40.15(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the importin beta family. Importin beta-1
CC subfamily. {ECO:0000256|ARBA:ARBA00010907}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK18867.1}.
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DR EMBL; ABDF02000085; EHK18867.1; -; Genomic_DNA.
DR RefSeq; XP_013953064.1; XM_014097589.1.
DR AlphaFoldDB; G9N3I3; -.
DR STRING; 413071.G9N3I3; -.
DR EnsemblFungi; EHK18867; EHK18867; TRIVIDRAFT_76275.
DR GeneID; 25797818; -.
DR VEuPathDB; FungiDB:TRIVIDRAFT_76275; -.
DR eggNOG; KOG1241; Eukaryota.
DR HOGENOM; CLU_008296_1_0_1; -.
DR InParanoid; G9N3I3; -.
DR OMA; QQYQERW; -.
DR OrthoDB; 124901at2759; -.
DR Proteomes; UP000007115; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR GO; GO:1990023; C:mitotic spindle midzone; IEA:EnsemblFungi.
DR GO; GO:0042564; C:NLS-dependent protein nuclear import complex; IEA:EnsemblFungi.
DR GO; GO:0005635; C:nuclear envelope; IEA:EnsemblFungi.
DR GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR GO; GO:0097718; F:disordered domain specific binding; IEA:EnsemblFungi.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:EnsemblFungi.
DR GO; GO:0061676; F:importin-alpha family protein binding; IEA:EnsemblFungi.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:EnsemblFungi.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:EnsemblFungi.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006607; P:NLS-bearing protein import into nucleus; IEA:EnsemblFungi.
DR GO; GO:0051292; P:nuclear pore complex assembly; IEA:EnsemblFungi.
DR GO; GO:0006656; P:phosphatidylcholine biosynthetic process; IEA:EnsemblFungi.
DR GO; GO:0006612; P:protein targeting to membrane; IEA:EnsemblFungi.
DR GO; GO:0046822; P:regulation of nucleocytoplasmic transport; IEA:EnsemblFungi.
DR GO; GO:0060188; P:regulation of protein desumoylation; IEA:EnsemblFungi.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF1; IMPORTIN SUBUNIT BETA-1; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007115}.
FT DOMAIN 24..105
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REPEAT 413..451
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 876 AA; 95903 MW; 5191DA84E3E800A5 CRC64;
MSSSEINTVL ANSLSPDANL RNAAEQQLTQ AAESNFPLYL ATLVQELANE QAESSIRAAA
GIALKNAFTA RDFARQQELQ TKWLQGTDDE TKNRVKQLTL QTLSSSNARA GNAAAQVISS
IAAIELPRNQ WPDLLSFLVK NVSEGADHQK QASLTTIGYI CESQDSELRL ALVTHSNAIL
TAVVQGARKE EANVEVRLAA ITALGDSLEF VANNFKHEGE RNYIMQVVCE ATQADDSRIQ
QGAFGCLNRI MGLYYENMRF YMEKALFGLT ILGMKSEDED VAKLAVEFWS TVCEEEISIE
DDNSQVESSD QMRSFYNFAR VAANEVVPVL LTLLTKQDED ATDDEYNLSR AAYQCLQLYS
QAVNATIIAP VLSFVESNLR SDDWHNRDAA VSAFGAIMEG PDEKVLEPIV KQALPVLITM
MDDSSLQVKD STAYALGRVT EACSEAIDAQ QHLPTLIASL FKGLISNAKM APSCCWALMN
LAERFAGDFG AASNPITPHF NQAVSSLLDV TARQDTETSV RTAAYEVLNV FVQNSASESL
PAVASLSDVI IKRLEETIPL QTQVVSVEDK LTLEEMQNSL CTVLQAIISR LDKEISPQGD
RIMQVLLQIL STIGGKSSVP EAVFATISAL STTMEEDFIK YMEAFVPFLY NALGNQDEPS
LCSMAIGLVS DITRSMGERS QPFCDNFMNY LLNNLRSTTL ANQFKPAILQ CFGDIAGAIG
GHFETYLSVV AQVLEQASTV TATPEGPDEM YYYVISLREG IMDAWGGIIG AMKSSGKTQV
LQQYVAAIFQ LLNLIGSDAN RSESLMRAAM GVIGDLADAY PNGELVDAFR QGWLTAMIKE
TKTNRDFQPR TIETARWARE QVKRQLGGTQ GVIAQS
//
