ID G9NSD0_HYPAI Unreviewed; 796 AA.
AC G9NSD0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Ras GEF {ECO:0008006|Google:ProtNLM};
GN ORFNames=TRIATDRAFT_240198 {ECO:0000313|EMBL:EHK46331.1};
OS Hypocrea atroviridis (strain ATCC 20476 / IMI 206040) (Trichoderma
OS atroviride).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=452589 {ECO:0000313|EMBL:EHK46331.1, ECO:0000313|Proteomes:UP000005426};
RN [1] {ECO:0000313|EMBL:EHK46331.1, ECO:0000313|Proteomes:UP000005426}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20476 / IMI 206040 {ECO:0000313|Proteomes:UP000005426};
RX PubMed=21501500; DOI=10.1186/gb-2011-12-4-r40;
RA Kubicek C.P., Herrera-Estrella A., Seidl-Seiboth V., Martinez D.A.,
RA Druzhinina I.S., Thon M., Zeilinger S., Casas-Flores S., Horwitz B.A.,
RA Mukherjee P.K., Mukherjee M., Kredics L., Alcaraz L.D., Aerts A., Antal Z.,
RA Atanasova L., Cervantes-Badillo M.G., Challacombe J., Chertkov O.,
RA McCluskey K., Coulpier F., Deshpande N., von Doehren H., Ebbole D.J.,
RA Esquivel-Naranjo E.U., Fekete E., Flipphi M., Glaser F.,
RA Gomez-Rodriguez E.Y., Gruber S., Han C., Henrissat B., Hermosa R.,
RA Hernandez-Onate M., Karaffa L., Kosti I., Le Crom S., Lindquist E.,
RA Lucas S., Luebeck M., Luebeck P.S., Margeot A., Metz B., Misra M.,
RA Nevalainen H., Omann M., Packer N., Perrone G., Uresti-Rivera E.E.,
RA Salamov A., Schmoll M., Seiboth B., Shapiro H., Sukno S.,
RA Tamayo-Ramos J.A., Tisch D., Wiest A., Wilkinson H.H., Zhang M.,
RA Coutinho P.M., Kenerley C.M., Monte E., Baker S.E., Grigoriev I.V.;
RT "Comparative genome sequence analysis underscores mycoparasitism as the
RT ancestral life style of Trichoderma.";
RL Genome Biol. 12:R40.1-R40.15(2011).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK46331.1}.
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DR EMBL; ABDG02000022; EHK46331.1; -; Genomic_DNA.
DR RefSeq; XP_013944563.1; XM_014089088.1.
DR AlphaFoldDB; G9NSD0; -.
DR STRING; 452589.G9NSD0; -.
DR GeneID; 25778456; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_005431_1_0_1; -.
DR OMA; HIAKWVA; -.
DR OrthoDB; 4819765at2759; -.
DR Proteomes; UP000005426; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000005426}.
FT DOMAIN 315..445
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 541..779
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 193..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..221
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 796 AA; 89284 MW; AB1D35427D8624AF CRC64;
MESYNIAIIG AMGVGKSTFV QRILGLSRPP ISTASSVRIN LDSTSYMITL LELDLDSFEL
NTNTPHPIQW PKQINGHIVP RVDAALVLYD VTNRDTIREL PQTLAALMNS NMPAVLVASK
CEAPEEEQEV NADELANHTL FKPVLAHYKI SSTSPDIDRS CLHAILRAAV AHRRGMSPQI
EIGEMVAARK RAQSAANLDA PDTSSRPVSQ GRHNRASSDF SLLRGFQAPG SGTPGADGHL
QKPASRSPHR DGTIYEIPDP GKLTATSTSL SFNGSCYARG SDAFLDVDES DTDSRRYSDD
IPILQRNDDV VIEKQQKKMT GLSFDDLVDR LLALRLSRAD ANFTDVFLCL YRKFAAPGKL
FSAILMRLDR VRDDKTTHHL TKTATQLRII ETMAKWVSTY PGDFARLTTR RNLDEFIRYL
STEPIFCIAA RQMHRNLTLH VIEDDDTGWA NADDANDQLA SDILSKELSE LPAGLTALQF
EEDGNFERPS VSSENLNRVV GSGGQIQLYS YEDYEREAST LDPTAQLPMN KFRYRIFVEI
KDDDIADELT RIDWIMFSSI RIRDFVRHVS LPASQKESCK SLNNINRMIN HFNHVARWVA
NMILLRDKAK HRAVVLEKFM NIALKLRQLN NYNGLAAVLA GLNGTAIHRL AQTKVLVSPD
THKKFARLLI LMGTQKSHFA YRLAWENSPL PRIPFIPLHR RDLVSAEEGS KTLVGPNGDR
INWKKFEVLG EVLLPLMKSQ GTPYPNLSKN DNVRELILSC HMTTDDEEIY QRSIVVESSS
SGGPLEPTKK IFPWLK
//
