ID G9P0Y9_HYPAI Unreviewed; 658 AA.
AC G9P0Y9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Manganese lipoxygenase {ECO:0000256|ARBA:ARBA00021175};
DE EC=1.13.11.45 {ECO:0000256|ARBA:ARBA00013178};
GN ORFNames=TRIATDRAFT_33350 {ECO:0000313|EMBL:EHK43236.1};
OS Hypocrea atroviridis (strain ATCC 20476 / IMI 206040) (Trichoderma
OS atroviride).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=452589 {ECO:0000313|EMBL:EHK43236.1, ECO:0000313|Proteomes:UP000005426};
RN [1] {ECO:0000313|EMBL:EHK43236.1, ECO:0000313|Proteomes:UP000005426}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20476 / IMI 206040 {ECO:0000313|Proteomes:UP000005426};
RX PubMed=21501500; DOI=10.1186/gb-2011-12-4-r40;
RA Kubicek C.P., Herrera-Estrella A., Seidl-Seiboth V., Martinez D.A.,
RA Druzhinina I.S., Thon M., Zeilinger S., Casas-Flores S., Horwitz B.A.,
RA Mukherjee P.K., Mukherjee M., Kredics L., Alcaraz L.D., Aerts A., Antal Z.,
RA Atanasova L., Cervantes-Badillo M.G., Challacombe J., Chertkov O.,
RA McCluskey K., Coulpier F., Deshpande N., von Doehren H., Ebbole D.J.,
RA Esquivel-Naranjo E.U., Fekete E., Flipphi M., Glaser F.,
RA Gomez-Rodriguez E.Y., Gruber S., Han C., Henrissat B., Hermosa R.,
RA Hernandez-Onate M., Karaffa L., Kosti I., Le Crom S., Lindquist E.,
RA Lucas S., Luebeck M., Luebeck P.S., Margeot A., Metz B., Misra M.,
RA Nevalainen H., Omann M., Packer N., Perrone G., Uresti-Rivera E.E.,
RA Salamov A., Schmoll M., Seiboth B., Shapiro H., Sukno S.,
RA Tamayo-Ramos J.A., Tisch D., Wiest A., Wilkinson H.H., Zhang M.,
RA Coutinho P.M., Kenerley C.M., Monte E., Baker S.E., Grigoriev I.V.;
RT "Comparative genome sequence analysis underscores mycoparasitism as the
RT ancestral life style of Trichoderma.";
RL Genome Biol. 12:R40.1-R40.15(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy-(9Z,12Z)-
CC octadecadienoate; Xref=Rhea:RHEA:18993, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:30245, ChEBI:CHEBI:57467; EC=1.13.11.45;
CC Evidence={ECO:0000256|ARBA:ARBA00000366};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK43236.1}.
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DR EMBL; ABDG02000026; EHK43236.1; -; Genomic_DNA.
DR RefSeq; XP_013940576.1; XM_014085101.1.
DR AlphaFoldDB; G9P0Y9; -.
DR STRING; 452589.G9P0Y9; -.
DR GeneID; 25783855; -.
DR eggNOG; ENOG502QVKD; Eukaryota.
DR HOGENOM; CLU_009802_0_0_1; -.
DR OMA; FHNYAYA; -.
DR OrthoDB; 1050333at2759; -.
DR Proteomes; UP000005426; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0050584; F:linoleate 11-lipoxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043651; P:linoleic acid metabolic process; IEA:UniProt.
DR GO; GO:0034440; P:lipid oxidation; IEA:InterPro.
DR Gene3D; 3.10.450.60; -; 1.
DR InterPro; IPR000907; LipOase.
DR InterPro; IPR013819; LipOase_C.
DR InterPro; IPR036226; LipOase_C_sf.
DR PANTHER; PTHR11771; LIPOXYGENASE; 1.
DR PANTHER; PTHR11771:SF153; LIPOXYGENASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00305; Lipoxygenase; 1.
DR SUPFAM; SSF48484; Lipoxigenase; 1.
DR PROSITE; PS51393; LIPOXYGENASE_3; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000005426};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 162..658
FT /note="Lipoxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51393"
SQ SEQUENCE 658 AA; 75028 MW; D0AB3F29687A5849 CRC64;
MEQILALVTQ LYGRVERSYN AYLDVVEVEP TWPRLLNLDQ TSEMFEWATQ VPDGKGGFME
YPPHLKVIPN EDDVGLLKIF DKLGLLETQW IISPFIPDSW WGDIIEKGAE WVIKRIRQKT
GDVTAWANQD PNFKALESYN ESHRKTATDV SEGRNLGLLG DWYSDRRFAE QAFTGTNPTT
LVNIAKTPGN LLQEFIDAAE RLGYKEWHQK LTKAQSKPES LFVQDHRYFR EAFGAAPDEE
LKHQELGAEL NWACAAVTLF ELHEDGRLHP AAIVIDYKVS MKDSVTIFNN RLEPRDPVGG
GAAIPEEESD WPWRYAKSCA QVSDWMRHEV GVHLTRAHFI EEAVIVATRR TIRMDSIIHT
ILAPHWYKTL SLNASARTIL VPQVIKDLVG ISPEYLQKYV LYEFENFDFV KHYVPNDLEE
RGFPNTAEGL AAPKYKNYAY AKNMVSMWAV IRKYVSAMLL TTYKQETADA EISNDTHIQN
WVKELRTNGR IKSFPDIKTL DALTDALTMC IHIAAPFHTA VNYLQNFYQA FVPAKPPAVC
QKLPASLEEL KSYTEPELIN ALPIGRERQW LLAVQVPWLL SFKVADERSL IKFAYSQSRN
YRSGFGKKAR AIRTISGQLH DDLNKLGPEF VLTSQGMDKG SIPYMVLDPN VTAVSILI
//
