ID G9P1B2_HYPAI Unreviewed; 1759 AA.
AC G9P1B2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00012494};
DE EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494};
GN ORFNames=TRIATDRAFT_294361 {ECO:0000313|EMBL:EHK43300.1};
OS Hypocrea atroviridis (strain ATCC 20476 / IMI 206040) (Trichoderma
OS atroviride).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=452589 {ECO:0000313|EMBL:EHK43300.1, ECO:0000313|Proteomes:UP000005426};
RN [1] {ECO:0000313|EMBL:EHK43300.1, ECO:0000313|Proteomes:UP000005426}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 20476 / IMI 206040 {ECO:0000313|Proteomes:UP000005426};
RX PubMed=21501500; DOI=10.1186/gb-2011-12-4-r40;
RA Kubicek C.P., Herrera-Estrella A., Seidl-Seiboth V., Martinez D.A.,
RA Druzhinina I.S., Thon M., Zeilinger S., Casas-Flores S., Horwitz B.A.,
RA Mukherjee P.K., Mukherjee M., Kredics L., Alcaraz L.D., Aerts A., Antal Z.,
RA Atanasova L., Cervantes-Badillo M.G., Challacombe J., Chertkov O.,
RA McCluskey K., Coulpier F., Deshpande N., von Doehren H., Ebbole D.J.,
RA Esquivel-Naranjo E.U., Fekete E., Flipphi M., Glaser F.,
RA Gomez-Rodriguez E.Y., Gruber S., Han C., Henrissat B., Hermosa R.,
RA Hernandez-Onate M., Karaffa L., Kosti I., Le Crom S., Lindquist E.,
RA Lucas S., Luebeck M., Luebeck P.S., Margeot A., Metz B., Misra M.,
RA Nevalainen H., Omann M., Packer N., Perrone G., Uresti-Rivera E.E.,
RA Salamov A., Schmoll M., Seiboth B., Shapiro H., Sukno S.,
RA Tamayo-Ramos J.A., Tisch D., Wiest A., Wilkinson H.H., Zhang M.,
RA Coutinho P.M., Kenerley C.M., Monte E., Baker S.E., Grigoriev I.V.;
RT "Comparative genome sequence analysis underscores mycoparasitism as the
RT ancestral life style of Trichoderma.";
RL Genome Biol. 12:R40.1-R40.15(2011).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517};
CC -!- SIMILARITY: Belongs to the RdRP family.
CC {ECO:0000256|ARBA:ARBA00005762}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK43300.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ABDG02000026; EHK43300.1; -; Genomic_DNA.
DR RefSeq; XP_013941507.1; XM_014086032.1.
DR STRING; 452589.G9P1B2; -.
DR GeneID; 25780386; -.
DR eggNOG; KOG0988; Eukaryota.
DR eggNOG; KOG1802; Eukaryota.
DR HOGENOM; CLU_002184_0_0_1; -.
DR OMA; YVISNRD; -.
DR OrthoDB; 2905532at2759; -.
DR Proteomes; UP000005426; Unassembled WGS sequence.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR CDD; cd18808; SF1_C_Upf1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041679; DNA2/NAM7-like_C.
DR InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR InterPro; IPR047187; SF1_C_Upf1.
DR PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR PANTHER; PTHR23079:SF55; RNA-DIRECTED RNA POLYMERASE; 1.
DR Pfam; PF13086; AAA_11; 1.
DR Pfam; PF13087; AAA_12; 1.
DR Pfam; PF13604; AAA_30; 1.
DR Pfam; PF05183; RdRP; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022484};
KW Reference proteome {ECO:0000313|Proteomes:UP000005426};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1327..1470
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 838..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 842..857
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1759 AA; 196663 MW; 780200A5BFC5EACD CRC64;
MPPASASPKS FEHVLLDNIS LDDQKWEFNV PRLPTADSAN KLNYIKMVSL STKDSRHRLE
LRYGPVDMNR AIQDVSLDKY LVVSLAEFRS IKNPNSPSTV EGDTSKVIQP TTYRECSEYA
VKFLRTGISI QGVHYNFYGH SNSQLKSRTC YFLAAPKEQI SKKIEGLGDF TKMKTVAKKA
KRIGLLFSVA RAAMKVDPKK VEDIPDIEVG DYVFTDGCGL IAPALAKELS RRTRIIFRNM
RYTPSVFQLR YRGYKGVVTL DPTMAKGGTW LKMRKSMKKF SGGDDLSFSV VEYSKPYVFG
HLNDEVIVLL DALGVDRKIL LRKQQEHFNF LAEAYQDPRA AFRVLCHLDR PDLAERVIID
SLDSVRPSIN RLINAEYDKM LNKRDEQKCR ILIPKSRLLF GVCDAWGVLK PGQCAVKVTM
DVDGLPYALK GTKVLVTRNP CLHPGDLQKL DVVERPELAH LVDCIVFPTT GRRPAADMMS
GGDLDGDTFF VTWDPDIIPS TISQAAHYPG VREPLRFAPI TDDDRLLYFA KYTNASLGRV
KNLYLRWARA TNAMRPECQE LNRLFSQCVD GNRIKDSQLD KFAKPPEPDA EAPPFVLDEL
HDAAKNIIAR QKLEARSRTD SLEGYTLDAI QLLLCRDDIA ISEAELIRMA VRWCRKTNTP
FYHLLHMFDL NSLKSEDKAW VLAQMPTYVD APSFVLNALC SSSLLTEAEL KHFHLDYPGM
HWKRVYTTEQ DRPATFMEAT CRNLELFHKK MIIFRPNERL TVAMYVPQKI TPADDFVVGS
KVRLFAFPHS QGRETQSRLS LPTKKEYRLY CDPTTLQLFE GRRGNTWIYI GRGGSNDSTY
RNAPTEKDRR KARQDSVDNG TNFDFRASIA LDKFSKNLQG HIGRLHRQGI SDAEIYIISN
RDFSSMRSLD LWEDYIDTEQ TLPLFPHEPK EYDVPKLQDV DWSLGAQPPL VVEVVKRGNI
SALQDVLDAS TLRQLFLWLV EQEQRGLLIR CFDHLITSIR SDKVMAPADT LRTMVEFTET
MPYVSATFAN LGSWKDLPEA LDTILQNESY ILLRSIILSE AEFGDLILVP FHTILENVEF
LTLRSFSDLF ELIALTVHSP STALDLLLEG LDQQSSRLLT GRPAITQHFV HNVIGIAVEH
IGAVKEEAKA RDELLSIQII SDDEKTSKGG YGTRVQVSFR IDAPGGSPLA NTHVRLVAAS
PPSSSILDET YSMDGLVVES RSGMAKINCL HPPPSYAEKC SWILEECGLF VTAKTMLDAV
RELGISEDGC CGVIDQIMGI QPQHVVNPRA AHEGRADTDT LMPGLTLSEA DASLNTSQRS
AVEAAQRNKL VCLWGPPGTG KTQTIVAIIR RLQQDAKTER ILVTAPTHNA VDNVMRRYLT
RISKEGLAPN SPETAPLRVS TEVRKVGEDL RKYTCDALAG QEIHSSHAAQ RQAKQRVKAA
TIIFTTCIGA GLGLLRGQMF DTVIVDEASQ QTEPASLVPL VKGCEKAILV GDHVQLRPTV
QEFSPALGFD VSLFERLYTR QGTTPGMAKI MLDTQYRMHP SICGFISKEF YEKRLLSGLK
DSDRPMSPSA FPWPASSTTT ISSSSASRML FVECSGREDL GHKSKSNKEQ ADVCLSICKL
LRSAPAAPAS SAENHINGAK PADVMNNDTT TSIAVLTPYS RQSEILKKLL SAIPNAEVSS
IDGFQGREAD IVIFVTVRCN ESREIGFLKD LRRMNVALTR AKLGLIIVGN RATLTGGSEE
EESTGVWRRL MGQLSNVAL
//
