ID G9PDE0_9ACTO Unreviewed; 609 AA.
AC G9PDE0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Cation/H+ exchanger domain-containing protein {ECO:0000259|Pfam:PF00999};
GN ORFNames=HMPREF0045_00023 {ECO:0000313|EMBL:EHM89358.1};
OS Actinomyces graevenitzii C83.
OC Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC Actinomyces.
OX NCBI_TaxID=435830 {ECO:0000313|EMBL:EHM89358.1, ECO:0000313|Proteomes:UP000003822};
RN [1] {ECO:0000313|EMBL:EHM89358.1, ECO:0000313|Proteomes:UP000003822}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C83 {ECO:0000313|EMBL:EHM89358.1,
RC ECO:0000313|Proteomes:UP000003822};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Earl A., Ward D., Feldgarden M., Gevers D., Sibley C.D., Field T.R.,
RA Grinwis M., Eshaghurshan C.S., Surette M.G., Young S.K., Zeng Q.,
RA Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C.,
RA Freedman E., Gearin G., Goldberg J., Griggs A., Gujja S., Heiman D.,
RA Howarth C., Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N.,
RA Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Actinomyces graevenitzii C83.";
RL Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHM89358.1}.
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DR EMBL; ACRN01000001; EHM89358.1; -; Genomic_DNA.
DR AlphaFoldDB; G9PDE0; -.
DR STRING; 435830.HMPREF0045_00023; -.
DR PATRIC; fig|435830.3.peg.22; -.
DR eggNOG; COG0025; Bacteria.
DR HOGENOM; CLU_005912_8_2_11; -.
DR OrthoDB; 57886at2; -.
DR Proteomes; UP000003822; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00999; Na_H_Exchanger; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000003822};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 30..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..335
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 404..465
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
SQ SEQUENCE 609 AA; 66667 MW; 27EAD0B71446B546 CRC64;
MTMTQTLIIA LSALAIIALS EPLSEKLRLA TPVILLVIGG ALSFLPQFAG FEVDPDLIIE
VILPPLLFAT AVNTPVQDFR RNLSAITSLA FLLVIASTVA LGFVLNAIIP GLGLPIGMAM
GAVMSPTDAV ATTIVKSQGV QRRIVTILEG EGLINDASAL VLLRSALGAV AGSVSLLSIT
QSLVWSVVGA LVVGMIVGHL TLWLRSHIGD ARAATILSFI VPFAASIPAE EMHSSGLVAA
VVAGLVTSYH HDNKLSPAQR MISNNSWQTF GLIFESLVFL LMGLQLNNIL SSFKDSGYEL
SLAFKAAIIS LLVVTIMRTL VVFATTYYAR FRARDLISKR AHLDSWELIL DEVDDGQLPE
GLPYGPQLPN LVRRRTPTSQ QRLERIRMRL DRRRADMQYY EEAHLGYREG LTMVWAGMRG
AITLAAAQTF PLSTPNRNFL MFTAFLVAAI SLIIQGGTLA AFIRWIKPDS AGGYAPDELD
AVYQLIEVAK ESVDMPEELT RIIGPCDSHT VAAKLRKWNA HRIEDPLVAL EVRILMCKYQ
LEVHRAEREA LVEQNRKGTI TSDVYRLTLK LIDGSEMRVE TQLNMAQGGM NRILEDEENS
LAEDNRSDD
//
