ID   G9PMG3_9ACTO            Unreviewed;       288 AA.
AC   G9PMG3;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=HIT domain-containing protein {ECO:0000259|PROSITE:PS51084};
GN   ORFNames=HMPREF0975_01584 {ECO:0000313|EMBL:EHM94284.1};
OS   Actinomyces sp. oral taxon 849 str. F0330.
OC   Bacteria; Actinomycetota; Actinomycetes; Actinomycetales; Actinomycetaceae;
OC   Actinomyces.
OX   NCBI_TaxID=653386 {ECO:0000313|EMBL:EHM94284.1, ECO:0000313|Proteomes:UP000003600};
RN   [1] {ECO:0000313|EMBL:EHM94284.1, ECO:0000313|Proteomes:UP000003600}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0330 {ECO:0000313|EMBL:EHM94284.1,
RC   ECO:0000313|Proteomes:UP000003600};
RG   The Broad Institute Genome Sequencing Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Izard J., Baranova O.V.,
RA   Blanton J.M., Tanner A.C., Dewhirst F.E., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E.,
RA   Gearin G., Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C.,
RA   Larson L., Lui A., MacDonald P.J.P., Montmayeur A., Murphy C., Neiman D.,
RA   Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA   Stolte C., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Actinomyces sp. oral taxon 849 str. F0330.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHM94284.1}.
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DR   EMBL; ACTB01000093; EHM94284.1; -; Genomic_DNA.
DR   AlphaFoldDB; G9PMG3; -.
DR   STRING; 653386.HMPREF0975_01584; -.
DR   PATRIC; fig|653386.3.peg.1461; -.
DR   eggNOG; COG0537; Bacteria.
DR   HOGENOM; CLU_965172_0_0_11; -.
DR   Proteomes; UP000003600; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   Gene3D; 3.30.428.10; HIT-like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR001310; Histidine_triad_HIT.
DR   InterPro; IPR011146; HIT-like.
DR   InterPro; IPR036265; HIT-like_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46648:SF1; ADENOSINE 5'-MONOPHOSPHORAMIDASE HNT1; 1.
DR   PANTHER; PTHR46648; HIT FAMILY PROTEIN 1; 1.
DR   Pfam; PF01230; HIT; 1.
DR   PRINTS; PR00332; HISTRIAD.
DR   SUPFAM; SSF54197; HIT-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51084; HIT_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000003600}.
FT   DOMAIN          144..247
FT                   /note="HIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51084"
FT   MOTIF           231..235
FT                   /note="Histidine triad motif"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601310-3,
FT                   ECO:0000256|PROSITE-ProRule:PRU00464"
FT   ACT_SITE        233
FT                   /note="Tele-AMP-histidine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601310-1"
SQ   SEQUENCE   288 AA;  30691 MW;  7CAA16A79F9A5D87 CRC64;
     MRIDAEQGGE LTSSSGGGEA NLSSIAVVRA TRNGVDETLA RLREAGLAAV KVDDRTSESA
     FPGGIRVMTM HRAKGLEYRA VAVRDASPRS GRARRHMADD RQILVCGSIS CTSPRLVPAS
     GYSSADEPGR IRARLGDNGA MSTIFTKIIK GEIPGRFVWA DEVCVAFATI EPHTDGHVLV
     VPRVEVDSYV DAPDDVVAHL AVVAKRIGAA QVRVFEAPRA GLVVAGYGVD HLHLHVLPIR
     SEEDLSFSSA RHPEGPELDA AMERLRGGLV EDGWGEFVPA RLDSAALA
//