ID   G9ZUF2_9PROT            Unreviewed;       653 AA.
AC   G9ZUF2;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   SubName: Full=Squalene-hopene cyclase {ECO:0000313|EMBL:EHM03396.1};
GN   ORFNames=HMPREF9946_00166 {ECO:0000313|EMBL:EHM03396.1};
OS   Acetobacteraceae bacterium AT-5844.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC   Acetobacteraceae.
OX   NCBI_TaxID=1054213 {ECO:0000313|EMBL:EHM03396.1, ECO:0000313|Proteomes:UP000003292};
RN   [1] {ECO:0000313|EMBL:EHM03396.1, ECO:0000313|Proteomes:UP000003292}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AT-5844 {ECO:0000313|Proteomes:UP000003292};
RA   Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA   Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA   Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA   Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA   Chinwalla A., Mardis E.R., Wilson R.K.;
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004999}.
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHM03396.1}.
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DR   EMBL; AGEZ01000011; EHM03396.1; -; Genomic_DNA.
DR   AlphaFoldDB; G9ZUF2; -.
DR   STRING; 1054213.HMPREF9946_00166; -.
DR   PATRIC; fig|1054213.3.peg.156; -.
DR   eggNOG; COG1657; Bacteria.
DR   HOGENOM; CLU_019345_0_0_5; -.
DR   OrthoDB; 9758578at2; -.
DR   BioCyc; ABAC1054213:G1H32-155-MONOMER; -.
DR   UniPathway; UPA00337; -.
DR   Proteomes; UP000003292; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   InterPro; IPR006400; Hopene-cyclase.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01507; hopene_cyclase; 1.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000003292};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          24..309
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          320..640
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
SQ   SEQUENCE   653 AA;  72503 MW;  1EC7363A6FC01ADC CRC64;
     MNDAFSFQAS PATPVSPDGV EDAIHHATAA LGRYQREDGH WVFELEADAT IPAEYVLLRH
     YLGEPDDLTL ERKIGNYLRR IQGAHGGWPL FHGGAFDISA SVKAYFCLKM IGDDPDAPHM
     VRAREAILAQ GGAARCNVFT RILLAQFGEL PWSAVPAMPV EMILLPRWFP VHLSKMSYWA
     RTVIVPLLVL QAVKRRARNP RGIGVQELFR PGVRVGTPLT HQRRGWAAFF NGLDVVLQKV
     EPLWPRGQRQ QAIARCEAFV TERLNGEDGL GAIYPAIANS VMMYDALGHG PEHPGRAIAR
     QAIEKLLVVG EDEAYCQPCV SPVWDTALAS HAMLEVGGEA AGAALRGLEW LRPRQELEVK
     GDWAETRPDV RPGGWAFQYR NAHYPDLDDT AVVVMAMDRA RYQFGAGGGY DIAIDRGAEW
     VVGLQSTNGG WGAFDVDNNH DFLNNIPFAD HGALLDPPTA DVSARCVSML AQLGRTDTPE
     MRRALDYLER EQEKDGSWFG RWGVNYVYGT WSALCALNAA GFDATRPSMR RGADWLLSIQ
     NEDGGWGEDC DSYKLDYRGY EPAPSTASQT AWALLGLMAA GEVDNPAVAR GIEWLRRMQG
     EDGLWPQEAY TGGGFPRIFY LRYHGYPKFF PLWALARYRN LRAGNARHVS HGM
//