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Database: UniProt
Entry: GDX_YERPE
LinkDB: GDX_YERPE
Original site: GDX_YERPE 
ID   GDX_YERPE               Reviewed;         104 AA.
AC   Q8D1E4; Q0WJV5; Q74XC5; Q8ZIX9;
DT   04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 2.
DT   24-JAN-2024, entry version 116.
DE   RecName: Full=Guanidinium exporter {ECO:0000250|UniProtKB:P69937};
GN   Name=gdx {ECO:0000250|UniProtKB:P69937}; Synonyms=sugE;
GN   OrderedLocusNames=YPO0355, y0613, YP_0511;
OS   Yersinia pestis.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- FUNCTION: Guanidinium ion exporter. Couples guanidinium export to the
CC       proton motive force, exchanging one guanidinium ion for two protons.
CC       {ECO:0000250|UniProtKB:P69937}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000250|UniProtKB:P69937}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P69937}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.
CC       Gdx/SugE subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM84201.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAS60781.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL590842; CAL19037.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM84201.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017042; AAS60781.1; ALT_INIT; Genomic_DNA.
DR   PIR; AC0044; AC0044.
DR   RefSeq; WP_002228124.1; NZ_WUCM01000014.1.
DR   RefSeq; YP_002345433.1; NC_003143.1.
DR   AlphaFoldDB; Q8D1E4; -.
DR   SMR; Q8D1E4; -.
DR   STRING; 214092.YPO0355; -.
DR   PaxDb; 214092-YPO0355; -.
DR   DNASU; 1145560; -.
DR   EnsemblBacteria; AAS60781; AAS60781; YP_0511.
DR   GeneID; 66843177; -.
DR   KEGG; ype:YPO0355; -.
DR   KEGG; ypk:y0613; -.
DR   KEGG; ypm:YP_0511; -.
DR   PATRIC; fig|214092.21.peg.591; -.
DR   eggNOG; COG2076; Bacteria.
DR   HOGENOM; CLU_133067_1_2_6; -.
DR   OMA; FEIAWAI; -.
DR   OrthoDB; 9808638at2; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR   GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR   Gene3D; 1.10.3730.20; -; 1.
DR   InterPro; IPR000390; Small_drug/metabolite_transptr.
DR   InterPro; IPR045324; Small_multidrug_res.
DR   PANTHER; PTHR30561:SF0; GUANIDINIUM EXPORTER; 1.
DR   PANTHER; PTHR30561; SMR FAMILY PROTON-DEPENDENT DRUG EFFLUX TRANSPORTER SUGE; 1.
DR   Pfam; PF00893; Multi_Drug_Res; 1.
DR   SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Ion transport; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..104
FT                   /note="Guanidinium exporter"
FT                   /id="PRO_0000108108"
FT   TOPO_DOM        1
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        2..19
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        20..28
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        49..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..81
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        101..104
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   104 AA;  10651 MW;  6DADB41E0B97B5BB CRC64;
     MAWIILVIAG LLEVIWAIGL KYSHGFSRLT PSIITLVAMA ASVFLLAYAM KSLPAGTAYA
     VWTGIGAVGT AILGIVLLGE SASLARILSL GLILAGIIGL KLAS
//
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