ID GEP4_SCHPO Reviewed; 209 AA.
AC Q9Y7U3;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2012, sequence version 2.
DT 27-MAR-2024, entry version 116.
DE RecName: Full=Probable phosphatidylglycerophosphatase, mitochondrial;
DE EC=3.1.3.27;
DE AltName: Full=PGP phosphatase;
GN Name=gep4; ORFNames=SPCC645.02;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Phosphatidylglycerophosphatase involved in the biosynthesis
CC of cardiolipin (CL), a unique dimeric phosphoglycerolipid predominantly
CC present in mitochondrial membranes and which has important functions
CC for cellular energy metabolism, mitochondrial dynamics and the
CC initiation of apoptotic pathways. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) +
CC H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate;
CC Xref=Rhea:RHEA:33751, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:60110, ChEBI:CHEBI:64716; EC=3.1.3.27;
CC -!- PATHWAY: Phospholipid metabolism; phosphatidylglycerol biosynthesis;
CC phosphatidylglycerol from CDP-diacylglycerol: step 2/2.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:16823372}; Peripheral membrane protein
CC {ECO:0000269|PubMed:16823372}; Matrix side
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the GEP4 family. {ECO:0000305}.
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DR EMBL; CU329672; CAB39898.2; -; Genomic_DNA.
DR PIR; T41519; T41519.
DR RefSeq; NP_588111.2; NM_001023101.2.
DR AlphaFoldDB; Q9Y7U3; -.
DR STRING; 284812.Q9Y7U3; -.
DR MaxQB; Q9Y7U3; -.
DR PaxDb; 4896-SPCC645-02-1; -.
DR EnsemblFungi; SPCC645.02.1; SPCC645.02.1:pep; SPCC645.02.
DR GeneID; 2539038; -.
DR KEGG; spo:SPCC645.02; -.
DR PomBase; SPCC645.02; gep4.
DR VEuPathDB; FungiDB:SPCC645.02; -.
DR eggNOG; KOG2961; Eukaryota.
DR HOGENOM; CLU_056221_3_2_1; -.
DR InParanoid; Q9Y7U3; -.
DR OMA; WHEYTAK; -.
DR UniPathway; UPA00084; UER00504.
DR PRO; PR:Q9Y7U3; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005759; C:mitochondrial matrix; ISO:PomBase.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0008962; F:phosphatidylglycerophosphatase activity; IBA:GO_Central.
DR GO; GO:0032049; P:cardiolipin biosynthetic process; IBA:GO_Central.
DR GO; GO:0007006; P:mitochondrial membrane organization; IC:PomBase.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006549; HAD-SF_hydro_IIIA.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR027706; PGP_Pase.
DR NCBIfam; TIGR01662; HAD-SF-IIIA; 1.
DR Pfam; PF09419; PGP_phosphatase; 1.
DR SUPFAM; SSF56784; HAD-like; 2.
PE 3: Inferred from homology;
KW Hydrolase; Lipid biosynthesis; Lipid metabolism; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Phospholipid biosynthesis;
KW Phospholipid metabolism; Reference proteome.
FT CHAIN 1..209
FT /note="Probable phosphatidylglycerophosphatase,
FT mitochondrial"
FT /id="PRO_0000351427"
FT MOTIF 57..61
FT /note="Phosphoryl acceptor"
SQ SEQUENCE 209 AA; 23992 MW; DD99C64B73CF1043 CRC64;
MLINIEGIQA FCQTIRNPRR IIPHATFPTF SQIPCNINYF LEQKFQVPVD IRALVLDKDN
CITLPNETTI AEAELKKIRE FQNIYGEKNV ILLSNSIGTR KLDPTGELAA HFQQKWNIPV
VRHSKLKPLC TEELYTYLSN NSHVSSASQI LFIGDRLLTD ITLANIMGSW GVWLTRGVGN
TTNMMMEVES WLYKRIHTQN PYIPTNRKS
//
