ID GIMA6_BOVIN Reviewed; 341 AA.
AC A5PKB7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUL-2007, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=GTPase IMAP family member 6;
DE AltName: Full=Immunity-associated nucleotide 6 protein;
DE Short=IAN-6;
GN Name=GIMAP6; Synonyms=IAN6;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q6P9H5}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family.
CC IAN subfamily. {ECO:0000305}.
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DR EMBL; BC142429; AAI42430.1; -; mRNA.
DR RefSeq; NP_001093182.1; NM_001099712.1.
DR AlphaFoldDB; A5PKB7; -.
DR SMR; A5PKB7; -.
DR STRING; 9913.ENSBTAP00000068658; -.
DR GeneID; 528288; -.
DR CTD; 474344; -.
DR InParanoid; A5PKB7; -.
DR OrthoDB; 938643at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR CDD; cd01852; AIG1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR006703; G_AIG1.
DR InterPro; IPR045058; GIMA/IAN/Toc.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10903:SF144; GTPASE IMAP FAMILY MEMBER 6; 1.
DR PANTHER; PTHR10903; GTPASE, IMAP FAMILY MEMBER-RELATED; 1.
DR Pfam; PF04548; AIG1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51720; G_AIG1; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..341
FT /note="GTPase IMAP family member 6"
FT /id="PRO_0000333010"
FT DOMAIN 91..294
FT /note="AIG1-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 28..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 100..107
FT /note="G1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 127..131
FT /note="G2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 148..151
FT /note="G3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 217..220
FT /note="G4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT REGION 254..256
FT /note="G5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01057"
FT COMPBIAS 35..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 100..108
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q8WWP7"
FT BINDING 121
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q9UG22"
FT BINDING 218..220
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q8WWP7"
FT BINDING 255
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250|UniProtKB:Q8WWP7"
SQ SEQUENCE 341 AA; 37305 MW; 2BA34CC3391CBE75 CRC64;
MSSMFVYVWG TVTDLLHSAC SVLALNGDTE SSGEHTAPGD TRHGHSSCPT DSRAMEEEEF
EILLPEEPEE GTSQDPSPDR SGGFLGDEGT LQTLWLILVG KSGSGKSATG NSILGRRVFE
SKLSARPVTQ AFQQGCRAWE GRELQVIDTP DILSPWAAGW ATAQGVGEAG TGSLPKQYAV
LLVTQLGRFT EEDQQVAGRL EEVFGKGILA RTILVFTRKE DLDGRSLETY LRETDNRALA
KLDDVCSRRH CGFNNKGDGA EQETQLRELM RHVEGVLKEP EGCAYSPPAT PQPHAAPRES
WGLWWLGAKE GRGDQAWLWG LHRILKEPEQ AGRQLPPSTP I
//
