ID GIP_MOUSE Reviewed; 144 AA.
AC P48756; Q9D887;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 24-JAN-2024, entry version 138.
DE RecName: Full=Gastric inhibitory polypeptide;
DE Short=GIP;
DE AltName: Full=Glucose-dependent insulinotropic polypeptide;
DE Flags: Precursor;
GN Name=Gip;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8764827; DOI=10.1016/0167-4781(96)00103-0;
RA Schieldrop P.J., Gelling R.W., Elliot R., Hewitt J., Kieffer T.J.,
RA McIntosh C.H.S., Pederson R.A.;
RT "Isolation of a murine glucose-dependent insulinotropic polypeptide (GIP)
RT cDNA from a tumor cell line (STC6-14) and quantification of glucose-induced
RT increases in GIP mRNA.";
RL Biochim. Biophys. Acta 1308:111-113(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Small intestine;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potent stimulator of insulin secretion and relatively poor
CC inhibitor of gastric acid secretion.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR EMBL; U34295; AAC52731.1; -; mRNA.
DR EMBL; AK008308; BAB25592.1; -; mRNA.
DR EMBL; AL603682; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466556; EDL16005.1; -; Genomic_DNA.
DR CCDS; CCDS25287.1; -.
DR PIR; S71426; S71426.
DR RefSeq; NP_032145.2; NM_008119.2.
DR RefSeq; XP_006532287.1; XM_006532224.3.
DR RefSeq; XP_006532288.1; XM_006532225.3.
DR AlphaFoldDB; P48756; -.
DR SMR; P48756; -.
DR STRING; 10090.ENSMUSP00000099446; -.
DR PhosphoSitePlus; P48756; -.
DR PaxDb; 10090-ENSMUSP00000099446; -.
DR PeptideAtlas; P48756; -.
DR ProteomicsDB; 263360; -.
DR Antibodypedia; 3388; 389 antibodies from 29 providers.
DR Ensembl; ENSMUST00000103156.2; ENSMUSP00000099445.2; ENSMUSG00000014351.13.
DR Ensembl; ENSMUST00000103157.10; ENSMUSP00000099446.4; ENSMUSG00000014351.13.
DR GeneID; 14607; -.
DR KEGG; mmu:14607; -.
DR UCSC; uc007lba.1; mouse.
DR AGR; MGI:107504; -.
DR CTD; 2695; -.
DR MGI; MGI:107504; Gip.
DR VEuPathDB; HostDB:ENSMUSG00000014351; -.
DR eggNOG; ENOG502S7ZH; Eukaryota.
DR GeneTree; ENSGT00390000005121; -.
DR HOGENOM; CLU_146415_0_0_1; -.
DR InParanoid; P48756; -.
DR OMA; GHSRFHT; -.
DR OrthoDB; 3805553at2759; -.
DR PhylomeDB; P48756; -.
DR TreeFam; TF332333; -.
DR Reactome; R-MMU-400511; Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR Reactome; R-MMU-420092; Glucagon-type ligand receptors.
DR BioGRID-ORCS; 14607; 1 hit in 77 CRISPR screens.
DR ChiTaRS; Ctdsp1; mouse.
DR PRO; PR:P48756; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; P48756; Protein.
DR Bgee; ENSMUSG00000014351; Expressed in small intestine Peyer's patch and 31 other cell types or tissues.
DR Genevisible; P48756; MM.
DR GO; GO:0005615; C:extracellular space; ISO:MGI.
DR GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR GO; GO:0034774; C:secretory granule lumen; TAS:Reactome.
DR GO; GO:0031767; F:gastric inhibitory polypeptide receptor binding; ISO:MGI.
DR GO; GO:0031769; F:glucagon receptor binding; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0048018; F:receptor ligand activity; IDA:MGI.
DR GO; GO:0005102; F:signaling receptor binding; ISO:MGI.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:MGI.
DR GO; GO:0008344; P:adult locomotory behavior; IDA:MGI.
DR GO; GO:0055123; P:digestive system development; IEA:Ensembl.
DR GO; GO:0031018; P:endocrine pancreas development; IMP:MGI.
DR GO; GO:0035640; P:exploration behavior; IDA:MGI.
DR GO; GO:0007565; P:female pregnancy; IEA:Ensembl.
DR GO; GO:0038192; P:gastric inhibitory peptide signaling pathway; ISO:MGI.
DR GO; GO:0060291; P:long-term synaptic potentiation; ISO:MGI.
DR GO; GO:0007613; P:memory; IDA:MGI.
DR GO; GO:0043950; P:positive regulation of cAMP-mediated signaling; ISO:MGI.
DR GO; GO:0010828; P:positive regulation of glucose transmembrane transport; ISO:MGI.
DR GO; GO:0032024; P:positive regulation of insulin secretion; IDA:MGI.
DR GO; GO:0050806; P:positive regulation of synaptic transmission; ISO:MGI.
DR GO; GO:0042304; P:regulation of fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0010447; P:response to acidic pH; ISO:MGI.
DR GO; GO:0043200; P:response to amino acid; IEA:Ensembl.
DR GO; GO:0048678; P:response to axon injury; IEA:Ensembl.
DR GO; GO:0009749; P:response to glucose; IEA:Ensembl.
DR GO; GO:0033993; P:response to lipid; IEA:Ensembl.
DR GO; GO:0014070; P:response to organic cyclic compound; IEA:Ensembl.
DR GO; GO:0043434; P:response to peptide hormone; IEA:Ensembl.
DR GO; GO:0010269; P:response to selenium ion; IEA:Ensembl.
DR GO; GO:0042594; P:response to starvation; IBA:GO_Central.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IEA:Ensembl.
DR GO; GO:0019233; P:sensory perception of pain; IDA:MGI.
DR GO; GO:0070328; P:triglyceride homeostasis; ISO:MGI.
DR Gene3D; 6.10.250.590; -; 1.
DR InterPro; IPR039078; GIP.
DR InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR PANTHER; PTHR15211:SF0; GASTRIC INHIBITORY POLYPEPTIDE; 1.
DR PANTHER; PTHR15211; GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE; 1.
DR Pfam; PF00123; Hormone_2; 1.
DR SMART; SM00070; GLUCA; 1.
DR PROSITE; PS00260; GLUCAGON; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000250"
FT PROPEP 22..42
FT /id="PRO_0000011217"
FT PEPTIDE 44..85
FT /note="Gastric inhibitory polypeptide"
FT /id="PRO_0000011218"
FT PROPEP 87..144
FT /id="PRO_0000011219"
FT REGION 94..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 136
FT /note="T -> A (in Ref. 1; AAC52731)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 144 AA; 16389 MW; 36E618665D4DA8C3 CRC64;
MVALKTCSLL LVLLFLAVGL GEKEEVEFRS HAKFAGPRPR GPRYAEGTFI SDYSIAMDKI
RQQDFVNWLL AQRGKKSDWK HNITQREARA LVLAGQSQGK EDKEAQESSL PKSLSDDDVL
RDLLIQELLA WMVDQTELCR LRSQ
//
