ID   GLGA1_SYNY3             Reviewed;         477 AA.
AC   P74521;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   27-MAR-2024, entry version 129.
DE   RecName: Full=Glycogen synthase 1;
DE            EC=2.4.1.21;
DE   AltName: Full=Starch [bacterial glycogen] synthase 1;
GN   Name=glgA1; Synonyms=glgA; OrderedLocusNames=sll0945;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Merismopediaceae;
OC   Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000305}.
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DR   EMBL; BA000022; BAA18625.1; -; Genomic_DNA.
DR   PIR; S76496; S76496.
DR   AlphaFoldDB; P74521; -.
DR   SMR; P74521; -.
DR   STRING; 1148.gene:10499509; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   PaxDb; 1148-1653713; -.
DR   EnsemblBacteria; BAA18625; BAA18625; BAA18625.
DR   KEGG; syn:sll0945; -.
DR   eggNOG; COG0297; Bacteria.
DR   InParanoid; P74521; -.
DR   PhylomeDB; P74521; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd03791; GT5_Glycogen_synthase_DULL1-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   NCBIfam; TIGR02095; glgA; 1.
DR   PANTHER; PTHR45825; GRANULE-BOUND STARCH SYNTHASE 1, CHLOROPLASTIC/AMYLOPLASTIC; 1.
DR   PANTHER; PTHR45825:SF11; STARCH SYNTHASE 1, CHLOROPLASTIC_AMYLOPLASTIC; 1.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..477
FT                   /note="Glycogen synthase 1"
FT                   /id="PRO_0000188655"
FT   BINDING         15
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   477 AA;  54346 MW;  40C1B6013938E032 CRC64;
     MKILFVAAEV SPLAKVGGMG DVVGSLPKVL HQLGHDVRVF MPYYGFIGDK IDVPKEPVWK
     GEAMFQQFAV YQSYLPDTKI PLYLFGHPAF DSRRIYGGDD EAWRFTFFSN GAAEFAWNHW
     KPEIIHCHDW HTGMIPVWMH QSPDIATVFT IHNLAYQGPW RGLLETMTWC PWYMQGDNVM
     AAAIQFANRV TTVSPTYAQQ IQTPAYGEKL EGLLSYLSGN LVGILNGIDT EIYNPAEDRF
     ISNVFDADSL DKRVKNKIAI QEETGLEINR NAMVVGIVAR LVEQKGIDLV IQILDRFMSY
     TDSQLIILGT GDRHYETQLW QMASRFPGRM AVQLLHNDAL SRRVYAGADV FLMPSRFEPC
     GLSQLMAMRY GCIPIVRRTG GLVDTVSFYD PINEAGTGYC FDRYEPLDCF TAMVRAWEGF
     RFKADWQKLQ QRAMRADFSW YRSAGEYIKV YKGVVGKPEE LSPMEEEKIA ELTASYR
//