ID GLR26_ARATH Reviewed; 967 AA.
AC Q9LFN8; F4JWF4;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 2.
DT 24-JAN-2024, entry version 144.
DE RecName: Full=Glutamate receptor 2.6;
DE AltName: Full=Ligand-gated ion channel 2.6;
DE Flags: Precursor;
GN Name=GLR2.6; OrderedLocusNames=At5g11180; ORFNames=F2I11_70;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11379626; DOI=10.1126/science.292.5521.1486b;
RA Lacombe B., Becker D., Hedrich R., DeSalle R., Hollmann M., Kwak J.M.,
RA Schroeder J.I., Le Novere N., Nam H.G., Spalding E.P., Tester M.,
RA Turano F.J., Chiu J., Coruzzi G.;
RT "The identity of plant glutamate receptors.";
RL Science 292:1486-1487(2001).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=12082126; DOI=10.1093/oxfordjournals.molbev.a004165;
RA Chiu J.C., Brenner E.D., DeSalle R., Nitabach M.N., Holmes T.C.,
RA Coruzzi G.M.;
RT "Phylogenetic and expression analysis of the glutamate-receptor-like gene
RT family in Arabidopsis thaliana.";
RL Mol. Biol. Evol. 19:1066-1082(2002).
CC -!- FUNCTION: Glutamate-gated receptor that probably acts as a non-
CC selective cation channel. May be involved in light-signal transduction
CC and calcium homeostasis via the regulation of calcium influx into
CC cells.
CC -!- SUBUNIT: May form heteromers. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in roots.
CC {ECO:0000269|PubMed:12082126}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AED91643.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB96653.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL360314; CAB96653.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED91643.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; ANM68539.1; -; Genomic_DNA.
DR RefSeq; NP_001330285.1; NM_001343161.1.
DR RefSeq; NP_196679.1; NM_121156.2.
DR AlphaFoldDB; Q9LFN8; -.
DR SMR; Q9LFN8; -.
DR STRING; 3702.Q9LFN8; -.
DR GlyCosmos; Q9LFN8; 8 sites, No reported glycans.
DR PaxDb; 3702-AT5G11180-1; -.
DR EnsemblPlants; AT5G11180.2; AT5G11180.2; AT5G11180.
DR GeneID; 830988; -.
DR Gramene; AT5G11180.2; AT5G11180.2; AT5G11180.
DR KEGG; ath:AT5G11180; -.
DR Araport; AT5G11180; -.
DR TAIR; AT5G11180; GLR2.6.
DR eggNOG; KOG1052; Eukaryota.
DR InParanoid; Q9LFN8; -.
DR OMA; GDHEANR; -.
DR OrthoDB; 1011589at2759; -.
DR PhylomeDB; Q9LFN8; -.
DR PRO; PR:Q9LFN8; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LFN8; baseline and differential.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0005262; F:calcium channel activity; ISS:UniProtKB.
DR GO; GO:0008066; F:glutamate receptor activity; ISS:UniProtKB.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0006816; P:calcium ion transport; ISS:UniProtKB.
DR GO; GO:0019722; P:calcium-mediated signaling; ISS:UniProtKB.
DR GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
DR CDD; cd13686; GluR_Plant; 1.
DR CDD; cd19990; PBP1_GABAb_receptor_plant; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR044440; GABAb_receptor_plant_PBP1.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR017103; Iontropic_Glu_rcpt_pln.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR001638; Solute-binding_3/MltF_N.
DR PANTHER; PTHR18966:SF418; GLUTAMATE RECEPTOR 2.5-RELATED; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR Pfam; PF00497; SBP_bac_3; 1.
DR PIRSF; PIRSF037090; Iontro_Glu-like_rcpt_pln; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel;
KW Membrane; Receptor; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..967
FT /note="Glutamate receptor 2.6"
FT /id="PRO_0000011601"
FT TOPO_DOM 32..590
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 591..611
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 612..621
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 622..642
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 643..651
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 652..672
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 673..832
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 833..853
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 854..967
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 864..913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 864..890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 57
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 121
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 336
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 345
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 424
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 550
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 795
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 967 AA; 108965 MW; FF6F3712064F70CB CRC64;
MSLFNHLLSR ALPLWLLFFI NFLVLLGKSQ QEVLQVQVGI VLDTNATLAA LSLRAINMSL
SEFYNTHNGF KTRIVLNIRD SKRTVVGAAA SALYLIKKRE VVAIIGPGNS MQAPFLINLG
NQSQVPIISF SASSPVLDSL RSPYFIRATH DDSSQVHAIS AIIESFRWRE VVPIYADNEF
GEGILPYLVD AFQEINVRIR YRSAISVHST DDLVKKELYK LMTMPTRVFI VHMLPDLGSR
LFSIAKEIGM MTKGYVWIVT NGIADQMSVM GESSLENMHG VLGVKTYFSR SKELMYLETR
WRKRFGGEEL NNFECWGYDT ATALAMSIEE ISSNVNMSFS QTKRNTSRDD TGTDLDDLSF
ALSGPKLLQA LATVSFKGVA GRFQLKNGKL EATTFKIVNI EESGERTVGF WKSKVGLVKS
LRVNQTGIKI SHSSHRLRPI IWPGDTIFVP KGWEFPTNAK KLRIAVPKKD GFNNFVEVTK
DANTNAPTIT GFCIDVFDTA MRQMPYAVPY EYIPFETPDG KPRGSYDEMV YHVFLGEFDG
AVGDTTILAN RSTYVDFALP YSETGIVVVV PVKDEREKGK WVFLKPLTRE LWFLTAASFL
YIGIMVWIFE YQASGDFRKQ SIINKISNVF YFSFSTLFFA HMRPSESIFT RVLVVVWCFV
LLILTQSYTA TLTSMLTVQE LRPTVRHMDD LRNSGVNIGY QTGSFTFERL KQMGYKESRL
KTYDTPQEMH ELFLKKSSNG GIDAAFDEVA YVKLFMAKYC SKYTIIEPTF KADGFGFAFP
LGSPLVPDLS RQILNITEGE TMKAIENKWL LGEKHCLDST TSDSPIRLDH HSFEALFTIV
FVVSMLLLLA MLVCRRYRQE SKSGEINANN SPTDGNMRAP PNQPTDDNMR APTSPPIDDQ
VLEPPGPALN EADDQDQLLN DEVNVGDRNE VDIIVEVDPT LVHRRNLITS KTIPTRRAAL
FSRIKSA
//
