ID GP151_RAT Reviewed; 421 AA.
AC Q7TSN5;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 24-JAN-2024, entry version 114.
DE RecName: Full=Probable G-protein coupled receptor 151;
DE AltName: Full=GPCR-2037;
GN Name=Gpr151;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=14667573; DOI=10.1016/j.molbrainres.2003.09.013;
RA Berthold M., Collin M., Sejlitz T., Meister B., Lind P.;
RT "Cloning of a novel orphan G protein-coupled receptor (GPCR-2037): in situ
RT hybridization reveals high mRNA expression in rat brain restricted to
RT neurons of the habenular complex.";
RL Brain Res. Mol. Brain Res. 120:22-29(2003).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Exclusively expressed in neurons of the habenular
CC complex. The expression is particularly prominent in the medial
CC habenular nucleus, whereas the lateral habenular nucleus exhibited a
CC lower level of expression.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ564168; CAD91897.1; -; mRNA.
DR RefSeq; NP_853664.1; NM_181633.2.
DR AlphaFoldDB; Q7TSN5; -.
DR SMR; Q7TSN5; -.
DR STRING; 10116.ENSRNOP00000043810; -.
DR GlyCosmos; Q7TSN5; 1 site, No reported glycans.
DR GlyGen; Q7TSN5; 1 site.
DR PhosphoSitePlus; Q7TSN5; -.
DR PaxDb; 10116-ENSRNOP00000043810; -.
DR Ensembl; ENSRNOT00000043544.4; ENSRNOP00000043810.3; ENSRNOG00000027103.5.
DR Ensembl; ENSRNOT00055031960; ENSRNOP00055025857; ENSRNOG00055018755.
DR Ensembl; ENSRNOT00060020639; ENSRNOP00060016255; ENSRNOG00060012167.
DR Ensembl; ENSRNOT00065033417; ENSRNOP00065026729; ENSRNOG00065019838.
DR GeneID; 307475; -.
DR KEGG; rno:307475; -.
DR UCSC; RGD:727873; rat.
DR AGR; RGD:727873; -.
DR CTD; 134391; -.
DR RGD; 727873; Gpr151.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01030000234518; -.
DR HOGENOM; CLU_053982_0_0_1; -.
DR InParanoid; Q7TSN5; -.
DR OMA; CTIWSVL; -.
DR OrthoDB; 4729702at2759; -.
DR PhylomeDB; Q7TSN5; -.
DR TreeFam; TF332591; -.
DR PRO; PR:Q7TSN5; -.
DR Proteomes; UP000002494; Chromosome 18.
DR Bgee; ENSRNOG00000027103; Expressed in spleen and 8 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; ISO:RGD.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:RGD.
DR GO; GO:0010447; P:response to acidic pH; ISO:RGD.
DR CDD; cd15002; 7tmA_GPR151; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR45695:SF1; G-PROTEIN COUPLED RECEPTOR 151; 1.
DR PANTHER; PTHR45695; LEUCOKININ RECEPTOR-RELATED; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..421
FT /note="Probable G-protein coupled receptor 151"
FT /id="PRO_0000069634"
FT TOPO_DOM 1..44
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 66..74
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..122
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..156
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..258
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..289
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..421
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 346..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 18
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 114..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 421 AA; 46724 MW; 5ADAE6CA69828512 CRC64;
MGKATLAVFA DSDSSNMNES FAHLHFAGGY LPSDSKGWRT IIPSLLAAVC LVGFVGNLCV
IGLLLHGVWK RKPSMIHSLI LNLSLADISL LLFSAPVRAT AYVKGVWDLG WFVCKSSDWF
THMCMAAKSL TFVVVAKVCF MYASDPAKPV GTHNCTIWSL LGAIWVVASL LPLPEWFFST
TRHHAGVEMC LVDVPAVAAE FMSLFGKLYP LLVFCLPLLL AGFYFWRAYN QCKIRCAKTQ
NLRNQMRSKQ LTVMLLSTAV TSALLWLPEW IAWLWVWHLK AGGPMPPQGF IALSQVLMFS
ISTVNPLIFL MMSEEFKAGL KGIWKWMITR KPVVTSEVQE VPAGNIETLP GKAPSPETQT
CIPDTDRCGS PDSSKETTDK VMVPILPDVE QFWHERDVGP SAQDNDPIPW EHEGQETKGC
N
//
