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Database: UniProt
Entry: GRB2_CHICK
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Original site: GRB2_CHICK 
ID   GRB2_CHICK              Reviewed;         217 AA.
AC   Q07883;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   08-NOV-2023, entry version 121.
DE   RecName: Full=Growth factor receptor-bound protein 2;
DE   AltName: Full=Adapter protein GRB2;
DE   AltName: Full=SH2/SH3 adapter GRB2;
GN   Name=GRB2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=8262390; DOI=10.1016/0378-1119(93)90111-f;
RA   Wasenius V.-M., Merilainen J., Lehto V.-P.;
RT   "Sequence of a chicken cDNA encoding a GRB2 protein.";
RL   Gene 134:299-300(1993).
RN   [2]
RP   INTERACTION WITH LAT2.
RX   PubMed=15539154; DOI=10.1016/j.immuni.2004.09.007;
RA   Stork B., Engelke M., Frey J., Horejsi V., Hamm-Baarke A., Schraven B.,
RA   Kurosaki T., Wienands J.;
RT   "Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-
RT   regulating signal circuit in B lymphocytes.";
RL   Immunity 21:681-691(2004).
CC   -!- FUNCTION: Adapter protein that provides a critical link between cell
CC       surface growth factor receptors and the Ras signaling pathway.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Associates with activated Tyr-phosphorylated EGF receptors and
CC       PDGF receptors via its SH2 domain. Also associates to other cellular
CC       Tyr-phosphorylated proteins such as SIT1, IRS1, SHC and LNK; probably
CC       via the concerted action of both its SH2 and SH3 domains. It also seems
CC       to interact with RAS in the signaling pathway leading to DNA synthesis.
CC       Binds to and translocates the guanine nucleotide exchange factors SOS
CC       (By similarity). Interacts with phosphorylated LAT2. {ECO:0000250,
CC       ECO:0000269|PubMed:15539154}.
CC   -!- INTERACTION:
CC       Q07883; Q7L591: DOK3; Xeno; NbExp=3; IntAct=EBI-7061573, EBI-2834978;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Endosome {ECO:0000250}. Golgi apparatus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GRB2/sem-5/DRK family. {ECO:0000305}.
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DR   EMBL; L19258; AAA16318.1; -; mRNA.
DR   PIR; JT0664; JT0664.
DR   RefSeq; NP_989742.1; NM_204411.1.
DR   AlphaFoldDB; Q07883; -.
DR   BMRB; Q07883; -.
DR   SMR; Q07883; -.
DR   IntAct; Q07883; 2.
DR   MINT; Q07883; -.
DR   STRING; 9031.ENSGALP00000012993; -.
DR   PaxDb; 9031-ENSGALP00000012993; -.
DR   GeneID; 386572; -.
DR   KEGG; gga:386572; -.
DR   CTD; 2885; -.
DR   VEuPathDB; HostDB:geneid_386572; -.
DR   eggNOG; KOG3601; Eukaryota.
DR   InParanoid; Q07883; -.
DR   PhylomeDB; Q07883; -.
DR   PRO; PR:Q07883; -.
DR   Proteomes; UP000000539; Unassembled WGS sequence.
DR   GO; GO:0008180; C:COP9 signalosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005154; F:epidermal growth factor receptor binding; IBA:GO_Central.
DR   GO; GO:0001784; F:phosphotyrosine residue binding; IBA:GO_Central.
DR   GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   CDD; cd09941; SH2_Grb2_like; 1.
DR   CDD; cd11949; SH3_GRB2_C; 1.
DR   CDD; cd11946; SH3_GRB2_N; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 2.
DR   InterPro; IPR043539; Grb2-like.
DR   InterPro; IPR035643; GRB2_C_SH3.
DR   InterPro; IPR035641; GRB2_N_SH3.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR46037:SF4; GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2; 1.
DR   PANTHER; PTHR46037; PROTEIN ENHANCER OF SEVENLESS 2B; 1.
DR   Pfam; PF00017; SH2; 1.
DR   Pfam; PF00018; SH3_1; 2.
DR   PRINTS; PR00499; P67PHOX.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00452; SH3DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SMART; SM00326; SH3; 2.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   SUPFAM; SSF50044; SH3-domain; 2.
DR   PROSITE; PS50001; SH2; 1.
DR   PROSITE; PS50002; SH3; 2.
PE   1: Evidence at protein level;
KW   Cytoplasm; Endosome; Golgi apparatus; Nucleus; Reference proteome; Repeat;
KW   SH2 domain; SH3 domain.
FT   CHAIN           1..217
FT                   /note="Growth factor receptor-bound protein 2"
FT                   /id="PRO_0000088202"
FT   DOMAIN          1..58
FT                   /note="SH3 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DOMAIN          60..152
FT                   /note="SH2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT   DOMAIN          156..215
FT                   /note="SH3 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
SQ   SEQUENCE   217 AA;  25076 MW;  DDC9A84ECDC52859 CRC64;
     MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKGGFIPK NYIEMKPHPW
     FFGKIPRAKA EEMLGKQRHD GAFLIRESES APGDFSLSVK FGNDVQQFKV LRDGAGKYLL
     WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EEGELGFRRG
     DFIQVLDNSD PNWWKGACHG QTGMFPRNYV TPVNRNI
//
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