ID GRLR_DICDI Reviewed; 1604 AA.
AC Q54K11;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Metabotropic glutamate receptor-like protein R;
DE Flags: Precursor;
GN Name=grlR; ORFNames=DDB_G0287681;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=17501984; DOI=10.1186/1471-213x-7-44;
RA Prabhu Y., Mueller R., Anjard C., Noegel A.A.;
RT "GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation
RT development.";
RL BMC Dev. Biol. 7:44-44(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Increased levels found from the tight aggregation
CC stage onward. Levels stayed high during late development. Clear
CC expression at 24 hours when fruiting body formation is close to
CC completion. {ECO:0000269|PubMed:17501984}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000103; EAL63649.1; -; Genomic_DNA.
DR RefSeq; XP_637153.1; XM_632061.1.
DR AlphaFoldDB; Q54K11; -.
DR SMR; Q54K11; -.
DR STRING; 44689.Q54K11; -.
DR GlyCosmos; Q54K11; 23 sites, No reported glycans.
DR PaxDb; 44689-DDB0231992; -.
DR EnsemblProtists; EAL63649; EAL63649; DDB_G0287681.
DR GeneID; 8626248; -.
DR KEGG; ddi:DDB_G0287681; -.
DR dictyBase; DDB_G0287681; grlR.
DR eggNOG; KOG1055; Eukaryota.
DR HOGENOM; CLU_244163_0_0_1; -.
DR InParanoid; Q54K11; -.
DR OMA; STCIVSN; -.
DR PhylomeDB; Q54K11; -.
DR Reactome; R-DDI-3769402; Deactivation of the beta-catenin transactivating complex.
DR PRO; PR:Q54K11; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15047; 7tmC_GABA-B-like; 1.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 1.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR21533; LEUCINE-RICH PROTEIN; 1.
DR PANTHER; PTHR21533:SF19; LEUCINE-RICH PROTEIN; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR SUPFAM; SSF51126; Pectin lyase-like; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..1604
FT /note="Metabotropic glutamate receptor-like protein R"
FT /id="PRO_0000370361"
FT TOPO_DOM 28..1149
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1150..1170
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1171..1184
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1185..1205
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1206..1211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1212..1232
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1233..1256
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1257..1277
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1278..1304
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1305..1325
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1326..1340
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1341..1361
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1362..1372
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1373..1393
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1394..1604
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 38..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1457..1604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 98..133
FT /evidence="ECO:0000255"
FT COMPBIAS 38..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1457..1554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1573..1587
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 285
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 327
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 359
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 375
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 489
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 498
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 525
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 577
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 593
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 624
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 768
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 837
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 841
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 851
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 864
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 876
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 885
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 888
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 913
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 967
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 991
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1097
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1604 AA; 181089 MW; 4C9C49A25EB8F113 CRC64;
MVIKKPFIFI FICFLICLLI CIDLTNCNTI NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
NNNNNNNDNN ENHKILKDYL KFTKRFKKSE YPTTEQQDFY INKIKKEIKD REKYKNNIEN
EILKINSQKK RKKFKRKDLN TDIKTNHEQL RKLIENNVNP NPHYYDETQS FYFTNRMTSN
NEKNNKKNLN FNNDNNKINN LINIKNNNIP YINNNNNNNN NNNNNNNNNN KNNNNNNNNK
NNNNNNNNKN NNNNNNNKNN NKNKKIIINN NNLINNKLVS ETSANMTTMV NSGDASLRSL
INFLTTQDNN GLRFFPYSPR DLINPFNATK AISVAFAYND RQLITPGAFS KENEEIRANQ
SRSQGLFDPN SPNMNFSSFY DIIDQQQTNF VQNIELSIDY LLNQVYFKEI FSKKDFKTQA
RDFEALFEFL KQQGTRVVYY YIANDGSNHV ECGGSIKPCQ DLAYLLQSVP MADRIQTDLV
VFFYPGRYNI TKRIVIDNFS KVQLVGLFGK DETTLTSNQK MFLFNNTHIH MIGLTIADVN
FQMKPLLNIF KTDNLGTGTV FDLRQSIMTI LLCDFRNISN RNSLGSVFAY NSNLTVSNTL
FENTIAAVGG GIFCCSYSTC IVSNCTFRAN IADNPIGGGA LIASLSTLFI TQSAFYNNKA
SIGGSVIIDG GFSTVDTSTF EYNTGFVGSA IQISPNSIVY IVNCYFYFNL ATYSGASIFC
GSSTVVFISK CIFKDNYSPG ANGLESYSEK LVLIEESVFE GNIPPLLNST SVVSIASPSA
FLFVRQCSFF GHSGVIFNIG NPSVLYCSFS LFYENSNRIV NSFNNGLIVF GSCKLFNNSN
NKSDGIFRIN NRSNGIFYAV EFYNNTVSSF FESWFNSTCF LLSSNITNNT FRAGSFQVAF
STDIFVDNLL YSNNTAAEGG LISSDQTGGI SVTNSLLIGN TAEFGNLVFF RLLSYSEPNC
DSFIFENNTY VDNYAFMAGT IVYFDDTIRC NYSCINCVSV NNNAQYGEIV NTGFATFSST
LPNTIPPSII RPIILQAFDA LGLPYLGRSD ITFNLLINLL ICDQMSLTGV VQSTSTPTSF
SVFYNVRISG APGTHCNLTV IAFLKTFKNI TLEYPITVVN CQEGQDPYNI GGVNSYYCLT
DVSKTKIAKI IIGISAIIVS IGVLITAILT FIYRKRKIMR YSNPVFLLII LVGCVCGLVS
TFVSFSTTSA TCSIRMVLIP LFFFIITSAI FIKQYRVYCL IRGVEELHDM SIENSYLLKL
QSFILIIPAI LIAVSVIATR MHRKYNFDLQ KETIQAYCYS KNFYIIFICL ALYEFSILLY
GCWIVIKCRQ YRSFPGSFNE FFYIGVLIYV LTVILVVSIP IGFALLNSAL TDFLLYSIPI
LVLIVAIIGL LFAPKFYFLF RTDKVIANLR QLIEDQEEIL KKNKEVLFTY GMYLGDNNND
IIALHESFSD SDILSKTGSN TSDDVSDDFT FDSPTTYSNI PIPLNRRNNN NNNINNNNNN
NNNNNNNNNN NNNNNNNNNI LNNNKNNNND DDASSSNSSS TADFEISSSG ESGRSSNDYD
KRNNKKNRRK NSLRTPILNS LLSPNSRNKT KKRNKSSQNS PLLD
//
