ID GRXC7_ARATH Reviewed; 136 AA.
AC Q96305; Q9S7X8;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 2.
DT 24-JAN-2024, entry version 151.
DE RecName: Full=Glutaredoxin-C7;
DE Short=AtGrxC7;
DE AltName: Full=Protein ROXY 1;
GN Name=GRXC7; Synonyms=AT.I.24-1, ROXY1; OrderedLocusNames=At3g02000;
GN ORFNames=F1C9.22, F28J7.33;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=2615757; DOI=10.1007/bf00261164;
RA Axelos M., Bardet C., Liboz T., Le van Thai A., Curie C., Lescure B.;
RT "The gene family encoding the Arabidopsis thaliana translation elongation
RT factor EF-1 alpha: molecular cloning, characterization and expression.";
RL Mol. Gen. Genet. 219:106-112(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, MUTAGENESIS OF CYS-49; CYS-52 AND CYS-90, AND DISRUPTION PHENOTYPE.
RX PubMed=15728668; DOI=10.1242/dev.01725;
RA Xing S., Rosso M.G., Zachgo S.;
RT "ROXY1, a member of the plant glutaredoxin family, is required for petal
RT development in Arabidopsis thaliana.";
RL Development 132:1555-1565(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15170506; DOI=10.1007/s00018-004-3410-y;
RA Rouhier N., Gelhaye E., Jacquot J.-P.;
RT "Plant glutaredoxins: still mysterious reducing systems.";
RL Cell. Mol. Life Sci. 61:1266-1277(2004).
RN [7]
RP GENE FAMILY.
RX PubMed=16720602; DOI=10.1093/jxb/erl001;
RA Rouhier N., Couturier J., Jacquot J.-P.;
RT "Genome-wide analysis of plant glutaredoxin systems.";
RL J. Exp. Bot. 57:1685-1696(2006).
RN [8]
RP FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE, AND MUTAGENESIS OF
RP GLY-110.
RX PubMed=18036205; DOI=10.1111/j.1365-313x.2007.03375.x;
RA Xing S., Zachgo S.;
RT "ROXY1 and ROXY2, two Arabidopsis glutaredoxin genes, are required for
RT anther development.";
RL Plant J. 53:790-801(2008).
RN [9]
RP GENE FAMILY, FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH TGA2;
RP TGA3; TGA7 AND PAN.
RX PubMed=19218396; DOI=10.1105/tpc.108.064477;
RA Li S., Lauri A., Ziemann M., Busch A., Bhave M., Zachgo S.;
RT "Nuclear activity of ROXY1, a glutaredoxin interacting with TGA factors, is
RT required for petal development in Arabidopsis thaliana.";
RL Plant Cell 21:429-441(2009).
RN [10]
RP INTERACTION WITH TGA9 AND TGA10, DEVELOPMENTAL STAGE, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=cv. Columbia;
RX PubMed=20805327; DOI=10.1104/pp.110.159111;
RA Murmu J., Bush M.J., Delong C., Li S., Xu M., Khan M., Malcolmson C.,
RA Fobert P.R., Zachgo S., Hepworth S.R.;
RT "Arabidopsis basic leucine-zipper transcription factors TGA9 and TGA10
RT interact with floral glutaredoxins ROXY1 and ROXY2 and are redundantly
RT required for anther development.";
RL Plant Physiol. 154:1492-1504(2010).
CC -!- FUNCTION: Has a glutathione-disulfide oxidoreductase activity in the
CC presence of NADPH and glutathione reductase. Reduces low molecular
CC weight disulfides and proteins (By similarity). Involved in flower
CC development as a regulator of petal primorida initiation and further
CC petal morphogenesis. May mediate post-translational modifications of
CC target proteins required for normal petal organ initiation and
CC morphogenesis. ROXY1/TGA protein interactions can occur in vivo and
CC support their biological relevance in petal development. May be
CC involved in the regulation of the floral regulator class C gene AG
CC (AGAMOUS). {ECO:0000250, ECO:0000269|PubMed:15728668,
CC ECO:0000269|PubMed:18036205, ECO:0000269|PubMed:19218396}.
CC -!- SUBUNIT: Interacts with TGA2, TGA3, TGA7 and PAN (PubMed:19218396).
CC Interacts with TGA9 and TGA10 in the nucleus (PubMed:20805327).
CC {ECO:0000269|PubMed:19218396, ECO:0000269|PubMed:20805327}.
CC -!- INTERACTION:
CC Q96305; Q9SX27: PAN; NbExp=3; IntAct=EBI-2257898, EBI-2257975;
CC Q96305; Q39237: TGA1; NbExp=4; IntAct=EBI-2257898, EBI-541351;
CC Q96305; P43273: TGA2; NbExp=3; IntAct=EBI-2257898, EBI-541307;
CC Q96305; Q39234: TGA3; NbExp=6; IntAct=EBI-2257898, EBI-541366;
CC Q96305; Q93ZE2: TGA7; NbExp=3; IntAct=EBI-2257898, EBI-541400;
CC Q96305; Q84MB2: TIFY8; NbExp=3; IntAct=EBI-2257898, EBI-4426557;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P17695}. Nucleus
CC {ECO:0000269|PubMed:19218396, ECO:0000269|PubMed:20805327}.
CC -!- TISSUE SPECIFICITY: Highly expressed in inflorescences, roots, and
CC siliques. Expressed at lower levels in mature flowers.
CC {ECO:0000269|PubMed:15728668, ECO:0000269|PubMed:18036205}.
CC -!- DEVELOPMENTAL STAGE: Expressed first in the inflorescence apex, then in
CC young floral primordia, and in the petal and stamen primordia
CC (PubMed:15728668). Localized to the tapetum and middle layers
CC (PubMed:20805327). {ECO:0000269|PubMed:15728668,
CC ECO:0000269|PubMed:20805327}.
CC -!- DISRUPTION PHENOTYPE: Plants show a reduced number of petal primordia
CC and abnormalities during further petal development. Defection in
CC sporogenous cell formation in adaxial anther lobes when associated with
CC the disruption of GRXC8/ROXY2 leading to fertility defects.
CC {ECO:0000269|PubMed:15728668, ECO:0000269|PubMed:18036205}.
CC -!- SIMILARITY: Belongs to the glutaredoxin family. CC-type subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB07873.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U63815; AAB07873.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AY910752; AAX20407.1; -; mRNA.
DR EMBL; AC010797; AAF03450.1; -; Genomic_DNA.
DR EMBL; AC011664; AAF14835.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE73748.1; -; Genomic_DNA.
DR EMBL; BT024760; ABD59098.1; -; mRNA.
DR RefSeq; NP_186849.1; NM_111066.4.
DR AlphaFoldDB; Q96305; -.
DR SMR; Q96305; -.
DR BioGRID; 5534; 9.
DR IntAct; Q96305; 9.
DR STRING; 3702.Q96305; -.
DR PaxDb; 3702-AT3G02000-1; -.
DR EnsemblPlants; AT3G02000.1; AT3G02000.1; AT3G02000.
DR GeneID; 820200; -.
DR Gramene; AT3G02000.1; AT3G02000.1; AT3G02000.
DR KEGG; ath:AT3G02000; -.
DR Araport; AT3G02000; -.
DR TAIR; AT3G02000; ROXY1.
DR eggNOG; KOG1752; Eukaryota.
DR HOGENOM; CLU_026126_6_1_1; -.
DR InParanoid; Q96305; -.
DR OMA; WGSYKMN; -.
DR OrthoDB; 444481at2759; -.
DR PhylomeDB; Q96305; -.
DR PRO; PR:Q96305; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q96305; differential.
DR Genevisible; Q96305; AT.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEP:TAIR.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:TAIR.
DR GO; GO:0048441; P:petal development; IMP:TAIR.
DR GO; GO:0048451; P:petal formation; IMP:TAIR.
DR GO; GO:0048448; P:stamen morphogenesis; IMP:TAIR.
DR CDD; cd03419; GRX_GRXh_1_2_like; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR011905; GlrX-like_pln_2.
DR InterPro; IPR002109; Glutaredoxin.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR NCBIfam; TIGR02189; GlrX-like_plant; 1.
DR PANTHER; PTHR10168; GLUTAREDOXIN; 1.
DR PANTHER; PTHR10168:SF128; GLUTAREDOXIN-C7; 1.
DR Pfam; PF00462; Glutaredoxin; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Disulfide bond; Electron transport; Nucleus;
KW Redox-active center; Reference proteome; Transport.
FT CHAIN 1..136
FT /note="Glutaredoxin-C7"
FT /id="PRO_0000268714"
FT DOMAIN 29..135
FT /note="Glutaredoxin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00686"
FT MOTIF 133..136
FT /note="Responsive for interaction with TGA factors"
FT DISULFID 49..52
FT /note="Redox-active"
FT /evidence="ECO:0000250"
FT MUTAGEN 49
FT /note="C->S: Alters the function during petal development."
FT /evidence="ECO:0000269|PubMed:15728668"
FT MUTAGEN 52
FT /note="C->S: No effect on the function during petal
FT development."
FT /evidence="ECO:0000269|PubMed:15728668"
FT MUTAGEN 90
FT /note="C->S: No effect on the function during petal
FT development."
FT /evidence="ECO:0000269|PubMed:15728668"
FT MUTAGEN 110
FT /note="G->A: Affects glutathione binding."
FT /evidence="ECO:0000269|PubMed:18036205"
SQ SEQUENCE 136 AA; 14202 MW; 2D65C7BDA490AC6E CRC64;
MQYQTESWGS YKMSSLGFGG LGMVADTGLL RIESLASESA VVIFSVSTCC MCHAVKGLFR
GMGVSPAVHE LDLHPYGGDI QRALIRLLGC SGSSSPGSLP VVFIGGKLVG AMDRVMASHI
NGSLVPLLKD AGALWL
//