ID H0A7Y0_9PROT Unreviewed; 1050 AA.
AC H0A7Y0;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Efflux pump membrane transporter {ECO:0000256|RuleBase:RU364070};
GN ORFNames=HMPREF9946_04937 {ECO:0000313|EMBL:EHL96223.1};
OS Acetobacteraceae bacterium AT-5844.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae.
OX NCBI_TaxID=1054213 {ECO:0000313|EMBL:EHL96223.1, ECO:0000313|Proteomes:UP000003292};
RN [1] {ECO:0000313|EMBL:EHL96223.1, ECO:0000313|Proteomes:UP000003292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AT-5844 {ECO:0000313|Proteomes:UP000003292};
RA Weinstock G., Sodergren E., Clifton S., Fulton L., Fulton B., Courtney L.,
RA Fronick C., Harrison M., Strong C., Farmer C., Delahaunty K., Markovic C.,
RA Hall O., Minx P., Tomlinson C., Mitreva M., Hou S., Chen J., Wollam A.,
RA Pepin K.H., Johnson M., Bhonagiri V., Zhang X., Suruliraj S., Warren W.,
RA Chinwalla A., Mardis E.R., Wilson R.K.;
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU364070}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU364070}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942,
CC ECO:0000256|RuleBase:RU364070}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU364070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHL96223.1}.
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DR EMBL; AGEZ01000215; EHL96223.1; -; Genomic_DNA.
DR AlphaFoldDB; H0A7Y0; -.
DR STRING; 1054213.HMPREF9946_04937; -.
DR PATRIC; fig|1054213.3.peg.4489; -.
DR eggNOG; COG0841; Bacteria.
DR HOGENOM; CLU_002755_0_2_5; -.
DR OrthoDB; 9806532at2; -.
DR BioCyc; ABAC1054213:G1H32-4555-MONOMER; -.
DR Proteomes; UP000003292; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF13; MULTIDRUG EFFLUX PUMP SUBUNIT ACRB-RELATED; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|RuleBase:RU364070};
KW Cell membrane {ECO:0000256|RuleBase:RU364070};
KW Membrane {ECO:0000256|RuleBase:RU364070};
KW Reference proteome {ECO:0000313|Proteomes:UP000003292};
KW Transmembrane {ECO:0000256|RuleBase:RU364070};
KW Transmembrane helix {ECO:0000256|RuleBase:RU364070};
KW Transport {ECO:0000256|RuleBase:RU364070}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 340..359
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 366..390
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 438..460
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 472..497
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 537..555
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 869..887
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 894..914
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 920..941
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 969..989
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
FT TRANSMEM 1001..1024
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364070"
SQ SEQUENCE 1050 AA; 112202 MW; AAFAD438DCADB798 CRC64;
MARFFIDRPV FAWVIALGIM LIGLITLRGL PIAQYPNIAP PAIQISLSYS GASAETMQNT
VVQVIEQQMT GLDGLLYFSS DSNRDGSATI KLTFAQGTDP DIAQVQVQNK LALAESRLPE
TVRSAGIRVA KASNNFLMVV GFVSADGSMT SSDIADFVAS TVQDPLTRTT GVGDYQLFGA
QYAMRIWLDP DKLNAYGLMP SDISAAITAQ NVQIASGELG ARPAVPGQRL TATLVGPSYL
TTPEQFGAIL LKVKTDGSQV RLRDVATVEL NGQSFSITSQ YNGKPTAGLG IQLASGANAV
STAAAVRETL ARLQPSFPSS LQVVYPYDTT PFVQISIHEV VKALIEAMIL VFVVMFVFLQ
NFRATLVPTL AIPVVLLGTF AVLSFAGYSI NTLTMFGMVL AIGLLVDDAI VVVENVERVM
EQEGLSPLEA TRKSMDQISG ALVGIALVLS AVFLPMFFFA GSSGVIYRQF SLTIVTAMTL
SVIVALVFTP ALCATLLKRP KHGEKRGFFG WFNRNFDRTS RAYVGGVGFM ARRALRFMLV
YAVIAGAMGV LYTRLPSSFL PAEDQGLMFV QITAPPGATT ERTQQAVNAV NQYLLNEEKE
NVASVMAVSG FSFGGRGQAS AMAFVRLKDW EERTDAASAV SAIAGRLMRH FSTYPDAQIF
AFSPPAVPEL GNATGFDMQL LDQGGLGHAA LTAARNQLLQ AASQSPVLVG VRPNTLDDEP
QYHLVVDWER ASALGLSVSD ITNTLSAAFG SSYVNDFLDR GRVKRVYMQG VASSRMSPED
FNKWHVRNSA GEMVPFSAFS SAQWEVGPPK LSRYNGTASV EILGDAAPGH STGAAMAEME
RLAAQLPTGI GIDWTGLSYE ERASGSQAMA LYAISLIVVF LCLAALYESW AIPVSVMLVV
PLGVFGAVLA TLLRGMSNDV YFQVGLLTTI GLSAKNAILI VEFAKEHFEA GESLLDSALH
AAKERLRPIL MTSLAFVLGV VPLAIATGAG AGGRTAIGTG IIGGVVAGTV LAVFFVPLFF
ILVLKLFRTR RRSEARAAEA TPPQALEHRP
//
