ID H0E622_9ACTN Unreviewed; 347 AA.
AC H0E622;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Delta5 acyl-lipid desaturase {ECO:0000313|EMBL:EHN10880.1};
DE EC=1.14.99.- {ECO:0000313|EMBL:EHN10880.1};
GN ORFNames=PAI11_22720 {ECO:0000313|EMBL:EHN10880.1};
OS Patulibacter medicamentivorans.
OC Bacteria; Actinomycetota; Thermoleophilia; Solirubrobacterales;
OC Patulibacteraceae; Patulibacter.
OX NCBI_TaxID=1097667 {ECO:0000313|EMBL:EHN10880.1, ECO:0000313|Proteomes:UP000005143};
RN [1] {ECO:0000313|EMBL:EHN10880.1, ECO:0000313|Proteomes:UP000005143}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=I11 {ECO:0000313|EMBL:EHN10880.1,
RC ECO:0000313|Proteomes:UP000005143};
RX PubMed=23212173; DOI=10.1007/s10532-012-9610-5;
RA Almeida B., Kjeldal H., Lolas I., Knudsen A.D., Carvalho G., Nielsen K.L.,
RA Barreto Crespo M.T., Stensballe A., Nielsen J.L.;
RT "Quantitative proteomic analysis of ibuprofen-degrading Patulibacter sp.
RT strain I11.";
RL Biodegradation 24:615-630(2013).
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- SIMILARITY: Belongs to the fatty acid desaturase type 1 family.
CC {ECO:0000256|ARBA:ARBA00009295}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHN10880.1}.
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DR EMBL; AGUD01000198; EHN10880.1; -; Genomic_DNA.
DR AlphaFoldDB; H0E622; -.
DR PATRIC; fig|1097667.3.peg.2252; -.
DR OrthoDB; 104711at2; -.
DR Proteomes; UP000005143; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd03507; Delta12-FADS-like; 1.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR012171; Fatty_acid_desaturase.
DR PANTHER; PTHR32100:SF35; OMEGA-3 FATTY ACID DESATURASE FAT-1; 1.
DR PANTHER; PTHR32100; OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC; 1.
DR Pfam; PF00487; FA_desaturase; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000313|EMBL:EHN10880.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005143};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 65..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 195..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 66..303
FT /note="Fatty acid desaturase"
FT /evidence="ECO:0000259|Pfam:PF00487"
SQ SEQUENCE 347 AA; 38429 MW; 340251E312C5859D CRC64;
MSTTTITPGV SSEADAPGPA SWKAVLAPYA KPRVSRSLLD LATSVVPYVA LFAAMYLLLD
VSYLLTLALA IPTAGFLLRT YIVFHDCAHG SFLPTKRGNL WLGRVMALIV YTPFSAWRHE
HAVHHATAGD LDRRGGGDVP TLTVDEYLAQ SWGGRFGYRL FRNPWVMFTI GPFYALVIQP
RLVNKDARPR IKNSVHLTNV ALALAIAGLC LLMGPIQFLL VQAPLVLLAG GAGVWLFYVQ
HQFEDVYWES GEKWSYADAA LQGSSYLKLP QPLQFFTGNI GLHHVHHLSA RIPNYNLQRA
HDENEIFHDV PVLSFLDGMK ATRLKLWCRE RGRLVTFAEA HAVAAAA
//
