ID H0EFE4_GLAL7 Unreviewed; 839 AA.
AC H0EFE4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 22-FEB-2023, entry version 41.
DE RecName: Full=beta-glucosidase {ECO:0000256|ARBA:ARBA00012744, ECO:0000256|RuleBase:RU361161};
DE EC=3.2.1.21 {ECO:0000256|ARBA:ARBA00012744, ECO:0000256|RuleBase:RU361161};
GN ORFNames=M7I_1217 {ECO:0000313|EMBL:EHL02702.1};
OS Glarea lozoyensis (strain ATCC 74030 / MF5533).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1104152 {ECO:0000313|EMBL:EHL02702.1, ECO:0000313|Proteomes:UP000005446};
RN [1] {ECO:0000313|EMBL:EHL02702.1, ECO:0000313|Proteomes:UP000005446}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 74030 / MF5533 {ECO:0000313|Proteomes:UP000005446};
RX PubMed=22302591; DOI=10.1128/EC.05302-11;
RA Youssar L., Gruening B.A., Erxleben A., Guenther S., Huettel W.;
RT "Genome sequence of the fungus Glarea lozoyensis: the first genome sequence
RT of a species from the Helotiaceae family.";
RL Eukaryot. Cell 11:250-250(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-glucosyl residues
CC with release of beta-D-glucose.; EC=3.2.1.21;
CC Evidence={ECO:0000256|ARBA:ARBA00000448,
CC ECO:0000256|RuleBase:RU361161};
CC -!- PATHWAY: Glycan metabolism; cellulose degradation.
CC {ECO:0000256|ARBA:ARBA00004987, ECO:0000256|RuleBase:RU361161}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 3 family.
CC {ECO:0000256|ARBA:ARBA00005336, ECO:0000256|RuleBase:RU361161}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHL02702.1}.
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DR EMBL; AGUE01000020; EHL02702.1; -; Genomic_DNA.
DR AlphaFoldDB; H0EFE4; -.
DR HOGENOM; CLU_004542_2_0_1; -.
DR InParanoid; H0EFE4; -.
DR UniPathway; UPA00696; -.
DR Proteomes; UP000005446; Unassembled WGS sequence.
DR GO; GO:0008422; F:beta-glucosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0102483; F:scopolin beta-glucosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030245; P:cellulose catabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.1700; Glycoside hydrolase family 3 C-terminal domain; 1.
DR Gene3D; 3.20.20.300; Glycoside hydrolase, family 3, N-terminal domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR026891; Fn3-like.
DR InterPro; IPR019800; Glyco_hydro_3_AS.
DR InterPro; IPR002772; Glyco_hydro_3_C.
DR InterPro; IPR036881; Glyco_hydro_3_C_sf.
DR InterPro; IPR001764; Glyco_hydro_3_N.
DR InterPro; IPR036962; Glyco_hydro_3_N_sf.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR42715; BETA-GLUCOSIDASE; 1.
DR PANTHER; PTHR42715:SF12; BETA-GLUCOSIDASE A-RELATED; 1.
DR Pfam; PF14310; Fn3-like; 1.
DR Pfam; PF00933; Glyco_hydro_3; 1.
DR Pfam; PF01915; Glyco_hydro_3_C; 1.
DR PRINTS; PR00133; GLHYDRLASE3.
DR SMART; SM01217; Fn3_like; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF52279; Beta-D-glucan exohydrolase, C-terminal domain; 1.
DR PROSITE; PS00775; GLYCOSYL_HYDROL_F3; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277,
KW ECO:0000256|RuleBase:RU361161};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361161};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361161};
KW Polysaccharide degradation {ECO:0000256|ARBA:ARBA00023326,
KW ECO:0000256|RuleBase:RU361161};
KW Reference proteome {ECO:0000313|Proteomes:UP000005446};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..839
FT /note="beta-glucosidase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003532388"
FT DOMAIN 761..829
FT /note="Fibronectin type III-like"
FT /evidence="ECO:0000259|SMART:SM01217"
FT REGION 711..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 839 AA; 90224 MW; 3DEAED4AF2831D55 CRC64;
MLWSSSLASI VVLAASASAQ LDGAQSPPSY PSPWMRGGNG WQDAYAKAQA FVSQLTLLEK
VNLTTGVGWE GEACVGNTGS IPRLGFRGFC LQDSPLGIRF ADQASAFPSG MNVAATWTTR
LFKSRGRAMG DEHRGKGIDV QLGPVAGPLG RVPAGGRNWE GFSPDPVLTG VAIGETIKGI
QDGGVIANAK HYIMNEQEHN REPSGSFAAY SANVDDKTMH ETYLWPFADA VHAGVASIMC
SYNQINNSYG SQNSYTLNYL LKNELDFQGF VVSDWWAQHT GVASALAGLD MTMAGDQGLA
SGNTYWGGNL TAAAINGTLP QWRLDDMVTR IMAAYYKVGR DTARVDVNFN SWSSETYGYI
HPQANEGYQQ INYHVNVQSD HAKLIREIGG ASTVMLKNVN NALPLKKPKS VAVIGEDAHD
NPGGPNACGD RGCNTGTLAM GWGSGTANFP YLIAPVTALR AQAAKDRTLF ANVSNNYDLD
AAAKAASNAS VAIVFANADS GEAYITVDGN SGDRNNLTLW GNGDALIKKV ASVNPNTIVV
LHTVGAVIVE DLKNNPNVTA ILWAGLPGQE SGNAITDIIY GYRNPSAKSV FTWGKKREDW
GVDVIYTPTS NPPQLNFNEG NFIDYRYFDA NNIEPSYEFG FGLSYTNYSY SNLQISKNDP
GPYQPTVGMT KAAPTLGTID KDPAHAEFPT GFRAVFKYIY PYLTGPVLTN QPESWPAKSQ
DGSPQPRVGA GGSAGGNRQL WDVMYTVSCT VTNTGGVKGT EIPQLYLSLG APTDPKIVLR
GFDDLILDPG ESNTFTYKLT RRDISNWDPV TQNWVISPYP KTVYVGASSR DLKLKGVLP
//
