ID H0ELF8_GLAL7 Unreviewed; 713 AA.
AC H0ELF8;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Putative FAD-linked oxidoreductase {ECO:0000313|EMBL:EHL00677.1};
GN ORFNames=M7I_3421 {ECO:0000313|EMBL:EHL00677.1};
OS Glarea lozoyensis (strain ATCC 74030 / MF5533).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1104152 {ECO:0000313|EMBL:EHL00677.1, ECO:0000313|Proteomes:UP000005446};
RN [1] {ECO:0000313|EMBL:EHL00677.1, ECO:0000313|Proteomes:UP000005446}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 74030 / MF5533 {ECO:0000313|Proteomes:UP000005446};
RX PubMed=22302591; DOI=10.1128/EC.05302-11;
RA Youssar L., Gruening B.A., Erxleben A., Guenther S., Huettel W.;
RT "Genome sequence of the fungus Glarea lozoyensis: the first genome sequence
RT of a species from the Helotiaceae family.";
RL Eukaryot. Cell 11:250-250(2012).
CC -!- SIMILARITY: Belongs to the oxygen-dependent FAD-linked oxidoreductase
CC family. {ECO:0000256|ARBA:ARBA00005466}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHL00677.1}.
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DR EMBL; AGUE01000076; EHL00677.1; -; Genomic_DNA.
DR AlphaFoldDB; H0ELF8; -.
DR HOGENOM; CLU_432130_0_0_1; -.
DR InParanoid; H0ELF8; -.
DR UniPathway; UPA00057; UER00099.
DR Proteomes; UP000005446; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0004631; F:phosphomevalonate kinase activity; IEA:InterPro.
DR GO; GO:0006695; P:cholesterol biosynthetic process; IEA:InterPro.
DR GO; GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 3.40.462.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR012951; BBE.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR006094; Oxid_FAD_bind_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005919; Pmev_kin_anim.
DR PANTHER; PTHR42973; BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED; 1.
DR PANTHER; PTHR42973:SF25; PHOSPHOMEVALONATE KINASE; 1.
DR Pfam; PF08031; BBE; 1.
DR Pfam; PF01565; FAD_binding_4; 1.
DR Pfam; PF04275; P-mevalo_kinase; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000005446}.
FT DOMAIN 9..201
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
SQ SEQUENCE 713 AA; 77636 MW; C07CF9BBDF6FE1C5 CRC64;
MAVKNREARL HRPAAIMRPT EVRHVQQCVR WALKHGVGLT VIGGGHGGQC LWPNVVAVDM
SNFNAIHILP EEQSAQDLNR NSGPLVVVEA GCKTGDIIGS TMGAGVTVPL GSRPSVGAGL
WLQGGIGHLA RIHGLACDSI VGAVVVSVSS GHIVYAGCVP SQYRPAGAVL AENESDLLWA
IKGAGTNFGI VVSVTFESHK ALKFLTRNWI LPLKNSREAE IKLNEFDSVV AKKLTRNNSA
DAYLYWDAGK LHLGVTVYES STKEISYTTH TSGDVSAVLG MEHGYQIVDA VGLFDTEMYM
SRMHGGHSGG KTSSFKRCVF LKNIGEANIA NRLIAAIEAR PASFCYLHLL HGGGAVTDIA
PEATAFGCRD WDFACVITSV WPRDQDGGEV AQAAVTWVYS VVEDLSSLSC GVYGADLGPD
PRDAALAARA FGPNLPRLAK LKRDFDPHNV LAYACPLPRA TTKQRLIILI TGESFAGKDY
CAEIWLSAFN RCSGVKAKVV SISSATKREY AVATGASITL LLNDRTYKEQ HREALTAFFN
EQLKQRPQML SEQFLDAVQA ASDVDVLMIS GMREDAPVAR YSHLVPDSRL IEVYIETSQQ
TRQIRRGHYG IGNYTSHNDG PPKRLNYRPT FTFHNNKPGT NPPKQFFETH LLPILHTDLE
RLTKQLLGED GVGVEDVNAM VVAEFPVHQG RELLRKRGFG RVGVQSLLVF EDA
//
