ID H0ETH5_GLAL7 Unreviewed; 669 AA.
AC H0ETH5;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=Acetyl-coenzyme A synthetase {ECO:0000256|RuleBase:RU361147};
DE EC=6.2.1.1 {ECO:0000256|RuleBase:RU361147};
GN ORFNames=M7I_6038 {ECO:0000313|EMBL:EHK98166.1};
OS Glarea lozoyensis (strain ATCC 74030 / MF5533).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1104152 {ECO:0000313|EMBL:EHK98166.1, ECO:0000313|Proteomes:UP000005446};
RN [1] {ECO:0000313|EMBL:EHK98166.1, ECO:0000313|Proteomes:UP000005446}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 74030 / MF5533 {ECO:0000313|Proteomes:UP000005446};
RX PubMed=22302591; DOI=10.1128/EC.05302-11;
RA Youssar L., Gruening B.A., Erxleben A., Guenther S., Huettel W.;
RT "Genome sequence of the fungus Glarea lozoyensis: the first genome sequence
RT of a species from the Helotiaceae family.";
RL Eukaryot. Cell 11:250-250(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC ChEBI:CHEBI:456215; EC=6.2.1.1;
CC Evidence={ECO:0000256|RuleBase:RU361147};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432, ECO:0000256|RuleBase:RU361147}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK98166.1}.
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DR EMBL; AGUE01000163; EHK98166.1; -; Genomic_DNA.
DR AlphaFoldDB; H0ETH5; -.
DR HOGENOM; CLU_000022_3_6_1; -.
DR InParanoid; H0ETH5; -.
DR Proteomes; UP000005446; Unassembled WGS sequence.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361147};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU361147};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU361147};
KW Reference proteome {ECO:0000313|Proteomes:UP000005446}.
FT DOMAIN 45..101
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 103..492
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 550..628
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 669 AA; 74111 MW; D8811C2EBB896223 CRC64;
MSEGDVKPSS GPVVAEAHQV DTFHPPEKMF AKHPSKPHIK DLEEYQKMYK ESITEPEKFW
GNMAHDLLSW QTDFKTVHAG SFENGDNSWF LEGQLNASYN CVDRHAIKNP DKTAIIYEAD
ETSDGRTLSY SELLRQVCKT AYVLKQMGVK KGDTVAIYLP MIPEAVIAFL ACARIGAVHS
VVFAGFSADS LRDRVIDAQS KVVITTDEGK RGGKLIGTKK IVDDALKQCP DVTHCLVYKR
TGAEVPWTEG RDWWWHDEVD KWPAYIAPEP MNSEDPLFLL YTSGSTGKPK GVMHSTAGYL
LGAAATGKYV FDIHDTDKFF CGGDVGWITG HTYVVYAPLL LGVATVVFEG TPAYPNFSRY
WDVIEKHGVT QFYVAPTALR LLKRAGNEHI KHQMKHLRVL GSVGEPIAAE VWKWYFEIVG
KEEAHVVDTY WQTETGSHVI TPLAGVTPTK PGSASLPFFG IEPAIIDPVS GEEIHGNDVE
GVLAFKQPWP SMARTVWGAH KRYMDTYLNV YKGYYFTGDG AGRDHEGYYW IRGRVDDVVN
VSGHRLSTAE IEAALIEHPA VAEAAVVGIT DELTGQAVNA FVAIKDGNEV NDALKKDLVL
QVRKSIGPFA APKAIFVVPD LPKTRSGKIM RRILRKILAK EEDQLGDTST LSDPSVVDKI
IETVQASRK
//
