ID H0EYW9_GLAL7 Unreviewed; 678 AA.
AC H0EYW9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Putative Phosphoinositide 3-phosphatase {ECO:0000313|EMBL:EHK96272.1};
GN ORFNames=M7I_8030 {ECO:0000313|EMBL:EHK96272.1};
OS Glarea lozoyensis (strain ATCC 74030 / MF5533).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Helotiaceae; Glarea.
OX NCBI_TaxID=1104152 {ECO:0000313|EMBL:EHK96272.1, ECO:0000313|Proteomes:UP000005446};
RN [1] {ECO:0000313|EMBL:EHK96272.1, ECO:0000313|Proteomes:UP000005446}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 74030 / MF5533 {ECO:0000313|Proteomes:UP000005446};
RX PubMed=22302591; DOI=10.1128/EC.05302-11;
RA Youssar L., Gruening B.A., Erxleben A., Guenther S., Huettel W.;
RT "Genome sequence of the fungus Glarea lozoyensis: the first genome sequence
RT of a species from the Helotiaceae family.";
RL Eukaryot. Cell 11:250-250(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-
CC phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol) + phosphate; Xref=Rhea:RHEA:12316, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088; EC=3.1.3.64;
CC Evidence={ECO:0000256|ARBA:ARBA00001291};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHK96272.1}.
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DR EMBL; AGUE01000262; EHK96272.1; -; Genomic_DNA.
DR AlphaFoldDB; H0EYW9; -.
DR HOGENOM; CLU_001839_5_1_1; -.
DR InParanoid; H0EYW9; -.
DR Proteomes; UP000005446; Unassembled WGS sequence.
DR GO; GO:0004438; F:phosphatidylinositol-3-phosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF8; PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005446}.
FT DOMAIN 108..554
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT REGION 412..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 415..432
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 316
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-1"
FT BINDING 252..253
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT BINDING 316..322
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
SQ SEQUENCE 678 AA; 75152 MW; 31D98AFAC4549978 CRC64;
MTDNLKTPKV NTRKSAEINP PKDLLQVEDV QLLAEGITTV VTLHLKAHHL ICYSSPSTPP
QGTSTPSKPA KSRSVVFAYA LFSSVIYRPT PPTSSHQSSI RIRTRDFRFA RLIFNQDKQA
RDVFETLKSW NRSIQDEKLV AACFSASAPL AERDVNSSIS SRASPASSQV DLDLEKVEGE
LSDTEKLEDQ MISASSKIEI QDAPHIYGAQ QNNLIVDARP TVNALAMQAA GKGSENMEHY
KFAKKAYLGI DNIHVMRKSL DVVIEAIKDS DVSKLPPNRD LLAKSGWLKH ITGVLDGSAL
IARQVGIQHS HVLIHCSDGW DRTSQLSALS QLMLDPYYRT IEGFVVLVEK DWLSYGHMFQ
LRGGYLNSEK WFKIDKDAMA GSAINPGDRG EGRSDTFETL FQGTKRLFAK TQTSAQDHAD
RESGDLLEDA KSANSAKEAT DLENISPIFH QFLDATYQLL HQHPTRFEFN ERFLKRMLYH
LYSCQYGTFL YNNEKSRLDA RVHERTNSVW GYFLANKVQF LNPQYNGEIN DNVRGQERLL
FPKLDKVRWW NDVFNRSDAD MNGPSNAVTE RYLGGDMTPD RGRSSPSPRP NPNNLGINQG
VLTGVETAHA ALTVNRTSSP TRVVSNGAVA GFATLRDGIA GLGLGKGKSA SGSSSGANGG
NSPASWKGKG REMEVEMQ
//
