ID   H0GFJ5_SACCK            Unreviewed;       859 AA.
AC   H0GFJ5;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   SubName: Full=Alr2p {ECO:0000313|EMBL:EHN07398.1};
GN   ORFNames=VIN7_1475 {ECO:0000313|EMBL:EHN07398.1};
OS   Saccharomyces cerevisiae x Saccharomyces kudriavzevii (strain VIN7)
OS   (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=1095631 {ECO:0000313|EMBL:EHN07398.1, ECO:0000313|Proteomes:UP000009009};
RN   [1] {ECO:0000313|EMBL:EHN07398.1, ECO:0000313|Proteomes:UP000009009}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VIN7 {ECO:0000313|EMBL:EHN07398.1,
RC   ECO:0000313|Proteomes:UP000009009};
RX   PubMed=22136070; DOI=10.1111/j.1567-1364.2011.00773.x;
RA   Borneman A.R., Desany B.A., Riches D., Affourtit J.P., Forgan A.H.,
RA   Pretorius I.S., Egholm M., Chambers P.J.;
RT   "The genome sequence of the wine yeast VIN7 reveals an allotriploid hybrid
RT   genome with Saccharomyces cerevisiae and Saccharomyces kudriavzevii
RT   origins.";
RL   FEMS Yeast Res. 12:88-96(2012).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35)
CC       family. {ECO:0000256|ARBA:ARBA00009765}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EHN07398.1}.
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DR   EMBL; AGVY01000020; EHN07398.1; -; Genomic_DNA.
DR   HOGENOM; CLU_007127_6_0_1; -.
DR   PhylomeDB; H0GFJ5; -.
DR   Proteomes; UP000009009; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd12829; Alr1p-like; 1.
DR   Gene3D; 3.30.460.20; CorA soluble domain-like; 1.
DR   Gene3D; 1.20.58.340; Magnesium transport protein CorA, transmembrane region; 2.
DR   InterPro; IPR044089; Alr1-like.
DR   InterPro; IPR045861; CorA_cytoplasmic_dom.
DR   InterPro; IPR045863; CorA_TM1_TM2.
DR   InterPro; IPR002523; MgTranspt_CorA/ZnTranspt_ZntB.
DR   PANTHER; PTHR21535; MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8; 1.
DR   PANTHER; PTHR21535:SF55; MAGNESIUM TRANSPORTER ALR1-RELATED; 1.
DR   Pfam; PF01544; CorA; 2.
DR   SUPFAM; SSF143865; CorA soluble domain-like; 1.
DR   SUPFAM; SSF144083; Magnesium transport protein CorA, transmembrane region; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        738..761
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        773..797
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          1..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          118..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          369..394
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..67
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..90
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   859 AA;  96809 MW;  1797A0A888C44090 CRC64;
     MSSLSTSFDS SSDLPRSKPV DNTAASMKTG KYPKLENYRQ YSDAQPIRHE ALALKVDETK
     DSKHKFSSSN GENSGVENGG YGEKTNTFTS GRMDFEGEAE AEAVKRYQLR SSALLSSNAR
     PSRLAKSETH QKQIHVESIA PSLPKNAALE RGHDMALPAD ASSNRCNLEA SSSARTFTNV
     RKASLVSAIF ETSAESEHGT HPKQAKLKRR TYSTISTHSS VNPTTLLTRT ASQKSDMGND
     TRRTKPLRMD SRVSFHSEIS QASRDSHETE EDVCFPMFRL LHTRVNGVDF DELEEYAQIS
     NAERNLSLAN HQRHSERTYN HIGQDTGFTN SASTSGSSAA LKYTPVISRT LEKNCSINEM
     YVSENNESVR EDDKPDLHPD VTFGRNKIEG EKEGNDSSYS RAYYTLQNTE YQIPSRFSFF
     RSESDETVHA SDIPSLISEG QTFYELFKGG DPTWWLDCSC PTDDEMRCIA KTFGIHPLTA
     EDIRMQETRE KVELFKSYYF VCFHTXENDK ESENYLEPIN VYIVVFRSGV LTFHFDPISH
     CANVRRRVRQ LRDYVSVNSD WLCYALIDDI TDSFAPVIQS IEYEADSIDD SVFMTRDMDF
     AAMLQRIGES RRKTMTLMRL LSGKADVIKM FAKRCQDETN DIGPVLKSQT NMVNVQAEQE
     NVNQNNSNNQ ISLSNSYMQT TSQPRGDIAL YLGDIQDHLL TMFQNLLAYE KIFSRSHANY
     LAQLQVESFN SNNKVTEMLG KVTMLGTMLV PLNVITGLFG MNVKVPGRNG SIAWWYGILG
     VLLLLAVISW FLASYWIKKI DPPATLNEAA GSGAKSVISS FFTVKEDKRF NDDSKNGDAR
     VSVRRKSTVS LPSRYSRYN
//