ID H0GZ94_SACCK Unreviewed; 847 AA.
AC H0GZ94;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-FEB-2012, sequence version 1.
DT 22-FEB-2023, entry version 27.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN ORFNames=VIN7_9117 {ECO:0000313|EMBL:EHN00888.1};
OS Saccharomyces cerevisiae x Saccharomyces kudriavzevii (strain VIN7)
OS (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=1095631 {ECO:0000313|EMBL:EHN00888.1, ECO:0000313|Proteomes:UP000009009};
RN [1] {ECO:0000313|EMBL:EHN00888.1, ECO:0000313|Proteomes:UP000009009}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VIN7 {ECO:0000313|EMBL:EHN00888.1,
RC ECO:0000313|Proteomes:UP000009009};
RX PubMed=22136070; DOI=10.1111/j.1567-1364.2011.00773.x;
RA Borneman A.R., Desany B.A., Riches D., Affourtit J.P., Forgan A.H.,
RA Pretorius I.S., Egholm M., Chambers P.J.;
RT "The genome sequence of the wine yeast VIN7 reveals an allotriploid hybrid
RT genome with Saccharomyces cerevisiae and Saccharomyces kudriavzevii
RT origins.";
RL FEMS Yeast Res. 12:88-96(2012).
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC multimeric enzyme that catalyzes the translocation of protons across
CC the membranes. Required for assembly and activity of the V-ATPase.
CC {ECO:0000256|RuleBase:RU361189}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EHN00888.1}.
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DR EMBL; AGVY01000329; EHN00888.1; -; Genomic_DNA.
DR AlphaFoldDB; H0GZ94; -.
DR HOGENOM; CLU_005230_0_0_1; -.
DR PhylomeDB; H0GZ94; -.
DR Proteomes; UP000009009; Unassembled WGS sequence.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629:SF59; V-TYPE PROTON ATPASE SUBUNIT A, GOLGI ISOFORM; 1.
DR PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 423..447
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 467..485
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 545..565
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 577..597
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 639..656
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT TRANSMEM 786..808
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361189"
FT COILED 83..110
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 847 AA; 97178 MW; 605C823BE9C4E780 CRC64;
MDLNKDLTAF QRGYVNQLRR FDEVERMVIF LNEVVEKHAA ETWKYILHID DEGNDIAQPD
MLNLINTMEL LSLDNVNDMV REITDCESRA RQLDESLDNL RIKLNDLLEQ RQVIFECSKF
IEVNPGIAGR ARNPEIEREE RDVDDFRLNP DNVSETLSDT FSFDDGMSEN PDTLRDGILG
NQSTEDLSFL EQGYQHRYMI TGSIRRTKVD VLNRILWRLL RGNLIFQNFP IEEPLLEGRE
KVEKDCFIVF THGETLLKKV KRVIDSLNGK IVSLNARSSE LIDTLNHQID DLQRILYTTE
QTLHTELLVI HDQLPIWSAM TKREKYVYTT LNKFQQESQG LIAEGWVPST ELIHLQDYLK
DYIETLGSEY STVFNVILTN KLPPTYHRTN KFTQAFQSIV DAYGIATYKE INAGLATVVT
FPFMFAIMFG DMGHGLILFL MALFLVLNER KFGAMRRDEI FDMAFTGRYV VLLMGAFSVY
TGLLYNDIFS KSMTLFRSGW QWPSTFRKGE SIEAKKTGVY PFGLDFAWHG TDNGLLFSNS
YKMKLSILMG YAHMTYSFMF SYINFRAKNS KVDIIGNFIP GLVFMQSIFG YLSWAIVYKW
SKDWVKDDKP APGLLNMLIN MFLAPGTIDD QLYPGQAKLQ VVLLLAALIC VPWLLLDKPL
TLKRINKNNV GVRPHGYQSV DNIEQDEQLA QQRHSAEGFQ GMIISDIADS INENVAGDEH
GTFNFGDVMI HQVIHTIEFC LNCISHTASY LRLWALSLAH AQLSSVLWDM TISNAFSSKN
SGSPLAVIKV VFLFAMWFVL TVCILVFMEG TSAMLHALRL HWVEAMSKFF EGEGYAYEPF
SFQAIIE
//
