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Database: UniProt
Entry: H0QIP4_ARTGO
LinkDB: H0QIP4_ARTGO
Original site: H0QIP4_ARTGO 
ID   H0QIP4_ARTGO            Unreviewed;       312 AA.
AC   H0QIP4;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   22-NOV-2017, entry version 35.
DE   RecName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000256|RuleBase:RU910714};
DE            Short=HIBADH {ECO:0000256|RuleBase:RU910714};
DE            EC=1.1.1.31 {ECO:0000256|RuleBase:RU910714};
GN   Name=mmsB {ECO:0000313|EMBL:GAB12695.1};
GN   ORFNames=ARGLB_027_00240 {ECO:0000313|EMBL:GAB12695.1};
OS   Arthrobacter globiformis NBRC 12137.
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Arthrobacter.
OX   NCBI_TaxID=1077972 {ECO:0000313|EMBL:GAB12695.1, ECO:0000313|Proteomes:UP000003828};
RN   [1] {ECO:0000313|EMBL:GAB12695.1, ECO:0000313|Proteomes:UP000003828}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 12137 {ECO:0000313|EMBL:GAB12695.1,
RC   ECO:0000313|Proteomes:UP000003828};
RA   Miyazawa S., Hosoyama A., Tsuchikane K., Katsumata H., Yamazaki S.,
RA   Fujita N.;
RT   "Whole genome shotgun sequence of Arthrobacter globiformis NBRC
RT   12137.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 3-hydroxy-2-methylpropanoate + NAD(+) = 2-
CC       methyl-3-oxopropanoate + NADH. {ECO:0000256|RuleBase:RU910714}.
CC   -!- PATHWAY: Amino-acid degradation; L-valine degradation.
CC       {ECO:0000256|RuleBase:RU910714}.
CC   -!- SIMILARITY: Belongs to the 3-hydroxyisobutyrate dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU910714}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:GAB12695.1}.
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DR   EMBL; BAEG01000027; GAB12695.1; -; Genomic_DNA.
DR   RefSeq; WP_003799099.1; NZ_BAEG01000027.1.
DR   ProteinModelPortal; H0QIP4; -.
DR   EnsemblBacteria; GAB12695; GAB12695; ARGLB_027_00240.
DR   OrthoDB; POG091H02BQ; -.
DR   UniPathway; UPA00362; -.
DR   Proteomes; UP000003828; Unassembled WGS sequence.
DR   GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro.
DR   GO; GO:0006574; P:valine catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR011548; HIBADH.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR029154; NADP-bd.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01692; HIBADH; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   3: Inferred from homology;
KW   Branched-chain amino acid catabolism {ECO:0000256|RuleBase:RU910714};
KW   Complete proteome {ECO:0000313|Proteomes:UP000003828};
KW   NAD {ECO:0000256|RuleBase:RU910714};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU910714};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003828}.
FT   DOMAIN       15    175       NAD_binding_2. {ECO:0000259|Pfam:
FT                                PF03446}.
FT   DOMAIN      179    303       NAD_binding_11. {ECO:0000259|Pfam:
FT                                PF14833}.
FT   ACT_SITE    185    185       {ECO:0000256|PIRSR:PIRSR000103-1}.
SQ   SEQUENCE   312 AA;  31913 MW;  C57AD2D898B4DEC4 CRC64;
     MPEEVTRAEE AKPRVAFLGL GHMGGPMAVN LVKAGYDVVG FDVVPAALEA ARGHGIPVAA
     SAAETIPGAD VVLTMFPSGQ HVLDAYRGGD GQPGLLEAAA PNTMFLDCST INVDEAREAA
     RLALDAGHRS VDAPVSGGVV GAEAGTLTFM VGALQEDFET VRPLFDVMGK RAVLCGEHGA
     GQAAKVCNNL ILGVSMIAVS EAFVLGEKLG LTHQALFDVA SAASGQCWAL TTNCPVPGPV
     PTSPANRDYQ PGFAGALMAK DLRLALNALQ STGVAARMGP LASDIYDAFA AEGGAGRDFS
     GIITDIRDKS GQ
//
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