ID   H0QXN6_9ACTN            Unreviewed;       224 AA.
AC   H0QXN6;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Na(+)/H(+) antiporter subunit E {ECO:0000313|EMBL:GAB17587.1};
GN   Name=mrpE {ECO:0000313|EMBL:GAB17587.1};
GN   ORFNames=GOEFS_036_00260 {ECO:0000313|EMBL:GAB17587.1};
OS   Gordonia effusa NBRC 100432.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC   Gordonia.
OX   NCBI_TaxID=1077974 {ECO:0000313|EMBL:GAB17587.1, ECO:0000313|Proteomes:UP000035034};
RN   [1] {ECO:0000313|EMBL:GAB17587.1, ECO:0000313|Proteomes:UP000035034}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 100432 {ECO:0000313|EMBL:GAB17587.1,
RC   ECO:0000313|Proteomes:UP000035034};
RA   Yoshida I., Takarada H., Hosoyama A., Tsuchikane K., Katsumata H.,
RA   Yamazaki S., Fujita N.;
RT   "Whole genome shotgun sequence of Gordonia effusa NBRC 100432.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E
CC       family. {ECO:0000256|ARBA:ARBA00006228}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAB17587.1}.
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DR   EMBL; BAEH01000036; GAB17587.1; -; Genomic_DNA.
DR   RefSeq; WP_007316925.1; NZ_BAEH01000036.1.
DR   AlphaFoldDB; H0QXN6; -.
DR   STRING; 1077974.GOEFS_036_00260; -.
DR   eggNOG; COG1863; Bacteria.
DR   OrthoDB; 3556991at2; -.
DR   Proteomes; UP000035034; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR002758; Cation_antiport_E.
DR   PANTHER; PTHR34584; NA(+)/H(+) ANTIPORTER SUBUNIT E1; 1.
DR   PANTHER; PTHR34584:SF1; NA(+)_H(+) ANTIPORTER SUBUNIT E1; 1.
DR   Pfam; PF01899; MNHE; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035034};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        50..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        72..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        100..125
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   224 AA;  25664 MW;  DFFC9150CA285D53 CRC64;
     MSFRSAVVNA WRLSLLSIFW AVVSALVWVR GHIRLPRWLG SDSREVAVRL WTLAWLTFVW
     VLLWGVVSWA NVIAGLVLAI AVVTLLPLPR VPVEGRIHPL SLAILVIRLL YDFAVSSFQV
     GWMALRPGKP PLGAVVRVRV AIKSDMVLTL AIDYLNLVPG TMVVELDHRR RLLYVHVFDV
     SSERRVRAFY RQVAYTEKMF IKAFERDSEW HPSPYHGIDD EERA
//