ID   H0QY40_9ACTN            Unreviewed;       514 AA.
AC   H0QY40;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   RecName: Full=methylmalonate-semialdehyde dehydrogenase (CoA acylating) {ECO:0000256|ARBA:ARBA00013048};
DE            EC=1.2.1.27 {ECO:0000256|ARBA:ARBA00013048};
GN   Name=mmsA {ECO:0000313|EMBL:GAB17741.1};
GN   ORFNames=GOEFS_038_00080 {ECO:0000313|EMBL:GAB17741.1};
OS   Gordonia effusa NBRC 100432.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC   Gordonia.
OX   NCBI_TaxID=1077974 {ECO:0000313|EMBL:GAB17741.1, ECO:0000313|Proteomes:UP000035034};
RN   [1] {ECO:0000313|EMBL:GAB17741.1, ECO:0000313|Proteomes:UP000035034}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 100432 {ECO:0000313|EMBL:GAB17741.1,
RC   ECO:0000313|Proteomes:UP000035034};
RA   Yoshida I., Takarada H., Hosoyama A., Tsuchikane K., Katsumata H.,
RA   Yamazaki S., Fujita N.;
RT   "Whole genome shotgun sequence of Gordonia effusa NBRC 100432.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAB17741.1}.
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DR   EMBL; BAEH01000038; GAB17741.1; -; Genomic_DNA.
DR   RefSeq; WP_007317078.1; NZ_BAEH01000038.1.
DR   AlphaFoldDB; H0QY40; -.
DR   STRING; 1077974.GOEFS_038_00080; -.
DR   eggNOG; COG1012; Bacteria.
DR   OrthoDB; 6882680at2; -.
DR   Proteomes; UP000035034; Unassembled WGS sequence.
DR   GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:InterPro.
DR   CDD; cd07085; ALDH_F6_MMSDH; 1.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016160; Ald_DH_CS_CYS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   InterPro; IPR010061; MeMal-semiAld_DH.
DR   NCBIfam; TIGR01722; MMSDH; 1.
DR   PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR43866:SF4; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035034}.
FT   DOMAIN          25..494
FT                   /note="Aldehyde dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF00171"
SQ   SEQUENCE   514 AA;  54780 MW;  4071640547DA393C CRC64;
     MILAVTTAAP RIPHFLDGRR VDAPADSRTA DVFNPSTGQV QAVVPLASAA EVDAAVASAQ
     VAQREWAAWN PQRRARVLMK FVQLVADNSD ELAEKLSLEH GKTFEDAKGD IQRGIDVIEF
     AVGIPHLIKG EFTEGAGAGI DVHSIRQPLG VVAGITPFNF PAMIPLWKIG PALACGNAFI
     LKPSERDPSV PVRLAELFVE AGLPAGVLQV VHGDKESVDA LLDNDDVHAI GFVGSSDIAQ
     YIYENAARNG KRAQCFGGAK NHMIIMPDAD LDQAVDALIG AGYGSAGERC MAISVAVPVG
     EETANRLRAK LIDKVEGLRV GHSLDPKADY GPLVTAAALE RVKGYIGKGV DEGAELVIDG
     RDRGSNDLTF GDASLEKGFF IGPTLFDHVA KEMTIYTDEI FGPVLSIVRA GDYEEALALA
     TDHQYGNGVA IFTADGDTAR DFTSRVQVGM VGVNVPIPVP VAYHTFGGWK RSGFGDLNQH
     GPAAVQFYTK VKTITTRWPR QGDQPGASFI MPTH
//