ID   H0QZN0_9ACTN            Unreviewed;       187 AA.
AC   H0QZN0;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 41.
DE   SubName: Full=HIT family protein {ECO:0000313|EMBL:GAB18281.1};
GN   ORFNames=GOEFS_050_00590 {ECO:0000313|EMBL:GAB18281.1};
OS   Gordonia effusa NBRC 100432.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Gordoniaceae;
OC   Gordonia.
OX   NCBI_TaxID=1077974 {ECO:0000313|EMBL:GAB18281.1, ECO:0000313|Proteomes:UP000035034};
RN   [1] {ECO:0000313|EMBL:GAB18281.1, ECO:0000313|Proteomes:UP000035034}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 100432 {ECO:0000313|EMBL:GAB18281.1,
RC   ECO:0000313|Proteomes:UP000035034};
RA   Yoshida I., Takarada H., Hosoyama A., Tsuchikane K., Katsumata H.,
RA   Yamazaki S., Fujita N.;
RT   "Whole genome shotgun sequence of Gordonia effusa NBRC 100432.";
RL   Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAB18281.1}.
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DR   EMBL; BAEH01000050; GAB18281.1; -; Genomic_DNA.
DR   RefSeq; WP_007317618.1; NZ_BAEH01000050.1.
DR   AlphaFoldDB; H0QZN0; -.
DR   STRING; 1077974.GOEFS_050_00590; -.
DR   eggNOG; COG0537; Bacteria.
DR   OrthoDB; 9784774at2; -.
DR   Proteomes; UP000035034; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   CDD; cd01275; FHIT; 1.
DR   Gene3D; 3.30.428.10; HIT-like; 1.
DR   InterPro; IPR039383; FHIT.
DR   InterPro; IPR011146; HIT-like.
DR   InterPro; IPR036265; HIT-like_sf.
DR   PANTHER; PTHR42997:SF1; AP-4-A PHOSPHORYLASE; 1.
DR   PANTHER; PTHR42997; HIT FAMILY HYDROLASE; 1.
DR   Pfam; PF01230; HIT; 1.
DR   SUPFAM; SSF54197; HIT-like; 1.
DR   PROSITE; PS51084; HIT_2; 1.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035034}.
FT   DOMAIN          48..156
FT                   /note="HIT"
FT                   /evidence="ECO:0000259|PROSITE:PS51084"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           141..145
FT                   /note="Histidine triad motif"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00464"
FT   ACT_SITE        143
FT                   /note="Tele-AMP-histidine intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-1"
FT   BINDING         73
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
FT   BINDING         145
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR639383-2"
SQ   SEQUENCE   187 AA;  20448 MW;  46AB19902CD1ACBB CRC64;
     MSDIPDAYGA LRDSGTGKPD HLQRLWSPHR LTYITSEPTP ATTTGHPFLD IPAMNDDDGL
     IVARGSSVYA VLNLYPYNPG HTMIVPYRQV ADLEALTAEE SAELMAFTQR IIAVIKQVSN
     PDAFNVGLNL GRSAGGSLSE HLHQHVVPRW AGDANFITVI GETKVMPQLL RDTRALLAQA
     WQDQTSC
//