ID H0UTE6_CAVPO Unreviewed; 1203 AA.
AC H0UTE6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Pentacotripeptide-repeat region of PRORP domain-containing protein {ECO:0000259|Pfam:PF17177};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000000178.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000000178.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000000178.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02023896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02023897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02023898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0UTE6; -.
DR STRING; 10141.ENSCPOP00000000178; -.
DR Ensembl; ENSCPOT00000000207.3; ENSCPOP00000000178.3; ENSCPOG00000000204.4.
DR VEuPathDB; HostDB:ENSCPOG00000000204; -.
DR eggNOG; KOG4318; Eukaryota.
DR GeneTree; ENSGT00390000016775; -.
DR HOGENOM; CLU_006166_0_0_1; -.
DR InParanoid; H0UTE6; -.
DR OMA; XAINILK; -.
DR TreeFam; TF323626; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000000204; Expressed in heart left ventricle and 12 other cell types or tissues.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR033490; LRP130.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR033443; PPR_long.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR NCBIfam; TIGR00756; PPR; 2.
DR PANTHER; PTHR46669; LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL; 1.
DR PANTHER; PTHR46669:SF1; LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF01535; PPR; 3.
DR Pfam; PF17177; PPR_long; 1.
DR PROSITE; PS51375; PPR; 5.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT REPEAT 9..43
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT DOMAIN 32..143
FT /note="Pentacotripeptide-repeat region of PRORP"
FT /evidence="ECO:0000259|Pfam:PF17177"
FT REPEAT 44..78
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 79..113
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 558..592
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 765..799
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
SQ SEQUENCE 1203 AA; 136785 MW; A0521F6981031DC3 CRC64;
MEEANIQPNR VTYQRLIAAY CNIGDIEGAS KILEFMKTKD LPVTEAVFSA LVTGHAKAGD
MENAENILIV MRQAGIEPGP DTYLALLNAY AEKGDIDHVK EILEKVQKSD LYLMDRDLLQ
LVFSFSKAGY PQYVSEILEK FTYERRYIPD AINLILLLVT EKLEDTALQV LLACPITRED
NQSDFGSFFL RHCVTMNTPA EKLTDYCKKL KEAHMHTSPL RFTLHCALQA NKTGLAISLM
KALKEDFPVR IHYFWPLLVG HQKEKNVQGI IDVLKGMREV GIEPDPETYL SYVFPSFDSV
TSARALLQEN ECLPTSNSFD VAEVKSEAMK GNLDFVLSLL ESNTLPLSFN SLRGSLVLGF
KRSMNINLWS KITELLYKDG RYCQELSGPT EAVGYFLYNL IDSMSDSEVQ AKEERLRQYF
HQLKEMNIKI SENIFRGIRN LLDSYHVPEL IKDVYALMNK EIDFRKTSRI TSSDLESTLE
KLKNNNQPIE DVLKQLILIL CSEENMQKAL ALKTKYESDM VVGGYAALIS LCCRHNNAED
ALNLKQEFDR LDSSAVLDTN KYVGLVRVLG KHGKLQDAIN ILKEMKEKDV LIKDATVLSF
FHILNGAALR GESETVKQLH EAIVTLGLAK PSTNISFPLV TVHLEKGDLP AALEASIDCY
KKYKILPRMH DVLCKLIEKG ETDLIQKAMD FVSQEQGEMT MLYDIFFAFL QTGNYKEAKK
IIETPGIRAR PAKLQWFCER CITNNQIETL EKLVELTQKL FECDRDQLYY SLLKLYKKNG
DWQSADTVWN KMQEENIIPR EKTLRLLAEI LKDSNQEVPF DVPELWYEDS TDTPVSSLAP
VNPLIEKELL KACRQRKNRD AYNIFLKAQE QNIIFNSDTY RTLIKLLLLK DSFTEAMQVK
NAAETHIKGF TLNDAANSIL IIAQVRRDYL KEALATLKTV LDLDQVPSRL SVTRLTQAFA
SKGDVQSIEA VQKMVSGRDS IVLSNMIFIN NIALAQIKNN NIDVAIENIE NMLTSVDKTI
EPQYFGLSYL FRKVMEEQME TAVEKLSIMA ERLANQFAVY KPVTDLFLQL VNSGKVDDAR
ALLQRCGAIA EQTPILLVFF VRSAQIKGKA PVLKSLLDLI PELRDTEEAY TSTMKSYVLD
NDLPSAKMLY EHLTAKNLKL NNLFLKRYAL LLKNAGEPVP FTEPPESFEF YAKQLKESKE
TPS
//
