ID H0UTP3_CAVPO Unreviewed; 635 AA.
AC H0UTP3;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN Name=GUCY1A2 {ECO:0000313|Ensembl:ENSCPOP00000000292.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000000292.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000000292.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000000292.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02024503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02024504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02024505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02024506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02024507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02024508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02024509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02024510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0UTP3; -.
DR STRING; 10141.ENSCPOP00000000292; -.
DR Ensembl; ENSCPOT00000000338.3; ENSCPOP00000000292.3; ENSCPOG00000000335.4.
DR VEuPathDB; HostDB:ENSCPOG00000000335; -.
DR eggNOG; KOG4171; Eukaryota.
DR GeneTree; ENSGT00940000157765; -.
DR HOGENOM; CLU_011614_5_0_1; -.
DR InParanoid; H0UTP3; -.
DR OMA; SLMLHYF; -.
DR TreeFam; TF351403; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000000335; Expressed in heart left ventricle and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0007263; P:nitric oxide mediated signal transduction; IEA:Ensembl.
DR GO; GO:0010750; P:positive regulation of nitric oxide mediated signal transduction; IEA:Ensembl.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655:SF7; GUANYLATE CYCLASE SOLUBLE SUBUNIT ALPHA-2; 1.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447}.
FT DOMAIN 424..551
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 365..396
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 635 AA; 71775 MW; 91FF124E0C99D71B CRC64;
TAPSPQTIQQ TLKRTLQYYE HQVIGYRDAE KNFHNISNRC SYADYSNKEE IEDVSGILQC
TANILGLKFE EIQERFGEEF FKICFDENER VLRAVGGTLQ DFFNGFDALL EHIRTSFGKQ
ATLESPSFLC KELPEGSLML HYYHPHHVVG FAMLGMIKAA GKKIYHLDVE VEQVAHEKLC
SDGSNPGNCN CLTFLIKECE NTNVTKNLPQ GTSQVPADLR ISISTFCRAF PFHLMFDPNM
SVLQLGEGLR KQLRCDTHKV LKFEDCFEIV SPKVDATFER VLLRLSTPFV IRTKPEASST
ENKDKVMEIK GQMIHVPESS SILFLGSPCV DKLDELMGRG LHLSDIPIHD ATRDVILVGE
QAKAQDGLKK RMDKLKATLE RTHQALEEEK KKTVDLLYSI FPGDVAQQLW QGQQVQARKF
DDVTMLFSDI VGFTAICAQC TPMQVISMLN ELYTRFDHQC GFLDIYKVET IGDAYCVAAG
LHRKSLCHAK PIALMALKMM ELSEEVLTPD GRPIQMRIGI HSGSVLAGVV GVRMPRYCLF
GNNVTLASKF ESGSHPRRIN VSPTTYQLLK REESFTFIPR SREELPDNFP KEIPGICYFL
EVRTGPKQPK PSLSSSRIKK VSYNIGTMFL RETSL
//
