ID H0UUK4_CAVPO Unreviewed; 2820 AA.
AC H0UUK4;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Fibrillin 2 {ECO:0000313|Ensembl:ENSCPOP00000000646.3};
GN Name=FBN2 {ECO:0000313|Ensembl:ENSCPOP00000000646.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000000646.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000000646.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000000646.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- SIMILARITY: Belongs to the fibrillin family.
CC {ECO:0000256|ARBA:ARBA00008972}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AAKN02010153; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02010154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02010155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02010156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000000646; -.
DR Ensembl; ENSCPOT00000000731.3; ENSCPOP00000000646.3; ENSCPOG00000000726.4.
DR VEuPathDB; HostDB:ENSCPOG00000000726; -.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00950000183158; -.
DR HOGENOM; CLU_000233_0_0_1; -.
DR InParanoid; H0UUK4; -.
DR OMA; HQCVACP; -.
DR TreeFam; TF316849; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000000726; Expressed in testis and 4 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:Ensembl.
DR GO; GO:0001527; C:microfibril; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0060346; P:bone trabecula formation; IEA:Ensembl.
DR GO; GO:0043010; P:camera-type eye development; IEA:Ensembl.
DR GO; GO:0048048; P:embryonic eye morphogenesis; IEA:Ensembl.
DR GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
DR GO; GO:0030501; P:positive regulation of bone mineralization; IEA:Ensembl.
DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
DR GO; GO:0035583; P:sequestering of TGFbeta in extracellular matrix; IEA:Ensembl.
DR CDD; cd11304; Cadherin_repeat; 1.
DR CDD; cd00054; EGF_CA; 26.
DR Gene3D; 2.10.25.10; Laminin; 44.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 9.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR049388; FBN_EGF_N.
DR InterPro; IPR040872; Fibrillin_U_N.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24039:SF49; FIBRILLIN 2; 1.
DR PANTHER; PTHR24039; FIBRILLIN-RELATED; 1.
DR Pfam; PF12662; cEGF; 3.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 35.
DR Pfam; PF21364; FBN_EGF_st1; 1.
DR Pfam; PF18193; Fibrillin_U_N; 1.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF00683; TB; 9.
DR PIRSF; PIRSF036312; Fibrillin; 2.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 44.
DR SMART; SM00179; EGF_CA; 42.
DR SUPFAM; SSF57196; EGF/Laminin; 10.
DR SUPFAM; SSF57184; Growth factor receptor domain; 11.
DR SUPFAM; SSF57581; TB module/8-cys domain; 9.
DR PROSITE; PS00010; ASX_HYDROXYL; 40.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 27.
DR PROSITE; PS50026; EGF_3; 40.
DR PROSITE; PS01187; EGF_CA; 17.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS51364; TB; 9.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..2820
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012587610"
FT DOMAIN 168..200
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 206..249
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 268..309
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 310..351
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 356..398
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 438..478
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 479..518
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 519..560
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 561..601
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 602..642
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 648..689
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 708..749
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 750..791
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 792..831
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 836..875
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 895..936
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 941..992
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1013..1054
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1055..1097
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1098..1139
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1140..1181
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1223..1264
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1265..1302
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1307..1347
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1348..1388
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1389..1430
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1461..1501
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1506..1562
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1579..1620
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1621..1662
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1667..1720
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 1737..1778
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1779..1820
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1821..1858
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1863..1898
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1902..1944
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1945..1984
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1985..2026
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2031..2084
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2100..2141
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2142..2181
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2223..2266
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2292..2345
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 2357..2394
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2399..2439
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2440..2476
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2479..2521
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2562..2598
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2603..2642
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 29..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..47
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 172..182
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 190..199
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 483..493
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 796..806
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1867..1877
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2820 AA; 305339 MW; 8CF211396EEC9649 CRC64;
MGRRRRPCLQ PYFVWLGCVA LWVQGTAGQP QPQQSKPPRP QPPLPQVRPA AAGSEGREGA
AAASRVRRRG QQDVLRGPNV CGSRFHSYCC PGWKTLPGGN QCIVPICRNS CGDGFCSRPN
MCTCSSGQIS PTCGAKSIQQ CSVRCMNGGT CADDHCQCQK GYIGTFCGQP VCENGCQNGG
RCIGPNRCAC VYGFTGPQCE RDYRTGPCFT QVNNQMCQGQ LTGIVCTKTL CCATIGRAWG
HPCEMCPAQP QPCRRGFIPN IRTGACQDVD ECQAIPGICQ GGNCINTVGS FECRCPAGHK
QSETTQKCED IDECSIIPGI CETGECSNTV GSYFCVCPRG YVTSTDGARC IDQRTGTCFS
GLVNGRCAQE LPGRMTRTQC CCEPGRCWGI GSIPEACPEY CQLCTVSALF TESTLENSGV
GAGGQGPLIT GLTILNQTID ICKHHANLCL NGRCIPTVSS YRCECNMGYK QDANGDCIDV
DECTSNPCTN GDCVNTPGSY YCKCHAGFQR TPTKQACIDI DECIQNGVLC KNGRCVNTDG
SFQCICNAGF ELTTDGKNCV DHDECTTTNM CLNGMCINED GSFKCICKPG FVLAPNGRYC
TDVDECQTPG ICMNGHCINN EGSFRCDCPP GLAVGVDGRV CVDTHMRSTC YGGIKKGACV
RPFPGAVTKS ECCCANPDYG FGEPCQPCPL NSMAFCSSGV GITVDGRDIN ECALDPDICA
NGICENLRGS YRCNCNSGYE PDASGRNCID IDECLVNRLL CDNGLCRNTP GSYSCTCPPG
YVFRTETETC EDINECESNP CVNGACRNNL GSFNCECSPG SKLSSTGLIC IDSLKGTCWL
HIQDNRCEVN INGATLKSEC CATLGAAWGS PCERCELDTA CPRGLARIKG VTCEDVNECE
VFPGVCPNGR CVNSKGSFHC ECPEGLTLDG TGRVCLDIRM EQCFLKWDED ECVHPVPGKF
RMDACCCAVG AAWGTECEEC PKPGTKEYET LCPRGPGFAN RGDVLTGRPF YKDINECKAF
PGMCTYGKCR NTIGSFKCRC NSGFALDMEE RNCTDIDECR ISPDLCGSGI CVNTPGSFEC
ECFEGYESGF MMMKNCMDID ECERNPLLCR GGTCVNTEGS FQCDCPLGHE LSPSREDCVD
INECSLSDNL CRNGKCVNMI GTYQCSCNPG YQATPDRQGC TDIDECMIMN GGCDTQCTNA
EGSYECSCSE GYALLPDGRS CADIDECENN PEICDGGQCT NIPGEYRCLC YDGFMASMDM
KTCLDVNECD LNSNICMFGE CENTKGSFIC HCQLGYSVKK GTTGCTDVDE CEIGAHNCDM
HASCLNVPGS FKCSCREGWV GNGIKCIDLD ECSNGTHQCS INAQCVNTPG SYRCACAEGF
TGDGFTCSDV DECAENINLC ENGQCLNVPG AYRCECEMGF TPAPDSRSCQ DIDECSYQNI
CVFGTCNKFA WKCSHCICDD DIDECADPIN CVNGLCVNTP GRYECNCPPD FQLNPTGVGC
VDNRVGNCYL KFGPRGDGSL SCNTEIGVGV SRSSCCCSLG KAWGNPCETC PPVNSTEYYT
LCPGGEGFRP NPITIILEDI DECQELPGLC QGGNCINTFG SFQCECPQGY YLSEETRICE
DIDECFAHPG VCGPGTCYNT LGNYTCICPP EYMQVNGGHN CMDMRKSFCY RSYNGTTCEN
ELPFNVTKRM CCCTYNVGKA WNKPCEPCPT PGTADFKTIC GNIPGFTFDI HTGKAVDIDE
CKEIPGICAN GVCINQIGSF RCECPTGFSY NDLLLVCEDI DECSNGDSLC QRNADCINSP
GSYRCECAAG FKLSPNGACV DRNECLEIPN VCSHGLCVDL QGSYQCICHN GFKASQDQTM
CMDVDECERH PCGNGTCKNT VGSYNCLCYP GFELTHNNDC LDVDECSSFF GQVCRNGRCF
NEIGSFKCLC NEGYELTPDG KNCIDTNECV ALPGSCSPGT CQNLEGSFRC ICPPGYEVKS
ESCIDINECD EDPNICLFGS CTNTPGGFQC ICPPGFVLSD NGRRCFDTRQ SFCFTNFENG
KCSVPKAFNT TKAKCCCSKM PGEGWGDPCE LCPKDDEVAF QDLCPYGHGT VPSLHDTRED
VNECLESPGI CSNGQCINTD GSFRCECPMG YNLDYTGVRC VDTDECSIGN PCGNGTCTNV
IGSFECNCNE GFEPGPMMNC EDINECAQNP LLCAFRCMNT FGSYECTCPM GYALREDQKM
CKDLDECAEG LHDCESRGMM CKNLIGTFMC ICPPGMARRP DGEGCVGKLS GGFCLGTTLL
HTASSPHYNR QGLCFAEVLQ TMCQMASSSR NLVTKSECCC DGGRGWGHQC ELCPLPGTAQ
YKKICPHGPG YTTDGRDIDE CKVMPNLCTS GQCINTMGSF RCFCKVGYTT DISGTSCVDL
DECSQSPKPC NFICKNTEGS YQCSCPRGYV LQEDGKTCKD LDECQTKQHN CQFLCVNTLG
GFTCKCPPGF TQHHTACIDN NECGSQPSLC GAKGICQNTP GSFSCECQRG FSLDATGLNC
EDVDECDGNH RCQHGCQNIL GGYRCGCPQG YIQHYQWNQC VDENECSNPG ACGSASCYNT
LGSYKCACPS GFSFDQFSSA CHDVNECSSS KNPCNYGCSN TEGGYLCGCP PGYYRVGQGH
CVSGMGFNKG QYLSLDTEVD EENALSPEAC YECKINGYSK KESRQKRSVD DPEPAAVEQV
SLESVDMDSP VNMKFNLSGL GSEEHILELM PAIEPLNNHV RYVISQGNDD GVFRIHQRNG
LSYLHTAKRK PLPGTYTLEI TSVPLYRKKE LRKLEESKED DYLVGELGEA LRMRLQIQLY
//
