ID H0UUM9_CAVPO Unreviewed; 645 AA.
AC H0UUM9;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=CD180 molecule {ECO:0000313|Ensembl:ENSCPOP00000000676.3};
GN Name=CD180 {ECO:0000313|Ensembl:ENSCPOP00000000676.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000000676.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000000676.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000000676.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAKN02053270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02053271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0UUM9; -.
DR STRING; 10141.ENSCPOP00000000676; -.
DR Ensembl; ENSCPOT00000000762.3; ENSCPOP00000000676.3; ENSCPOG00000000757.4.
DR VEuPathDB; HostDB:ENSCPOG00000000757; -.
DR eggNOG; KOG4641; Eukaryota.
DR GeneTree; ENSGT00940000161183; -.
DR HOGENOM; CLU_006000_5_1_1; -.
DR InParanoid; H0UUM9; -.
DR OMA; MCTEKEA; -.
DR TreeFam; TF351113; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000000757; Expressed in heart left ventricle and 10 other cell types or tissues.
DR GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0002322; P:B cell proliferation involved in immune response; IEA:Ensembl.
DR GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0031666; P:positive regulation of lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR041281; LRR_11.
DR InterPro; IPR026906; LRR_5.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24373:SF356; CD180 ANTIGEN; 1.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR Pfam; PF18831; LRR_11; 1.
DR Pfam; PF13306; LRR_5; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..645
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5011977248"
FT TRANSMEM 611..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 561..610
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
SQ SEQUENCE 645 AA; 72082 MW; B12D3D156808CFDF CRC64;
MAPDVSCIFL AVLLSASCEV ITSADQMCIE IPDTLPNTTE FLEFGFYFLP TIQDITFSRL
INLTFLDLTR CQINWIHENA FQSHPQLSTL VLTGNPLIFV AETALNGPES LKHLFLIQTG
ISSLEFIPAY NLKNLESLHL GSNYISSVKF PKDFPTGNLK VLDFQNNAIH YLSREDMDSL
RPATYLNLNF NGNDIKGIEP GAFKSMAFQS LNFGGTVDLS VIFGGLHNST IQSLWLGTYE
DIESHHLNSA MFTELCEMSV ESMNLQLHYF SNLSSTTFRC FTHLQELDLT ACHLKELPSG
IKGMTSLKKL ILSVNKFTQL CQINAASFPS LTHLYIKGNT NKLELGAGCL EKLENLQKLD
LSHNGIDASD CCNLQLKTLP QLQSLNLSYN QPLGLQNEAF KVCPRLELLD LAFTRLHVIA
EQSPFQNLDL LQVLNLSHCL LDASNEHLLA GLPNLRHLNL QGNHFKDGNI PKINLFQMVG
SLEILVLSSC DLSSIDPEAF HSLGNMTYID LSHNNLTSSS INALNQFKGT YLNLAANSIR
IIPPQVLPIL SQQKVINLSH NPLDCTCSNI HFLTWYKENV QKLKDFVEIR CATPPSLQGV
QLSDVTLSCG ITAVGIFFLI IFLFLSAALL IYAVKFFLRW KYQHI
//
