ID H0UUR2_CAVPO Unreviewed; 416 AA.
AC H0UUR2;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Carbohydrate sulfotransferase {ECO:0000256|RuleBase:RU364020};
DE EC=2.8.2.- {ECO:0000256|RuleBase:RU364020};
GN Name=CHST8 {ECO:0000313|Ensembl:ENSCPOP00000000710.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000000710.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000000710.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000000710.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323, ECO:0000256|RuleBase:RU364020}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004323,
CC ECO:0000256|RuleBase:RU364020}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 2 family.
CC {ECO:0000256|ARBA:ARBA00006339, ECO:0000256|RuleBase:RU364020}.
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DR EMBL; AAKN02042158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0UUR2; -.
DR STRING; 10141.ENSCPOP00000000710; -.
DR Ensembl; ENSCPOT00000000798.3; ENSCPOP00000000710.3; ENSCPOG00000000793.4.
DR VEuPathDB; HostDB:ENSCPOG00000000793; -.
DR eggNOG; KOG4651; Eukaryota.
DR GeneTree; ENSGT00940000159100; -.
DR HOGENOM; CLU_043398_5_1_1; -.
DR InParanoid; H0UUR2; -.
DR OMA; WAPDGHW; -.
DR TreeFam; TF325581; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000000793; Expressed in ovary and 11 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001537; F:N-acetylgalactosamine 4-O-sulfotransferase activity; IEA:Ensembl.
DR GO; GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro.
DR GO; GO:0042446; P:hormone biosynthetic process; IEA:Ensembl.
DR GO; GO:0030166; P:proteoglycan biosynthetic process; IEA:Ensembl.
DR GO; GO:0006790; P:sulfur compound metabolic process; IEA:Ensembl.
DR InterPro; IPR018011; Carb_sulfotrans_8-10.
DR InterPro; IPR005331; Sulfotransferase.
DR PANTHER; PTHR12137; CARBOHYDRATE SULFOTRANSFERASE; 1.
DR PANTHER; PTHR12137:SF7; CARBOHYDRATE SULFOTRANSFERASE 8; 1.
DR Pfam; PF03567; Sulfotransfer_2; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|RuleBase:RU364020};
KW Glycoprotein {ECO:0000256|RuleBase:RU364020};
KW Golgi apparatus {ECO:0000256|RuleBase:RU364020};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Signal-anchor {ECO:0000256|RuleBase:RU364020};
KW Transferase {ECO:0000256|RuleBase:RU364020};
KW Transmembrane {ECO:0000256|RuleBase:RU364020}.
FT REGION 50..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 416 AA; 48295 MW; 1DDDF4BDCB4534DD CRC64;
MTLRPGTMRL ACMFSSILLF GAAGLLLFIS LQDPTELAPQ HMPGIKFNIR PQKPHKDGDV
KVSTERVTQD LSSRTPRDLK LQVPDQPQLY PKTGARLRPR QRRRRLLIKK MPAAVAIVAN
SSSETLAPPG HQAPDSHWVK LHRSQQERKR VMREACAKYR ASSSRRPVTP RHVSRIFVED
RHRVLYCEVP KVGCSNWKRV LMVLAGLASS TADIQHNTVH YGSALKRLDT FNRQGILHRL
GTYTKMLFVR EPFERLVSAF RDKFEHPNSY YHPVFGKAIL ARYRANASRE ALRTGSGVRF
PEFIQYLLDV HRPVGMDIHW DHVSRLCSPC LIDYDFVGKF ESMEDDANFF LSLIRAPHNL
TFPRFKDRHS QEARTTSRIT HQYFAQLSAL QRQRTYDFYY MDYLMFNYSK PFADLY
//
