ID H0UV55_CAVPO Unreviewed; 819 AA.
AC H0UV55;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Protein kinase C-binding protein NELL2 {ECO:0000256|ARBA:ARBA00040506};
DE AltName: Full=NEL-like protein 2 {ECO:0000256|ARBA:ARBA00042609};
GN Name=NELL2 {ECO:0000313|Ensembl:ENSCPOP00000000875.3};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000000875.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSCPOP00000000875.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000000875.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AAKN02015166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02015167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02015168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02015169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02015170; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02015171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02015172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02015173; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAKN02015174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; H0UV55; -.
DR STRING; 10141.ENSCPOP00000000875; -.
DR Ensembl; ENSCPOT00000000982.3; ENSCPOP00000000875.3; ENSCPOG00000000976.4.
DR VEuPathDB; HostDB:ENSCPOG00000000976; -.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00810000125439; -.
DR HOGENOM; CLU_006887_0_0_1; -.
DR InParanoid; H0UV55; -.
DR OMA; TCGQFLE; -.
DR TreeFam; TF323325; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000000976; Expressed in frontal cortex and 11 other cell types or tissues.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0071679; P:commissural neuron axon guidance; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 3.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 6.20.200.20; -; 2.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24042; NEL HOMOLOG; 1.
DR PANTHER; PTHR24042:SF0; PROTEIN KINASE C-BINDING PROTEIN NELL2; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF00093; VWC; 2.
DR SMART; SM00181; EGF; 6.
DR SMART; SM00179; EGF_CA; 5.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 3.
DR SMART; SM00215; VWC_out; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57603; FnI-like domain; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..819
FT /note="Protein kinase C-binding protein NELL2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012858907"
FT DOMAIN 275..334
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 400..442
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 443..484
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 485..525
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 526..556
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 558..604
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 605..640
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 641..696
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 701..759
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT COILED 244..271
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 528..538
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 546..555
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 819 AA; 91707 MW; F2FC5876662AAD1E CRC64;
IRTMESRVLL KTFCLIFCLG AVWGLGVDPS LQIDVLTELE LGEFTAGVRQ VPGLHNGTKA
FLFQDTPRSI KASTDTAEKF FQKLKNKHEF TVLVTLKQMH LNSGVILSIH HLDHRYLELE
SSGHRNEIRL HYRSGGHRPH TEVFPYILAD DKWHRLSLAI SASHLILHID CNKIYERVVE
KPSTDLPLGT TFWLGQRNNA HGYFKGVMQD VQLLVMPQGF IAQCPDLNRT CPTCNDFHGL
VQKIMELQDI LAKTSAKLSR AEQRMNRLDQ CYCERTCTMK GTTYREFESW TDGCKNCTCL
NGTIQCETLI CPIPDCPLKS APAYVDGKCC KECRSICQFQ GRTYFEGERN TVYSSSGVCV
LYECKDQTMK LVESSGCPDL DCPESHQITL SHSCCKVCKG YDFCSERHNC MENSVCRNLN
DRAVCSCRDG FRALREDNAY CEDIDECAEG RHYCRENTMC VNTPGSFMCI CKTGYIRIDD
YSCTEHDECA TNQHSCDENA LCFNTVGGHN CVCKPGYTGN GTTCRAFCKD GCRNGGACIA
ANLCACPQGF TGPSCETDID ECSDGFVQCD SRANCVNLPG WYHCECRDGY HDNGMFSPGG
ESCEDIDECG TGRHSCANDT ICFNLDGGYD CRCPHGKNCT GDCIHDGKVK HSGQIWVLEN
DRCSVCSCQN GFVMCRRMVC DCENPTVDLF CCPECDPRLS SQCLHQNGET LYNSGDTWVQ
NCQQCRCLQG EVDCWPLPCP DVECEFSVLP ENECCPRCVS DPCQADTIRN DITKTCMDEM
NVVRFTGSSW IKHGTECTLC QCKNGQICCS VDPQCLQEL
//
