ID H0UVG1_CAVPO Unreviewed; 258 AA.
AC H0UVG1; A0A1R3UDE6;
DT 22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Kallikrein H {ECO:0000313|EMBL:SFW93276.1};
DE SubName: Full=Kallikrein related peptidase 8 {ECO:0000313|Ensembl:ENSCPOP00000000997.3};
GN Name=KLK8 {ECO:0000313|Ensembl:ENSCPOP00000000997.3};
GN Synonyms=KLNH {ECO:0000313|EMBL:SFW93276.1};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000000997.3, ECO:0000313|Proteomes:UP000005447};
RN [1] {ECO:0000313|Proteomes:UP000005447}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|EMBL:SFW93276.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28224083; DOI=10.1016/j.ymgmr.2017.01.009;
RA Premzl M.;
RT "Comparative genomic analysis of eutherian kallikrein genes.";
RL Mol. Genet. Metab. Rep. 10:96-99(2017).
RN [3] {ECO:0000313|EMBL:SFW93276.1}
RP NUCLEOTIDE SEQUENCE.
RX DOI=10.1016/j.genrep.2019.100414;
RA Premzl M.;
RT "Eutherian third-party data gene collections.";
RL Gene Rep 16:100414-100414(2019).
RN [4] {ECO:0000313|Ensembl:ENSCPOP00000000997.3}
RP IDENTIFICATION.
RC STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000000997.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAKN02046384; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; LT631629; SFW93276.1; -; Genomic_DNA.
DR STRING; 10141.ENSCPOP00000000997; -.
DR Ensembl; ENSCPOT00000001113.3; ENSCPOP00000000997.3; ENSCPOG00000001102.4.
DR VEuPathDB; HostDB:ENSCPOG00000001102; -.
DR eggNOG; KOG3627; Eukaryota.
DR GeneTree; ENSGT01020000230389; -.
DR HOGENOM; CLU_004497_1_0_1; -.
DR OMA; GMTCYSG; -.
DR OrthoDB; 4629979at2759; -.
DR TreeFam; TF331065; -.
DR Proteomes; UP000005447; Unassembled WGS sequence.
DR Bgee; ENSCPOG00000001102; Expressed in zone of skin and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0097180; C:serine protease inhibitor complex; IEA:Ensembl.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:Ensembl.
DR GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:0007613; P:memory; IEA:Ensembl.
DR GO; GO:0048812; P:neuron projection morphogenesis; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0050807; P:regulation of synapse organization; IEA:Ensembl.
DR GO; GO:0009611; P:response to wounding; IEA:Ensembl.
DR GO; GO:0050808; P:synapse organization; IEA:Ensembl.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24271:SF62; KALLIKREIN-8; 1.
DR PANTHER; PTHR24271; KALLIKREIN-RELATED; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..258
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015092170"
FT DOMAIN 33..255
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
SQ SEQUENCE 258 AA; 28069 MW; D02D0106FC9AB213 CRC64;
MGRPLPCAGL MWAVLLLLLA SWAGRTEAQE SKVLQGHECE AHSQPWQTAL FQGQRLLCGG
VLVDPMWVLS AAHCKKIKYT VRLGDHSLLS KPDQEISVAR SIQHPCFNHS NNEDHSHDLM
LIRLSKQAAL GPKVKPINLA KQCARVGQKC TISGWGTVTS PRENFPDTLN CAEVEIFSQK
KCEEAYPGKV NDGMICAGNS NGADTCQGDS GGPLVCGGVL QGITSWGSDP CGRPKKPGVY
TNICRYLNWI KKTMGNRS
//
