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Database: UniProt
Entry: H0UW89_CAVPO
LinkDB: H0UW89_CAVPO
Original site: H0UW89_CAVPO 
ID   H0UW89_CAVPO            Unreviewed;       655 AA.
AC   H0UW89;
DT   22-FEB-2012, integrated into UniProtKB/TrEMBL.
DT   22-FEB-2012, sequence version 1.
DT   24-JAN-2024, entry version 70.
DE   RecName: Full=SPARC-like protein 1 {ECO:0000256|PIRNR:PIRNR002574};
GN   Name=SPARCL1 {ECO:0000313|Ensembl:ENSCPOP00000001315.2};
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000001315.2, ECO:0000313|Proteomes:UP000005447};
RN   [1] {ECO:0000313|Proteomes:UP000005447}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2N {ECO:0000313|Proteomes:UP000005447};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSCPOP00000001315.2}
RP   IDENTIFICATION.
RC   STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000001315.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|PIRNR:PIRNR002574}.
CC   -!- SIMILARITY: Belongs to the SPARC family.
CC       {ECO:0000256|ARBA:ARBA00006404, ECO:0000256|PIRNR:PIRNR002574}.
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DR   EMBL; AAKN02033404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003469421.1; XM_003469373.3.
DR   AlphaFoldDB; H0UW89; -.
DR   STRING; 10141.ENSCPOP00000001315; -.
DR   Ensembl; ENSCPOT00000001474.3; ENSCPOP00000001315.2; ENSCPOG00000001455.4.
DR   GeneID; 100734715; -.
DR   KEGG; cpoc:100734715; -.
DR   CTD; 8404; -.
DR   VEuPathDB; HostDB:ENSCPOG00000001455; -.
DR   eggNOG; KOG4004; Eukaryota.
DR   GeneTree; ENSGT00510000046787; -.
DR   HOGENOM; CLU_026297_0_1_1; -.
DR   InParanoid; H0UW89; -.
DR   OMA; CKRGHVC; -.
DR   OrthoDB; 4695638at2759; -.
DR   TreeFam; TF319356; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000001455; Expressed in hypothalamus and 13 other cell types or tissues.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProtKB-UniRule.
DR   GO; GO:0099560; P:synaptic membrane adhesion; IEA:Ensembl.
DR   CDD; cd16236; EFh_SPARC_SPARCL1; 1.
DR   Gene3D; 3.30.60.30; -; 1.
DR   Gene3D; 1.10.238.10; EF-hand; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR003645; Fol_N.
DR   InterPro; IPR015369; Follistatin/Osteonectin_EGF.
DR   InterPro; IPR002350; Kazal_dom.
DR   InterPro; IPR036058; Kazal_dom_sf.
DR   InterPro; IPR001999; Osteonectin_CS.
DR   InterPro; IPR016359; SPARC-like_p1.
DR   InterPro; IPR019577; SPARC/Testican_Ca-bd-dom.
DR   PANTHER; PTHR13866; SPARC OSTEONECTIN; 1.
DR   PANTHER; PTHR13866:SF16; SPARC-LIKE PROTEIN 1; 1.
DR   Pfam; PF09289; FOLN; 1.
DR   Pfam; PF00050; Kazal_1; 1.
DR   Pfam; PF10591; SPARC_Ca_bdg; 1.
DR   PIRSF; PIRSF002574; SPARC-like_p1; 1.
DR   SMART; SM00274; FOLN; 1.
DR   SMART; SM00280; KAZAL; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS51465; KAZAL_2; 1.
DR   PROSITE; PS00612; OSTEONECTIN_1; 1.
DR   PROSITE; PS00613; OSTEONECTIN_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRNR:PIRNR002574};
KW   Extracellular matrix {ECO:0000256|ARBA:ARBA00022530,
KW   ECO:0000256|PIRNR:PIRNR002574};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRNR:PIRNR002574};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005447};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR002574};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..655
FT                   /note="SPARC-like protein 1"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003541133"
FT   DOMAIN          446..502
FT                   /note="Kazal-like"
FT                   /evidence="ECO:0000259|PROSITE:PS51465"
FT   DOMAIN          613..648
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   REGION          30..353
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          376..418
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..106
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        108..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..138
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..180
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        181..237
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        243..258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        283..319
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..349
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        376..416
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   655 AA;  73967 MW;  3CDB4907827B844E CRC64;
     MKTVPFLLCL LGTAVAIPTN ARFLPDHSKS TAEPLVMPDN KEIPIVSADA ADNEKETTGS
     KENHPNHKAE QSSTLRSEEG THELSAEQDK TQSHELGLKE QDGDDELSVN LEYSTTEGNL
     EPQEDTGEPQ KKKLQEDTDF SASNVSSLVD SNQQENITKG EGYQEQPGND SHLQLDKNST
     QSQDLREEES QEQDANIPNG KEEEETEPGK ADTPTDNPDK EKEFPEDNSN SKQEDNEQPD
     DILEEANQPT QVSKMQEDEL EQGSQEKEED NSNVGLEEDS ASNISEHTPD TERQSQEGKM
     GLKAIGDHKD IDKKTVSEAL LLDPTDVNHM TPRNHGADTD NDDSKHSAGD DYFVPSQDFT
     EAEKAQSISY HLKYEEERDR AHKNENVDAS EPADHQEDKN AQSSSNEEEA SSEGHMRAHG
     TDSCVNFQCK RGHVCKAEPQ GTPHCVCQDP ETCPPAKPLD QACGTDNQTY ASSCHLFATK
     CRLEGTKKGH QLQLDYFGAC KSIPVCTDFE VAQFPLRMRD WLKNILMQLY EPNPKHAGYL
     NEKQRTKVKK IYLDEKRLLA GDHPIELLLR DFKKNYHMYV YPVHWQFSEL DRHPMDRVLT
     HSELAPLRAS LVPMEHCITR FFEECDPNKD KHITLKEWGH CFGIKEEDID ENLLF
//
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